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PREMOTHER SIGNED

PREvention of MOther-to-child Transmission of HIV and Syphilis using an Electrochemical Readout based on DNA Switches

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

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Project "PREMOTHER" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA 

Organization address
address: CAMPUS DE LA UAB EDIFICI Q ICN2
city: BELLATERRA (BARCELONA)
postcode: 8193
website: www.icn.cat

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-01-07   to  2021-01-06

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA ES (BELLATERRA (BARCELONA)) coordinator 170˙121.00

Map

 Project objective

Mother-to-child transmission of HIV and Syphilis causes approximately 305,000 fetal and neonatal deaths every year and leaves 215,000 infants at increased risk of dying from prematurity, low-birth-weight or congenital disease. An accurate diagnosis of diagnostic-antibodies and a simple treatment during the first weeks of pregnancy could stop all those deaths.

Here, I propose the development of a new technique to be used to measure antibodies directly in whole blood. These will combine the multiplexed (i.e., multiple tests in parallel on one sample), quantitative performance of laboratory-based tests with the portability and low-cost of point-of-care tests. As the first step, I will design, optimize and test nanometer-scale, DNA-based “switches” that undergo a dramatic change in conformation (closed/open) upon recognizing its target antibody. I will use this conformational change to generate a large, easily measurable electronic (electrochemical) signal, which I will then employ in and validate as laboratory-scale, single-test devices using both purified antibodies and authentic human samples. I will then integrate the set of sensors exhibiting good clinical performances into a single, paper-based microfluidic sample handing device (similar to the home pregnancy test) to generate a low-cost platform capable of measuring multiple diagnostic antibodies in a single finger-prick blood sample.

The final and main goal in the DNA-SPADE project is the development of a working prototype diagnostic device, which I will design accordingly to suggestions/inputs from a variety of possible final users (such as nurses and doctors).

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The information about "PREMOTHER" are provided by the European Opendata Portal: CORDIS opendata.

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