Opendata, web and dolomites

Gut-AnorexiaNervosa SIGNED

Metagenomics and metabolomics studies of patients with Anorexia Nervosa to identify intestinal microbial mechanisms contributing to pathogenesis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 Gut-AnorexiaNervosa project word cloud

Explore the words cloud of the Gut-AnorexiaNervosa project. It provides you a very rough idea of what is the project "Gut-AnorexiaNervosa" about.

century    disease    elucidate    microbial    understand    levels    relate    disorder    catalogues    fatality    perspectives    scrutiny    taxonomic    individuals    women    microbiota    immune    nervosa    clarifying    matched    gun    avenues    hypothesis    deep    accurate    species    background    drug    gut    explored    metagenomics    starvation    anorexia    relates    composition    mice    weight    bioinformatics    patients    gene    shot    free    similarly    metabolome    psychiatric    technologies    phenotypes    altered    host    iuml    human    outlined    body    stools    self    highest    ing    biology    sequencing    extreme    food    untargeted    na    germ    age    quantitative    20th    combined    interactions    intestinal    causality    obsessive    eighty    group    suggestive    controls    lipidomics    aberrant    consists    serum    examine    fasting    ed    dna    carefully    disorders    intense    microbiome    functional    bacteria    parts    prognosis    metabolomics    samples    metabolic    rate    152    ve    mechanistic    pathogenesis    phenotyped    transplanted    thoughts    neurological    carries   

Project "Gut-AnorexiaNervosa" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 212˙194 €
 EC max contribution 212˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-10-10   to  2021-01-06

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 212˙194.00

Map

 Project objective

Background: Anorexia nervosa (AN), a complex disorder characterized by self-starvation with obsessive thoughts of food resulting in extreme weight loss, carries the highest fatality rate of any psychiatric disease. There is no evidence that the prognosis of AN has improved throughout the 20th century. The role of an altered gut microbiota in the pathogenesis of various human disorders is under intense scrutiny since gut bacteria contribute to metabolic, neurological and immune pathways in the host. Recent advances in microbial DNA sequencing technologies and advanced bioinformatics combined with access to comprehensive microbial gene catalogues have resulted in accurate quantitative metagenomics analysis of the gut microbiota, the impact of which on host biology can be estimated by untargeted metabolomics. Objectives: At deep taxonomic and functional levels to identify which parts of the gut microbiome are altered in women with drug-naïve AN compared with a group of age-matched controls and to elucidate how an aberrant AN microbiome relates to AN phenotypes through the serum metabolome. Potential causality is explored in germ-free mice transplanted with stools from AN patients and controls. Approach: The study sample consists of 152 carefully phenotyped women. Eighty have AN. Deep shot-gun sequencing of microbial DNA has been done on stools from all women. Similarly, fasting serum samples from all individuals have been analyzed applying state-of-the art untargeted metabolomics and lipidomics. In the outlined research program I will test the hypothesis that an aberrant gut microbiome relate to AN phenotypes via an altered serum metabolome. In mechanistic studies of germ-free mice I will examine if stools from AN patients affect body composition of this species as suggestive evidence of causality of AN gut microbiota. Perspectives: Clarifying intestinal microbiome-metabolome interactions will open novel avenues to understand aspects of AN pathogenesis.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "GUT-ANOREXIANERVOSA" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "GUT-ANOREXIANERVOSA" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

PNAIC (2018)

Positive and Negative Asymmetry in Intergroup Contact: Its Impact on Linguistic Forms of Communication and Physiological Responses

Read More  

POMOC (2019)

Charles IV and the power of marvellous objects

Read More  

NaWaTL (2020)

Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and Iconography

Read More