PAMpeR SIGNED
Patroller monocytes as modulators of diabetic retinopathy
Total Cost €
0EC-Contrib. €
0Partnership
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0PAMpeR project word cloud
Explore the words cloud of the PAMpeR project. It provides you a very rough idea of what is the project "PAMpeR" about.
Project "PAMpeR" data sheet
The following table provides information about the project.
| Coordinator |
OSPEDALE SAN RAFFAELE SRL
Organization address contact info |
| Coordinator Country | Italy [IT] |
| Total cost | 180˙277 € |
| EC max contribution | 180˙277 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2017 |
| Funding Scheme | MSCA-IF-EF-SE |
| Starting year | 2018 |
| Duration (year-month-day) | from 2018-05-16 to 2020-05-15 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | OSPEDALE SAN RAFFAELE SRL | IT (MILANO) | coordinator | 180˙277.00 |
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Project objective
'Diabetic retinopathy is the first vascular complication of diabetes and the leading cause of legal blindness among adults in Europe. The fact that diabetic retinopathy is preceded by a long latency period has suggested to us that its natural history could incorporate a phase of vascular repair, active after short duration of diabetes and eventually losing efficacy over time. “Patroller” monocytes, a discrete subpopulation of circulating monocytes, patrol healthy vessels by “crawling” on the endothelium at a speed that is order of magnitude lower than rolling, and at variance with the 'classic' monocyte subset produce preferentially housekeeping and trophic factors rather than inflammatory cytokines. Our preliminary data strongly support a role of patrollers, in protecting and repairing retinal vessels in diabetes; suggest that the beneficial activities are delivered during leukostasis; and indicate that 5 months of diabetes duration activates a healing/protective transcriptional program in patrollers.
I seek to learn whether the biosynthetic profile of patrollers changes in relation to increasing duration of diabetes and evolving retinal vascular damage; and, most importantly, I seek to bring the study of patrollers to clinical investigation.
The Objectives are to: 1. Learn if circulating patrollers adapt their biosynthetic profile to different diabetes duration (3 and 9 months) and to the evolving vascular damage 2. Bring the project to clinical applicability by start setting up a human study that aims to compare and contrast the number of circulating patrollers, as well as selected biosynthetic and functional characteristics of these cells, in T1DM patients with no DR after 4-8 years of DM, in T1DM patients with initial nonproliferative DR, and in healthy control subjects.
The expectation is to capture from endogenous systems the types of molecular actions that protect the vessels in early diabetes; and thus be enabled to mimic, complement, or leverage'
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The information about "PAMPER" are provided by the European Opendata Portal: CORDIS opendata.