Opendata, web and dolomites

IMMUNEDIVERSITY SIGNED

Defining of human adaptive immune gene diversity and its impact on disease

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 IMMUNEDIVERSITY project word cloud

Explore the words cloud of the IMMUNEDIVERSITY project. It provides you a very rough idea of what is the project "IMMUNEDIVERSITY" about.

met    diversity    body    receptor    fact    elucidate    cannot    genes    computational    human    antibodies    allergy    gt    arthritis    igdiscover    sequencing    of    answer    diseases    molecular    germline    software    lies    rearrange    tolerate    lymphocytes    diabetes    ig    encode    deletions    complexity    databases    lifetimes    cell    iuml    immune    conventional    neutralizing    associations    encompassing    repertoire    genetic    personalized    copy    heterogeneity    rheumatoid    preparation    individual    enormous    degree    ve    self    histocompatibility    generation    recognition    repetitiveness    antigens    hundreds    describes    receptors    sclerosis    potent    adequately    protect    segments    library    offers    infections    profiling    genome    genomic    appreciated    throughput    people    vaccines    insertions    complexes    individuals    encoding    possibilities    regions    polymorphic    adaptive    antibody    variations    immunediscover    all    why    construction    na    express    global    uncovering    multiple    gene    1000    rapid    loci   

Project "IMMUNEDIVERSITY" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-12-01   to  2023-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 2˙500˙000.00

Map

 Project objective

Why do vaccines protect some people but not all? Why can some people develop potent neutralizing antibodies to infections, while others cannot? Why do some people develop immune-associated diseases such as allergy, rheumatoid arthritis, multiple sclerosis and diabetes over their lifetimes, when the body has evolved to tolerate self? The answer lies in the adaptive immune system. B and T lymphocytes of the adaptive system express highly polymorphic receptors that allow for the recognition of large numbers of antigens. Our research is now uncovering an enormous heterogeneity in the germline genes that encode our B and T cell receptors. This fact has not been well appreciated because of the high complexity of the genomic regions that encode these receptors, with the presence of large insertions and deletions, a high degree of repetitiveness and gene copy number variations, which cannot be adequately met with conventional whole genome sequencing approaches.

We have developed a state-of-the-art approach we call IgDiscover, which comprises novel molecular library preparation approaches, next generation immune repertoire sequencing, computational analysis and a software that allows rapid construction of personalized antibody gene databases encompassing the hundreds of germline gene segments that rearrange to make up each individual’s naïve B cell repertoire. Thus, IgDiscover offers new possibilities to define human genetic diversity in these loci. This proposal also describes our development of ImmuneDiscover, a high throughput approach enabling personalized immune-profiling of very large numbers of individuals (>1000), encompassing not only Ig genes but also T cell receptor genes and the genes encoding the human major histocompatibility complexes. Here, we will use IgDiscover and ImmuneDiscover to elucidate global diversity in adaptive immune genes and we will investigate potential associations between antibody germline genes and the development of rheumatoid arthritis.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "IMMUNEDIVERSITY" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "IMMUNEDIVERSITY" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

PROGRESS (2019)

The Enemy of the Good: Towards a Theory of Moral Progress

Read More  

SuperH (2019)

Discovery and Characterization of Hydrogen-Based High-Temperature Superconductors

Read More  

HOLI (2019)

Deep Learning for Holistic Inference

Read More