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Paget-Advance SIGNED

Advancing knowledge to improve outcome in Paget’s disease of bone

Total Cost €

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EC-Contrib. €

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Partnership

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Project "Paget-Advance" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EDINBURGH 

Organization address
address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL
website: www.ed.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙422˙623 €
 EC max contribution 2˙422˙623 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2023-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 2˙422˙623.00

Map

 Project objective

Paget’s disease of bone (PDB) is a common skeletal disorder in people of European descent characterised by abnormal bone remodeling which disrupts normal bone structure causing pain, deformity, nerve compression syndromes and fractures.

The causes of PDB are incompletely understood. Genetic factors play a key role and some predisposing genes been identified but many remain to be discovered as do the mechanisms by which these genes influence bone cell function. Environmental factors also contribute but these are poorly defined, and it remains unclear how genes and environment interact to regulate susceptibility and severity. Further research is required to permit earlier diagnosis and to define the genetic and environmental factors that influence susceptibility to PDB so that new therapeutic strategies can be developed to improve outcome.

The Paget-Advance programme will progress beyond state-of-the-art by identifying new genetic variants that predispose to PDB by extended genome wide association studies and next generation sequencing of early onset familial cases where the causal genes are unknown. A genetic profiling test will be developed to facilitate early diagnosis and treatment. The functional mechanisms by which the variants affect bone cell function will be investigated using bioinformatics, cell culture studies and preclinical disease models. Potential environmental triggers will be explored focusing on the intestinal microbiome diet and biomechanical loading using preclinical disease models and prospective clinical studies.

The result will be to increase understanding of PDB and to facilitate earlier diagnosis and timely therapeutic intervention which will improve clinical outcome for patients and those at risk of the disease. The research will also have wider significance in advancing knowledge of the fundamental processes that regulate bone remodelling with potential spinoffs for other bone diseases.

 Publications

year authors and title journal last update
List of publications.
2019 Stuart H Ralston, Luis Corral-Gudino, Cyrus Cooper, Roger M Francis, William D Fraser, Luigi Gennari, Núria Guañabens, M Kassim Javaid, Robert Layfield, Terence W O\'Neill, R Graham G Russell, Michael D Stone, Keith Simpson, Diana Wilkinson, Ruth Wills, M Carola Zillikens, Stephen P Tuck
Diagnosis and Management of Paget\'s Disease of Bone in Adults: A Clinical Guideline
published pages: e3657, ISSN: 0884-0431, DOI: 10.1002/jbmr.3657
Journal of Bone and Mineral Research 34/4 2019-06-06

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The information about "PAGET-ADVANCE" are provided by the European Opendata Portal: CORDIS opendata.

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