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MechaDynA SIGNED

Multi-scale mechanics of dynamic leukocyte adhesion

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MechaDynA project word cloud

Explore the words cloud of the MechaDynA project. It provides you a very rough idea of what is the project "MechaDynA" about.

inflammation    length    physics    multiple    perform    speed    hs    biomedically    protein    traps    physiologically    samples    spectroscopy    dynamic    nm    biological    sub    door    vessel    picture    site    minutes    afm    widest    tools    leukocyte    min    vessels    time    phenomena    patrol    soft    vascular    diagnosis    single    optical    obtaining    blood    parallel    proposes    atomic    cascade    velocities    lack    migrate    nanotools    cell    outcomes    techniques    mechanics    msec    explored    binding    acoustic    probe    mm    particles    mechanical    search    strength    membrane    resolution    cytoskeleton    force    microscopy    cells    living    afs    scales    microsec    physical    leukocytes    temporal    adhesion    immune    mechanistic    biology    molecules    hours    complexes    subjected    roll    hundreds    wall    coupling    micro    description    unexplored    white    mechadyna    sites    forces    technologically    flowing    therapeutics    complete    condensed   

Project "MechaDynA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE D'AIX MARSEILLE 

Organization address
address: Boulevard Charles Livon 58
city: Marseille
postcode: 13284
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙068˙959 €
 EC max contribution 2˙068˙959 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE D'AIX MARSEILLE FR (Marseille) coordinator 2˙068˙959.00

Map

 Project objective

Leukocytes, white blood cells, patrol the vascular wall of our vessels in search of sites of inflammation. In the so-called leukocyte adhesion cascade, leukocytes flowing at high velocities (up to mm/s) impact the vessel wall, roll at µm/s, and finally migrate at nm/s to the site of inflammation. They are thus subjected to mechanical forces from sub-msec to several minutes. Complete understanding of the physical processes behind leukocyte adhesion requires an approach over multiple length and time scales, from single protein molecules to the whole cell. This is far from being established due, in part, to the lack of techniques covering the wide range of length and time scales involved. We have recently implemented high-speed atomic force microscopy (HS-AFM) to perform force spectroscopy measurements on biological samples with microsec time resolution. The novel acoustic force spectroscopy (AFS) traps hundreds of particles in parallel allowing hours-long measurements on single molecules. MechaDynA proposes to develop and apply these two novel nanotools to allow force measurements on living cells with the goal of obtaining a complete, multi-scale picture of the physics behind the leukocyte adhesion cascade over the widest dynamic range (µs-min). This will require development of HS-AFM technology and coupling with advanced optical microscopy. We will probe the binding strength of single adhesion complexes, and membrane and cytoskeleton mechanics at physiologically relevant time scales not explored so far. Technologically, it will establish HS-AFM and AFS as force measurement tools for living cells covering the widest temporal range. This will open the door to unexplored physical phenomena in cell biology, biological physics and soft condensed matter. Biomedically, the expected outcomes will provide a mechanistic description of the physical phenomena in leukocyte immune response that may lead to better diagnosis and therapeutics.

 Publications

year authors and title journal last update
List of publications.
2019 Marianthi Karageorgi, Simon C. Groen, Fidan Sumbul, Julianne N. Pelaez, Kirsten I. Verster, Jessica M. Aguilar, Amy P. Hastings, Susan L. Bernstein, Teruyuki Matsunaga, Michael Astourian, Geno Guerra, Felix Rico, Susanne Dobler, Anurag A. Agrawal, Noah K. Whiteman
Genome editing retraces the evolution of toxin resistance in the monarch butterfly
published pages: 409-412, ISSN: 0028-0836, DOI: 10.1038/s41586-019-1610-8
Nature 574/7778 2020-03-05
2019 Claire Valotteau, Fidan Sumbul, Felix Rico
High-speed force spectroscopy: microsecond force measurements using ultrashort cantilevers
published pages: 689-699, ISSN: 1867-2450, DOI: 10.1007/s12551-019-00585-4
Biophysical Reviews 11/5 2019-11-22

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