Opendata, web and dolomites

VulneraBAP1 SIGNED

Mechanism and vulnerability of BAP1 loss in tumor metastasis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 VulneraBAP1 project word cloud

Explore the words cloud of the VulneraBAP1 project. It provides you a very rough idea of what is the project "VulneraBAP1" about.

phd    renal    supervise    gene    tumors    pe    pbrm1    genetic    nat    elusive    ccrccs    aggressiveness    exclusive    metastases    patients    characterization    cell    aggressive    genet    75    implications    repression    first    metastasis    synthetic    lower    mtorc1    group    strategy    metastasize    15    induces    binds    whereas    independent    leader    prone    subtype    prevalent    mutations    surgery    kidney    cancers    ten    discovered    countries    identification    pathological    clinical    poorer    arising    classification    bap1    llopis    grant    investigator    protein    therapeutic    notably    vulnerabilities    diagnosis    carcinoma    mechanism    cluster    awarded    grade    mutually    found    patient    2012    suppressor    metastatic    promoter    tangible    lethality    survival    inactivated    brca1    ntilde    western    clear    career    ccrcc    incurable    cancer    al    mirna    largely    30    display    attainment    student    et    uncover    molecular    tumor    disease    frequent    activation   

Project "VulneraBAP1" data sheet

The following table provides information about the project.

Coordinator
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG 

Organization address
address: IM NEUENHEIMER FELD 280
city: HEIDELBERG
postcode: 69120
website: www.dkfz.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG DE (HEIDELBERG) coordinator 171˙460.00

Map

 Project objective

Kidney cancer is among the ten most prevalent cancers arising in Western countries, with clear-cell renal cell carcinoma (ccRCC) being the most frequent subtype (75%). About 30% of ccRCC patients present with metastatic disease at diagnosis, and another 30% will develop metastases after surgery. When metastatic, ccRCC remains largely incurable.

I recently discovered that the tumor suppressor BAP1 (BRCA1-associated protein 1) is inactivated in 15% of ccRCCs (Peña-Llopis et al. Nat. Genet. 2012). Notably, I found that mutations in BAP1 are mutually exclusive with mutations of the tumor suppressor gene PBRM1, and loss of BAP1 was associated with higher tumor grade, activation of mTORC1, and poorer overall patient survival, whereas tumors with PBRM1 loss were associated with lower tumor grade and better overall survival. This first molecular genetic classification of ccRCC may have tangible clinical implications, since tumors with BAP1 loss display in general more aggressive pathological features and are more prone to metastasize. However, the molecular mechanism through which BAP1 loss induces metastasis and tumor aggressiveness remains elusive.

In this study, I aim to investigate the molecular mechanism of repression of a miRNA cluster involved in metastasis by BAP1 and identify therapeutic opportunities. Specifically, I will (1) supervise a PhD student (supported by a grant I was recently been awarded) in the identification and characterization of the BAP1 protein complex that binds at the miRNA cluster promoter; and (2) I will uncover the genetic vulnerabilities of BAP1 loss by a synthetic lethality strategy. These studies will facilitate attainment of my long term career goal to become a group leader and a fully independent investigator.

 Publications

year authors and title journal last update
List of publications.
2019 Max Fleischmann, Daniel Martin, Samuel Peña-Llopis, Julius Oppermann, Jens von der Grün, Markus Diefenhardt, Georgios Chatzikonstantinou, Emmanouil Fokas, Claus Rödel, Klaus Strebhardt, Sven Becker, Franz Rödel, Nikolaos Tselis
Association of Polo-Like Kinase 3 and PhosphoT273 Caspase 8 Levels With Disease-Related Outcomes Among Cervical Squamous Cell Carcinoma Patients Treated With Chemoradiation and Brachytherapy
published pages: , ISSN: 2234-943X, DOI: 10.3389/fonc.2019.00742
Frontiers in Oncology 9 2020-01-29

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "VULNERABAP1" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "VULNERABAP1" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

EVOMET (2019)

The rise and fall of metastatic clones under immune attack

Read More  

TOPOCIRCUS (2019)

Simulations of Topological Phases in Superconducting Circuits

Read More  

INFANTPATTERNS (2019)

Development of kinematic and muscle patterns in preterm infants

Read More