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Multiple Sclerosis SIGNED

Development of a Functionalised Biomaterial Scaffold to Treat Multiple Sclerosis

Total Cost €


EC-Contrib. €






 Multiple Sclerosis project word cloud

Explore the words cloud of the Multiple Sclerosis project. It provides you a very rough idea of what is the project "Multiple Sclerosis" about.

therapeutic    cns    collagen    complementary    billion    inflammatory    optimize    secondment    ms    modifying    pathology    healthcare    collaborative    clinic    pandit    treatments    biocompatibility    patients    700    network    maturity    medical    dea    progression    organotypic    disease    bioactivity    relapse    trial    progressive    central    establishing    property    people    functionalized    inter    dr    treatment    completion    innovative    slice    licensed    leadership    communication    critically    model    clinical    effect    neurodegenerative    diversity    antibody    annual    cultures    preclinical    sclerosis    cerebral    ros    independence    multiple    symptoms    intellectual    total    mimics    profile    27    fabricate    transferable    demyelinating    loading    professional    modest    immune    setting    academic    prof    multifunctional    translate    sectorial    reimbursement    responsive    regulatory    device    evaluation    neuroprotective    goals    interventions    training    release    diseases    me    modify    discipline    nervous    international    hollow    strategy    group    affairs    mediated    limited    spheres    career    crospon    skills    anti    chronic    efficacy    john    position    plan    progress    tnfr1    strategies    benefit    motivation   

Project "Multiple Sclerosis" data sheet

The following table provides information about the project.


Organization address
city: Galway
postcode: H91

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 175˙866 €
 EC max contribution 175˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2020-07-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) coordinator 175˙866.00


 Project objective

Multiple sclerosis (MS) is a chronic inflammatory immune-mediated demyelinating disease of the central nervous system (CNS), which affects 700,000 people in Europe, with total annual healthcare costs of over €27.3 billion. Current available treatments for progressive MS have modest effects on relapse symptoms but do not modify disease progression. Critically there are currently no licensed disease-modifying treatments for progressive MS. My strategy will represent a disease modifying treatment for progressive MS. I will fabricate and optimize the loading and release profile of the an anti-TNFR1 antibody from ROS-responsive collagen spheres, I will assess the biocompatibility, bioactivity, and neuroprotective effect of the anti-TNFR1 antibody functionalized ROS-responsive collagen hollow spheres in organotypic cerebral slice cultures. I will evaluate the efficacy of the anti-TNFR1 multifunctional spheres against chronic neurodegenerative pathology in a preclinical model of progressive MS that mimics the pathology seen in progressive MS patients. Progress to completion will be reviewed by a Research and Professional Development Plan which will provide both discipline-specific and complementary technical training and generic and complementary transferable skills training (intellectual property, leadership skills, motivation skills, communication skills, regulatory affairs, clinical trial design, reimbursement strategies, medical device evaluation and regulatory affairs). I will benefit from Prof Pandit’s and Dr John O’Dea’s (Crospon Limited) (inter-sectorial secondment) international collaborative network in the field of neurodegenerative diseases. This training will facilitate me to achieve my future career goals of achieving a position of professional maturity, diversity and independence by establishing my own research group at a leading European academic institution and enable me to translate innovative therapeutic interventions to the clinic setting.

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The information about "MULTIPLE SCLEROSIS" are provided by the European Opendata Portal: CORDIS opendata.

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