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Multiple Sclerosis SIGNED

Development of a Functionalised Biomaterial Scaffold to Treat Multiple Sclerosis

Total Cost €

0

EC-Contrib. €

0

Partnership

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 Multiple Sclerosis project word cloud

Explore the words cloud of the Multiple Sclerosis project. It provides you a very rough idea of what is the project "Multiple Sclerosis" about.

career    symptoms    interventions    chronic    critically    fabricate    immune    dr    cultures    optimize    professional    effect    treatments    reimbursement    medical    network    bioactivity    disease    diversity    multifunctional    700    mediated    clinical    biocompatibility    property    affairs    regulatory    efficacy    group    responsive    establishing    licensed    relapse    skills    strategy    training    academic    sectorial    position    slice    model    modest    transferable    mimics    spheres    john    pathology    modify    dea    progression    motivation    hollow    healthcare    27    preclinical    innovative    profile    progressive    inter    prof    progress    people    billion    anti    total    collaborative    collagen    plan    secondment    benefit    central    cns    therapeutic    organotypic    diseases    crospon    device    completion    multiple    independence    leadership    discipline    patients    tnfr1    neurodegenerative    loading    limited    evaluation    goals    communication    cerebral    maturity    trial    setting    translate    antibody    treatment    strategies    intellectual    inflammatory    modifying    ros    neuroprotective    complementary    functionalized    annual    nervous    pandit    me    release    sclerosis    demyelinating    clinic    international    ms   

Project "Multiple Sclerosis" data sheet

The following table provides information about the project.

Coordinator
NATIONAL UNIVERSITY OF IRELAND GALWAY 

Organization address
address: UNIVERSITY ROAD
city: Galway
postcode: H91
website: www.nuigalway.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2020-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) coordinator 175˙866.00

Map

 Project objective

Multiple sclerosis (MS) is a chronic inflammatory immune-mediated demyelinating disease of the central nervous system (CNS), which affects 700,000 people in Europe, with total annual healthcare costs of over €27.3 billion. Current available treatments for progressive MS have modest effects on relapse symptoms but do not modify disease progression. Critically there are currently no licensed disease-modifying treatments for progressive MS. My strategy will represent a disease modifying treatment for progressive MS. I will fabricate and optimize the loading and release profile of the an anti-TNFR1 antibody from ROS-responsive collagen spheres, I will assess the biocompatibility, bioactivity, and neuroprotective effect of the anti-TNFR1 antibody functionalized ROS-responsive collagen hollow spheres in organotypic cerebral slice cultures. I will evaluate the efficacy of the anti-TNFR1 multifunctional spheres against chronic neurodegenerative pathology in a preclinical model of progressive MS that mimics the pathology seen in progressive MS patients. Progress to completion will be reviewed by a Research and Professional Development Plan which will provide both discipline-specific and complementary technical training and generic and complementary transferable skills training (intellectual property, leadership skills, motivation skills, communication skills, regulatory affairs, clinical trial design, reimbursement strategies, medical device evaluation and regulatory affairs). I will benefit from Prof Pandit’s and Dr John O’Dea’s (Crospon Limited) (inter-sectorial secondment) international collaborative network in the field of neurodegenerative diseases. This training will facilitate me to achieve my future career goals of achieving a position of professional maturity, diversity and independence by establishing my own research group at a leading European academic institution and enable me to translate innovative therapeutic interventions to the clinic setting.

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The information about "MULTIPLE SCLEROSIS" are provided by the European Opendata Portal: CORDIS opendata.

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