Opendata, web and dolomites

HIV VCC Interference SIGNED

Characterisation of single molecule dynamics within HIV-1 reservoirs as a target for interference with virus persistence and immune evasion

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

Project "HIV VCC Interference" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO PRIVADA INSTITUT DE RECERCA DE LA SIDA-CAIXA 

Organization address
address: CARRETERA DE CANYET
city: BARCELONA
postcode: 8916
website: www.irsicaixa.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO PRIVADA INSTITUT DE RECERCA DE LA SIDA-CAIXA ES (BARCELONA) coordinator 158˙121.00

Map

 Project objective

Human Immunodeficiency Virus type 1 (HIV-1) remains a significant cause of comorbidity and mortality around the world. One of HIV-1 persistence and immune evasion mechanisms is the ability to create hidden virus reservoirs in cells. These virus reservoirs, termed Virus-Containing Compartments (VCCs) are inaccessible to the immune system and help to spread the infection to different parts of the body. VCCs are unaffected by current HIV-1 therapies, and thus remain a major obstacle in the development of successful HIV-1 cure strategies. This project will take a novel approach to the interference with this mechanism of HIV-1 persistence by characterising and exploiting unique molecular dynamics inside VCCs in dendritic cells. Cutting edge super-resolution microscopy techniques enable the study of single molecule behaviour and have already been employed to investigate the minute details of virus-cell interactions during HIV-1 assembly, entry and cell-to-cell spread. These interactions were shown to depend on a specific arrangement and mobility of virus and cell molecules suggesting that efficient virus sequestration and release from VCCs may also require a specific distribution and dynamics of interacting lipids and proteins. Specifically, the “HIV VCC Interference” project aims to: 1) characterise the distribution and dynamics of lipids and proteins in VCCs as a whole and at the sites of virus-cell interactions using super-resolution microscopy; 2) assess the unique characteristics of these sites as targets for interference with HIV-1 persistence and to explore the potential of these targets by testing drugs that perturb specific aspects of cell membranes. These studies, which are aligned with objectives of MSCA-IF, will lead to the description of novel single molecule details of VCC environments and the characterisation of a new type of HIV-1 therapy that targets virus persistence by interfering with unique membrane properties of virus reservoirs.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "HIV VCC INTERFERENCE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "HIV VCC INTERFERENCE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

FOCUSIS (2020)

Focal volume Control Using Structured Illumination Sources

Read More  

MingleIFT (2020)

Multi-color and single-molecule fluorescence imaging of intraflagellar transport in the phasmid chemosensory cilia of C. Elegans

Read More  

MathematicsAnalogies (2019)

Mathematics Analogies

Read More