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Multiple Sclerosis SIGNED

Development of a Functionalised Biomaterial Scaffold to Treat Multiple Sclerosis

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 Multiple Sclerosis project word cloud

Explore the words cloud of the Multiple Sclerosis project. It provides you a very rough idea of what is the project "Multiple Sclerosis" about.

disease    effect    prof    completion    clinical    sclerosis    setting    people    innovative    training    spheres    neuroprotective    skills    mimics    licensed    chronic    profile    maturity    discipline    relapse    progress    hollow    motivation    patients    annual    700    progressive    international    progression    demyelinating    property    leadership    diseases    device    neurodegenerative    preclinical    total    therapeutic    loading    mediated    translate    healthcare    anti    multifunctional    collaborative    crospon    professional    interventions    nervous    regulatory    optimize    cns    billion    critically    pathology    modify    medical    symptoms    group    diversity    tnfr1    position    secondment    establishing    benefit    immune    model    me    career    27    cerebral    trial    modest    john    multiple    affairs    sectorial    strategies    fabricate    modifying    cultures    evaluation    treatments    organotypic    independence    efficacy    academic    treatment    clinic    ros    slice    responsive    inflammatory    communication    dr    strategy    limited    complementary    reimbursement    pandit    inter    goals    bioactivity    ms    functionalized    intellectual    transferable    central    network    dea    collagen    antibody    release    biocompatibility    plan   

Project "Multiple Sclerosis" data sheet

The following table provides information about the project.

Coordinator
NATIONAL UNIVERSITY OF IRELAND GALWAY 

Organization address
address: UNIVERSITY ROAD
city: Galway
postcode: H91
website: www.nuigalway.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2020-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) coordinator 175˙866.00

Map

 Project objective

Multiple sclerosis (MS) is a chronic inflammatory immune-mediated demyelinating disease of the central nervous system (CNS), which affects 700,000 people in Europe, with total annual healthcare costs of over €27.3 billion. Current available treatments for progressive MS have modest effects on relapse symptoms but do not modify disease progression. Critically there are currently no licensed disease-modifying treatments for progressive MS. My strategy will represent a disease modifying treatment for progressive MS. I will fabricate and optimize the loading and release profile of the an anti-TNFR1 antibody from ROS-responsive collagen spheres, I will assess the biocompatibility, bioactivity, and neuroprotective effect of the anti-TNFR1 antibody functionalized ROS-responsive collagen hollow spheres in organotypic cerebral slice cultures. I will evaluate the efficacy of the anti-TNFR1 multifunctional spheres against chronic neurodegenerative pathology in a preclinical model of progressive MS that mimics the pathology seen in progressive MS patients. Progress to completion will be reviewed by a Research and Professional Development Plan which will provide both discipline-specific and complementary technical training and generic and complementary transferable skills training (intellectual property, leadership skills, motivation skills, communication skills, regulatory affairs, clinical trial design, reimbursement strategies, medical device evaluation and regulatory affairs). I will benefit from Prof Pandit’s and Dr John O’Dea’s (Crospon Limited) (inter-sectorial secondment) international collaborative network in the field of neurodegenerative diseases. This training will facilitate me to achieve my future career goals of achieving a position of professional maturity, diversity and independence by establishing my own research group at a leading European academic institution and enable me to translate innovative therapeutic interventions to the clinic setting.

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The information about "MULTIPLE SCLEROSIS" are provided by the European Opendata Portal: CORDIS opendata.

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