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Development and characterization of extracellular vesicles an innovative cell-free therapeutical product for treatment of stroke

Total Cost €


EC-Contrib. €






 MEXOM project word cloud

Explore the words cloud of the MEXOM project. It provides you a very rough idea of what is the project "MEXOM" about.

medicine    clinical    evs    stakeholders    disability    civil    societies    unmet    acquire    clinically    academia    candidate    exert    vital    inflammatory    reinforce    acute    vesicles    advancing    stroke    biology    molecule    cargo    extracellular    glp    human    quality    boosted    demonstrated    applicable    host    gmp    treatment    micrornas    vivo    medical    private    worldwide    enrichment    effect    intellectual    leader    assurance    preclinical    policymakers    brain    mechanism    receive    researcher    communication    models    entrepreneurship    failed    mature    msc    scientist    transfer    indicate    stem    grade    independent    mscs    he    public    inflammation    immunomodulatory    innovations    cord    career    molecules    regenerative    action    training    cells    regulations    mesenchymal    experiments    first    vitro    time    highlight    innovation    ischemic    fellowship    property    commercial    cell    transferable    anti    ex    data    manufacturing    world    secreted    deleterious    plays    molecular    preconditioning    industry    skills    small    competences   

Project "MEXOM" data sheet

The following table provides information about the project.


Organization address
address: GALILEILAAN 19
city: NIEL
postcode: 2845
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 160˙800 €
 EC max contribution 160˙800 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2018
 Duration (year-month-day) from 2018-09-03   to  2020-09-02


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CELL-FACTORY BE (NIEL) coordinator 160˙800.00


 Project objective

Stroke is leading cause of long-term disability in Europe and worldwide with no effective treatment so far. Inflammation plays a vital role in brain’s response to ischemic stroke with deleterious consequences during early acute phase. Strong immunomodulatory effect of human mesenchymal stem cell (MSCs) demonstrated in many preclinical stroke models, however, has failed in clinical experiments. Recent preclinical data indicate that MSCs exert their anti-inflammatory effects via secreted extracellular vesicles (EVs) through microRNAs and this potential could be boosted by preconditioning MSCs ex vivo with small molecules. The aim of this Fellowship will be the determination of MSC-EVs anti-inflammatory mechanism of action specific for stroke for the first time.

The Host has developed clinical-grade technology (GLP/GMP) for human cord MSC-EVs manufacturing at large scale with anti-inflammatory action. During this Project the Researcher will receive training-through-research and will investigate the small molecule potential impact on MSC-EVs cargo enrichment with specific microRNAs. Then he will study candidate microRNAs anti-inflammatory potential in vitro on the key brain inflammation cells. The Researcher will acquire transferable knowledge in regulations, quality assurance, intellectual property and entrepreneurship. Novel competences will reinforce the Researcher as mature and independent scientist in the field of regenerative medicine with new career opportunities in private sector. Communication and dissemination will be carried out with all stakeholders, including academia, industry, civil societies, policymakers and general public.

The Researcher will transfer his molecular biology knowledge and skills, thus advancing the development of MSC-EVs product for treatment of stroke at the Host towards clinically applicable commercial innovation. This Fellowship will highlight Europe as world leader in innovations targeting unmet medical needs.

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The information about "MEXOM" are provided by the European Opendata Portal: CORDIS opendata.

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