Opendata, web and dolomites

IMMUNEDIVERSITY SIGNED

Defining of human adaptive immune gene diversity and its impact on disease

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 IMMUNEDIVERSITY project word cloud

Explore the words cloud of the IMMUNEDIVERSITY project. It provides you a very rough idea of what is the project "IMMUNEDIVERSITY" about.

encode    sclerosis    infections    sequencing    genomic    igdiscover    1000    rheumatoid    germline    copy    uncovering    ve    loci    cell    all    describes    immune    generation    genes    express    genetic    insertions    of    heterogeneity    individuals    polymorphic    databases    neutralizing    encompassing    immunediscover    lifetimes    diseases    segments    iuml    complexes    gt    conventional    antigens    variations    why    allergy    adequately    arthritis    receptors    na    individual    tolerate    complexity    receptor    personalized    repertoire    human    cannot    profiling    elucidate    rearrange    self    lymphocytes    preparation    body    protect    repetitiveness    appreciated    multiple    adaptive    offers    ig    regions    vaccines    hundreds    diabetes    rapid    throughput    construction    recognition    library    associations    genome    fact    degree    software    lies    molecular    possibilities    encoding    gene    antibodies    antibody    people    deletions    histocompatibility    computational    enormous    diversity    potent    met    global    answer   

Project "IMMUNEDIVERSITY" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-12-01   to  2023-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 2˙500˙000.00

Map

 Project objective

Why do vaccines protect some people but not all? Why can some people develop potent neutralizing antibodies to infections, while others cannot? Why do some people develop immune-associated diseases such as allergy, rheumatoid arthritis, multiple sclerosis and diabetes over their lifetimes, when the body has evolved to tolerate self? The answer lies in the adaptive immune system. B and T lymphocytes of the adaptive system express highly polymorphic receptors that allow for the recognition of large numbers of antigens. Our research is now uncovering an enormous heterogeneity in the germline genes that encode our B and T cell receptors. This fact has not been well appreciated because of the high complexity of the genomic regions that encode these receptors, with the presence of large insertions and deletions, a high degree of repetitiveness and gene copy number variations, which cannot be adequately met with conventional whole genome sequencing approaches.

We have developed a state-of-the-art approach we call IgDiscover, which comprises novel molecular library preparation approaches, next generation immune repertoire sequencing, computational analysis and a software that allows rapid construction of personalized antibody gene databases encompassing the hundreds of germline gene segments that rearrange to make up each individual’s naïve B cell repertoire. Thus, IgDiscover offers new possibilities to define human genetic diversity in these loci. This proposal also describes our development of ImmuneDiscover, a high throughput approach enabling personalized immune-profiling of very large numbers of individuals (>1000), encompassing not only Ig genes but also T cell receptor genes and the genes encoding the human major histocompatibility complexes. Here, we will use IgDiscover and ImmuneDiscover to elucidate global diversity in adaptive immune genes and we will investigate potential associations between antibody germline genes and the development of rheumatoid arthritis.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "IMMUNEDIVERSITY" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "IMMUNEDIVERSITY" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

SoftHandler (2019)

Commercial feasibility of an integrated soft robotic system for industrial handling

Read More  

Resonances (2019)

Resonances and Zeta Functions in Smooth Ergodic Theory and Geometry

Read More  

CIRCULAR X (2020)

Experimenting with Circular Service Business Models

Read More