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TransWNV SIGNED

A transcriptomic approach to understand the avian genetic susceptibility to West Nile Virus infection

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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0

 TransWNV project word cloud

Explore the words cloud of the TransWNV project. It provides you a very rough idea of what is the project "TransWNV" about.

poorly    intervention    individual    global    resume    eurasian    understand    expression    scientific    nile    fellowship    differential    influenced    prof    die    complete    obtaining    mechanisms    opportunity    quail    host    sparrow    virus    wildlife    carry    candidate    examine    pose    ecology    ntilde    inoculated    individuals    genetic    strains    wnv    birds    bioinformatics    marie    dynamics    agent    worldwide    diseases    infects    humans    health    profiles    infectious    gain    house    genomics    yield    immune    union    causative    disease    encephalitis    supervision    ana    immunology    career    basis    first    uncover    infection    susceptibility    station    emerging    avian    do    figuerola    strategies    west    transcriptional    sklodowska    reservoir    critical    insights    collared    sparrows    variation    viral    biological    underlying    integrate    curie    survive    profile    statistical    analyze    genes    species    dove    hosts   

Project "TransWNV" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2018
 Duration (year-month-day) from 2018-10-15   to  2020-10-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 170˙121.00

Map

 Project objective

Emerging infectious diseases that have a wildlife reservoir pose a major challenge to global health. This is the case for West Nile Virus (WNV), which is the number one causative agent of viral encephalitis worldwide. Although it infects humans, the main hosts of WNV are birds. Thus, to develop effective intervention strategies it is critical to understand the disease dynamics in birds. In WNV, disease dynamics are influenced by variation in disease susceptibility across individuals and species, but the factors underlying this variation are poorly understood. Here, I propose to focus on one of these factors: the genetic basis of the immune response. Specifically, I will characterize the transcriptional response to WNV infection and identify candidate genes and pathways that will allow us to gain insights into the avian immune response to the virus and uncover the genetic basis of susceptibility both at the species and individual level. To achieve this goal, I will first analyze the transcriptional response in individuals of house sparrow that die and individuals that survive a WNV infection and test for differential expression. Second, I will characterize the transcriptional profile of house sparrows inoculated with 4 different strains of WNV. Finally, I will examine transcriptional profiles and test for differential expression in 3 species (house sparrow, Eurasian collared dove and common quail) with different susceptibility to WNV. To complete this work I will use state-of –the-art genomics, bioinformatics and statistical analyses and will integrate knowledge from genomics, disease ecology and immunology. Obtaining a Marie Sklodowska-Curie fellowship to carry out this project under the supervision of Prof. J Figuerola (Doñana Biological Station) will be a unique opportunity to resume my scientific career. This project will also contribute to one of the key research areas in the European Union and will yield new insight into the mechanisms relevant to host health.

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The information about "TRANSWNV" are provided by the European Opendata Portal: CORDIS opendata.

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