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Multiple Sclerosis SIGNED

Development of a Functionalised Biomaterial Scaffold to Treat Multiple Sclerosis

Total Cost €


EC-Contrib. €






 Multiple Sclerosis project word cloud

Explore the words cloud of the Multiple Sclerosis project. It provides you a very rough idea of what is the project "Multiple Sclerosis" about.

john    affairs    fabricate    intellectual    functionalized    biocompatibility    sectorial    network    annual    motivation    independence    cultures    responsive    tnfr1    complementary    slice    evaluation    establishing    translate    loading    ros    model    modest    prof    communication    27    group    dr    total    leadership    career    professional    disease    treatments    critically    setting    billion    medical    multifunctional    clinical    me    limited    bioactivity    treatment    multiple    immune    secondment    neurodegenerative    mediated    strategies    central    ms    preclinical    completion    hollow    people    discipline    interventions    transferable    international    device    spheres    maturity    clinic    innovative    inter    dea    modify    demyelinating    symptoms    progression    patients    strategy    optimize    benefit    therapeutic    sclerosis    relapse    modifying    700    nervous    mimics    release    academic    licensed    diseases    progress    neuroprotective    antibody    healthcare    regulatory    collaborative    pandit    organotypic    progressive    trial    crospon    collagen    plan    efficacy    goals    effect    inflammatory    property    chronic    position    training    anti    pathology    cns    cerebral    diversity    skills    profile    reimbursement   

Project "Multiple Sclerosis" data sheet

The following table provides information about the project.


Organization address
city: Galway
postcode: H91

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2020-07-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) coordinator 175˙866.00


 Project objective

Multiple sclerosis (MS) is a chronic inflammatory immune-mediated demyelinating disease of the central nervous system (CNS), which affects 700,000 people in Europe, with total annual healthcare costs of over €27.3 billion. Current available treatments for progressive MS have modest effects on relapse symptoms but do not modify disease progression. Critically there are currently no licensed disease-modifying treatments for progressive MS. My strategy will represent a disease modifying treatment for progressive MS. I will fabricate and optimize the loading and release profile of the an anti-TNFR1 antibody from ROS-responsive collagen spheres, I will assess the biocompatibility, bioactivity, and neuroprotective effect of the anti-TNFR1 antibody functionalized ROS-responsive collagen hollow spheres in organotypic cerebral slice cultures. I will evaluate the efficacy of the anti-TNFR1 multifunctional spheres against chronic neurodegenerative pathology in a preclinical model of progressive MS that mimics the pathology seen in progressive MS patients. Progress to completion will be reviewed by a Research and Professional Development Plan which will provide both discipline-specific and complementary technical training and generic and complementary transferable skills training (intellectual property, leadership skills, motivation skills, communication skills, regulatory affairs, clinical trial design, reimbursement strategies, medical device evaluation and regulatory affairs). I will benefit from Prof Pandit’s and Dr John O’Dea’s (Crospon Limited) (inter-sectorial secondment) international collaborative network in the field of neurodegenerative diseases. This training will facilitate me to achieve my future career goals of achieving a position of professional maturity, diversity and independence by establishing my own research group at a leading European academic institution and enable me to translate innovative therapeutic interventions to the clinic setting.

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The information about "MULTIPLE SCLEROSIS" are provided by the European Opendata Portal: CORDIS opendata.

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