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SZFunc SIGNED

Functional Analysis of Schizophrenia Risk Gene RBM12

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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Project "SZFunc" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 269˙857 €
 EC max contribution 269˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-GF
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 269˙857.00
2    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US (OAKLAND CA) partner 0.00

Map

 Project objective

Schizophrenia is a devastating disease with high societal costs. However, little is known about the biological mechanisms behind the disorder, a knowledge gap that has stalled the development of new treatments. We recently discovered that truncating mutations in RBM12, an RNA binding protein, are associated with schizophrenia. This finding provides a novel entry point to understanding the disease, but fully exploiting the discovery requires further examination of the function of RBM12. Here I propose to begin that effort by using the zebrafish model system to first, determine the role of RBM12 in brain development; second, discover the role of RBM12 in brain function as assessed by functional connectivity and behavioural assays; and third, identify RBM12’s direct and indirect targets using RNA-seq and iCLIP (individual-nucleotide resolution cross-linking and immunoprecipitation). These studies will aid in illuminating the biological basis of schizophrenia and, ultimately, lead to novel treatments.

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The information about "SZFUNC" are provided by the European Opendata Portal: CORDIS opendata.

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