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Rotaxane-DNA SIGNED

Rotaxane-Oligonucleotides: Stimuli-Responsive Mechanically Interlocked Architectures to Control Oligonucleotide Activity and Gene Transcription

Total Cost €

EC-Contrib. €

Partnership

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Rotaxane-DNA project word cloud

Explore the words cloud of the Rotaxane-DNA project. It provides you a very rough idea of what is the project "Rotaxane-DNA" about.

interlocked mimics utilize dnas threading linking stoddart links natural sirna prof components mechanical examples mentor gene sauvage offers wraps demonstrated biology molecular fellowship bases versatile awarded onto goldup molecules generation nobel tools recently oligonucleotides macrocycle dna biological nucleic identically molecule ring create mimic behaves prize machines chemistry culminating presenting replaced regulate 2016 expression rotaxanes triazole combining function opportunity phosphate rotaxane bond famous therapeutic first perhaps shaped chemical acid

Project "Rotaxane-DNA" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY OF SOUTHAMPTON Organization address address: Highfield city: SOUTHAMPTON postcode: SO17 1BJ website: http://www.southampton.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-EF-ST
Starting year	2018
Duration (year-month-day)	from 2018-06-07 to 2020-06-06

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY OF SOUTHAMPTON UNIVERSITY OF SOUTHAMPTON Organization address address: Highfield city: SOUTHAMPTON postcode: SO17 1BJ website: http://www.southampton.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SOUTHAMPTON)	coordinator	183˙454.00

Map

Project objective

Recently, DNA-mimics have been developed in which a natural phosphate unit linking the DNA bases is replaced with a non-natural triazole. This DNA-mimic behaves identically to natural DNA, presenting an opportunity I will exploit during this Fellowship: my mentor, Prof Goldup, has developed chemistry that wraps a ring-shaped molecule (macrocycle) around such triazole links to produce interlocked molecules called rotaxanes. These molecules are perhaps most famous as components of molecular machines, culminating in the 2016 Nobel Prize for chemistry part-awarded to Stoddart and Sauvage, but the mechanical bond also offers opportunities to control the chemistry of the interlocked components.

Combining these approaches, I will create interlocked rotaxane-DNAs to study how threading the macrocycle onto DNA affects the biological function of the nucleic acid. During this Fellowship I will develop the first generation of rotaxane-oligonucleotides, study their properties and utilize the mechanical bond to regulate their biological activity. These interlocked oligonucleotides will be demonstrated as versatile new tools for chemical biology through examples of controlled gene expression and therapeutic siRNA applications.

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The information about "ROTAXANE-DNA" are provided by the European Opendata Portal: CORDIS opendata.