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Gut-AnorexiaNervosa SIGNED

Metagenomics and metabolomics studies of patients with Anorexia Nervosa to identify intestinal microbial mechanisms contributing to pathogenesis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 Gut-AnorexiaNervosa project word cloud

Explore the words cloud of the Gut-AnorexiaNervosa project. It provides you a very rough idea of what is the project "Gut-AnorexiaNervosa" about.

disease    gut    germ    microbiome    clarifying    causality    20th    transplanted    serum    mice    metabolomics    functional    starvation    combined    carefully    microbiota    fasting    species    eighty    iuml    levels    accurate    pathogenesis    152    highest    avenues    fatality    aberrant    outlined    patients    food    ed    similarly    group    dna    phenotypes    intestinal    consists    catalogues    prognosis    deep    taxonomic    women    extreme    bacteria    gun    mechanistic    hypothesis    samples    bioinformatics    altered    quantitative    metabolome    elucidate    untargeted    metagenomics    background    disorder    body    phenotyped    thoughts    metabolic    suggestive    carries    matched    understand    na    age    shot    self    interactions    perspectives    stools    drug    ve    ing    lipidomics    technologies    sequencing    relate    scrutiny    nervosa    neurological    relates    free    century    gene    microbial    composition    anorexia    human    weight    disorders    biology    explored    obsessive    parts    intense    immune    rate    psychiatric    host    controls    examine    individuals   

Project "Gut-AnorexiaNervosa" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 212˙194 €
 EC max contribution 212˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-10-10   to  2021-01-06

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 212˙194.00

Map

 Project objective

Background: Anorexia nervosa (AN), a complex disorder characterized by self-starvation with obsessive thoughts of food resulting in extreme weight loss, carries the highest fatality rate of any psychiatric disease. There is no evidence that the prognosis of AN has improved throughout the 20th century. The role of an altered gut microbiota in the pathogenesis of various human disorders is under intense scrutiny since gut bacteria contribute to metabolic, neurological and immune pathways in the host. Recent advances in microbial DNA sequencing technologies and advanced bioinformatics combined with access to comprehensive microbial gene catalogues have resulted in accurate quantitative metagenomics analysis of the gut microbiota, the impact of which on host biology can be estimated by untargeted metabolomics. Objectives: At deep taxonomic and functional levels to identify which parts of the gut microbiome are altered in women with drug-naïve AN compared with a group of age-matched controls and to elucidate how an aberrant AN microbiome relates to AN phenotypes through the serum metabolome. Potential causality is explored in germ-free mice transplanted with stools from AN patients and controls. Approach: The study sample consists of 152 carefully phenotyped women. Eighty have AN. Deep shot-gun sequencing of microbial DNA has been done on stools from all women. Similarly, fasting serum samples from all individuals have been analyzed applying state-of-the art untargeted metabolomics and lipidomics. In the outlined research program I will test the hypothesis that an aberrant gut microbiome relate to AN phenotypes via an altered serum metabolome. In mechanistic studies of germ-free mice I will examine if stools from AN patients affect body composition of this species as suggestive evidence of causality of AN gut microbiota. Perspectives: Clarifying intestinal microbiome-metabolome interactions will open novel avenues to understand aspects of AN pathogenesis.

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