Opendata, web and dolomites

Stress Granules SIGNED

Using Reconstituted Stress Granules to Gain Insight into the Molecular Pathology of Neurodegenerative Diseases

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 Stress Granules project word cloud

Explore the words cloud of the Stress Granules project. It provides you a very rough idea of what is the project "Stress Granules" about.

biology    mrnas    activating    labs    frontotemporal    uniquely    harmful    generate    first    sclerosis    breaking    critically    human    droplet    turn    academia    neurodegenerative    pauses    lobar    mutations    degeneration    promoted    transition    interactions    time    elucidate    extensive    solidify    behave    gtpase    harnessing    fellowship    sgs    influence    facilities    prevention    assist    cells    leaders    normal    myself    proteins    granule    world    hyman    despite    synthesis    binding    death    components    training    molecular    store    mechanistically    ras    teams    ground    stress    diseases    edge    protein    depends    droplets    health    underlie    cutting    amyotrophic    place    protect    dissect    situated    aggregates    crucially    granules    age    implicated    groups    dynamics    lateral    convert    tool    sg    alberti    little    longer    positioning    cell    association    researcher    physiological    independent    form    minimal    offers    causing    me    resemble    disease    ultimately    vitro    liquid    persist    dissolve    when    expert    career    g3bp1   

Project "Stress Granules" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2021-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 159˙460.00

Map

 Project objective

When cells experience stress, most protein synthesis pauses and so-called stress granules (SGs) form which store and protect mRNAs. SGs are crucial for stress adaptation and prevention of cell death. However, SGs are also implicated in age-related neurodegenerative diseases including amyotrophic lateral sclerosis and frontotemporal lobar degeneration. In these diseases, SGs persist longer than normal and turn into harmful aggregates which cells cannot dissolve.

Despite the importance for human health, we only know very little about how normal SGs convert into disease-causing aggregates. Ground breaking work from the Hyman and Alberti labs could recently demonstrate that SGs behave like liquid droplets which solidify over time. Importantly, this transition is promoted by disease-associated mutations in SG components.

SGs form through protein-protein interactions which critically depends on the Ras GTPase-activating protein-binding protein 1 (G3BP1). The Hyman and Alberti labs could recently generate G3BP1 droplets in vitro and could show that droplet formation is promoted by mRNAs. For the first time, we have a minimal SG system that can be used as a tool to mechanistically dissect SG formation and disease association. I propose harnessing this system to generate complex droplets that resemble physiological SGs. Ultimately, my objective is to elucidate how proteins with disease-causing mutations influence SG properties and dynamics, thus allowing me to identify the molecular changes that underlie neurodegenerative diseases.

The proposed work is to take place in the teams of A Hyman and S Alberti, world leaders in the field of liquid droplets. Both groups are uniquely situated in the same institute which offers cutting-edge facilities and extensive training opportunities. The fellowship would crucially assist me in my future career objective: positioning myself as an expert in the field of granule biology and developing into an independent researcher in academia.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "STRESS GRANULES" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "STRESS GRANULES" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

CoCoNat (2019)

Coordination in constrained and natural distributed systems

Read More  

EVOMET (2019)

The rise and fall of metastatic clones under immune attack

Read More  

STUDYES (2019)

Structure and Ultrafast Dynamics in Deep Eutectic Solvents

Read More