Explore the words cloud of the GLYCANAL project. It provides you a very rough idea of what is the project "GLYCANAL" about.
The following table provides information about the project.
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
|Coordinator Country||Switzerland [CH]|
|Total cost||2˙499˙801 €|
|EC max contribution||2˙499˙801 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2018-09-01 to 2023-08-31|
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|1||ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE||CH (LAUSANNE)||coordinator||2˙499˙801.00|
Glycans, or oligosaccharides, are ubiquitous in biological systems. Because they decorate the surface of cells, they play a key role in virtually all cellular recognition processes and are implicated in almost every major disease. Despite their importance, the characterization of glycan primary structure lags far behind that of proteins and DNA because of their intrinsic isomeric complexity. The isomeric nature of the monosaccharide building blocks, the stereochemistry of the glycosidic bond, the possibility of multiple attachment points, and the occurrence of isomeric branched structures all make glycans difficult to analyze.
Although mass spectrometry (MS) is one of the most sensitive approaches for glycan analysis, it has difficulty to distinguish all these various types of isomerisms. Ion mobility spectrometry (IMS) combined with MS has demonstrated some ability to identify glycan anomers and regioisomers, but cannot easily distinguish isomeric disaccharides, for example.
We have recently demonstrated that cryogenic infrared spectroscopy provides unique vibrational fingerprints of glycans that distinguishes all the various types of isomerism. When combined with simultaneous measurements of mass and ion mobility, these fingerprints can be tabulated in a database and used to identify a given glycan from a mixture. However, adding a spectroscopic dimension to ion mobility and mass measurements requires additional time, which hampers it use as an analytical tool. To use spectroscopic data for real-world glycan analysis, one must multiplex the measurement process and record the vibrational spectrum of many species simultaneously.
This project involves designing and constructing an instrument that combines state-of-the-art ion mobility separation, cryogenic ion spectroscopy, and time-of-flight mass spectrometry to perform high throughput analysis of glycan primary structure. The success of this project would represent a tremendous breakthrough for glycoscience.
|year||authors and title||journal||last update|
Stephan Warnke, Ahmed Ben Faleh, Robert P. Pellegrinelli, Natalia Yalovenko, Thomas R. Rizzo
Combining ultra-high resolution ion mobility spectrometry with cryogenic IR spectroscopy for the study of biomolecular ions
published pages: 114-125, ISSN: 1359-6640, DOI: 10.1039/c8fd00180d
|Faraday Discussions 217||2020-04-24|
Stephan Warnke, Ahmed Ben Faleh, Valeriu Scutelnic, Thomas R. Rizzo
Separation and Identification of Glycan Anomers Using Ultrahigh-Resolution Ion-Mobility Spectrometry and Cryogenic Ion Spectroscopy
published pages: 2204-2211, ISSN: 1044-0305, DOI: 10.1007/s13361-019-02333-0
|Journal of The American Society for Mass Spectrometry 30/11||2020-04-24|
Robert P. Pellegrinelli, Lei Yue, Eduardo Carrascosa, Stephan Warnke, Ahmed Ben Faleh, Thomas R. Rizzo
How General Is Anomeric Retention during Collision-Induced Dissociation of Glycans?
published pages: 5948-5951, ISSN: 0002-7863, DOI: 10.1021/jacs.0c00264
|Journal of the American Chemical Society 142/13||2020-04-24|
Irina Dyukova, Eduardo Carrascosa, Robert P. Pellegrinelli, Thomas R. Rizzo
Combining Cryogenic Infrared Spectroscopy with Selective Enzymatic Cleavage for Determining Glycan Primary Structure
published pages: 1658-1662, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.9b04776
|Analytical Chemistry 92/2||2020-04-24|
Ahmed Ben Faleh, Stephan Warnke, Thomas R. Rizzo
Combining Ultrahigh-Resolution Ion-Mobility Spectrometry with Cryogenic Infrared Spectroscopy for the Analysis of Glycan Mixtures
published pages: 4876-4882, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.9b00659
|Analytical Chemistry 91/7||2020-04-24|
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