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PAMpeR SIGNED

Patroller monocytes as modulators of diabetic retinopathy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 PAMpeR project word cloud

Explore the words cloud of the PAMpeR project. It provides you a very rough idea of what is the project "PAMpeR" about.

actions    relation    rolling    seek    dm    monocyte    setting    subjects    nonproliferative    contrast    diabetic    active    applicability    months    damage    data    investigation    functional    capture    mimic    patrol    diabetes    leverage    subset    beneficial    indicate    delivered    time    housekeeping    patients    cells    variance    suggest    protecting    complement    efficacy    t1dm    first    start    discrete    adapt    types    subpopulation    activates    protective    protect    repairing    human    speed    profile    adults    expectation    classic    preferentially    period    history    healing    enabled    lower    suggested    molecular    latency    preceded    vascular    fact    trophic    complication    patroller    endothelium    blindness    inflammatory    patrollers    magnitude    compare    vessels    retinal    incorporate    initial    natural    biosynthetic    losing    repair    preliminary    healthy    monocytes    transcriptional    retinopathy    dr    clinical    leukostasis    circulating    crawling    endogenous    cytokines   

Project "PAMpeR" data sheet

The following table provides information about the project.

Coordinator
OSPEDALE SAN RAFFAELE SRL 

Organization address
address: VIA OLGETTINA 60
city: MILANO
postcode: 20132
website: www.hsr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 180˙277 €
 EC max contribution 180˙277 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2018
 Duration (year-month-day) from 2018-05-16   to  2020-05-15

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    OSPEDALE SAN RAFFAELE SRL IT (MILANO) coordinator 180˙277.00

Map

 Project objective

'Diabetic retinopathy is the first vascular complication of diabetes and the leading cause of legal blindness among adults in Europe. The fact that diabetic retinopathy is preceded by a long latency period has suggested to us that its natural history could incorporate a phase of vascular repair, active after short duration of diabetes and eventually losing efficacy over time. “Patroller” monocytes, a discrete subpopulation of circulating monocytes, patrol healthy vessels by “crawling” on the endothelium at a speed that is order of magnitude lower than rolling, and at variance with the 'classic' monocyte subset produce preferentially housekeeping and trophic factors rather than inflammatory cytokines. Our preliminary data strongly support a role of patrollers, in protecting and repairing retinal vessels in diabetes; suggest that the beneficial activities are delivered during leukostasis; and indicate that 5 months of diabetes duration activates a healing/protective transcriptional program in patrollers.

I seek to learn whether the biosynthetic profile of patrollers changes in relation to increasing duration of diabetes and evolving retinal vascular damage; and, most importantly, I seek to bring the study of patrollers to clinical investigation.

The Objectives are to: 1. Learn if circulating patrollers adapt their biosynthetic profile to different diabetes duration (3 and 9 months) and to the evolving vascular damage 2. Bring the project to clinical applicability by start setting up a human study that aims to compare and contrast the number of circulating patrollers, as well as selected biosynthetic and functional characteristics of these cells, in T1DM patients with no DR after 4-8 years of DM, in T1DM patients with initial nonproliferative DR, and in healthy control subjects.

The expectation is to capture from endogenous systems the types of molecular actions that protect the vessels in early diabetes; and thus be enabled to mimic, complement, or leverage'

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The information about "PAMPER" are provided by the European Opendata Portal: CORDIS opendata.

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