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IMMUNEDIVERSITY SIGNED

Defining of human adaptive immune gene diversity and its impact on disease

Total Cost €

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EC-Contrib. €

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Partnership

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 IMMUNEDIVERSITY project word cloud

Explore the words cloud of the IMMUNEDIVERSITY project. It provides you a very rough idea of what is the project "IMMUNEDIVERSITY" about.

molecular    recognition    vaccines    tolerate    immune    antibodies    preparation    self    conventional    histocompatibility    neutralizing    genes    lifetimes    individual    computational    encompassing    software    regions    iuml    repetitiveness    receptor    fact    why    profiling    encoding    of    variations    library    adequately    insertions    heterogeneity    deletions    describes    cannot    protect    offers    degree    enormous    databases    throughput    ig    segments    global    possibilities    adaptive    elucidate    infections    human    diabetes    met    all    gene    generation    antibody    genetic    copy    immunediscover    hundreds    repertoire    antigens    potent    gt    1000    genome    answer    people    body    igdiscover    personalized    construction    lies    express    allergy    rearrange    polymorphic    diseases    loci    lymphocytes    complexes    receptors    rapid    complexity    multiple    na    associations    rheumatoid    sequencing    encode    germline    ve    appreciated    cell    sclerosis    diversity    genomic    individuals    arthritis    uncovering   

Project "IMMUNEDIVERSITY" data sheet

The following table provides information about the project.

Coordinator
KAROLINSKA INSTITUTET 

Organization address
address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177
website: www.ki.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-12-01   to  2023-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KAROLINSKA INSTITUTET SE (STOCKHOLM) coordinator 2˙500˙000.00

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 Project objective

Why do vaccines protect some people but not all? Why can some people develop potent neutralizing antibodies to infections, while others cannot? Why do some people develop immune-associated diseases such as allergy, rheumatoid arthritis, multiple sclerosis and diabetes over their lifetimes, when the body has evolved to tolerate self? The answer lies in the adaptive immune system. B and T lymphocytes of the adaptive system express highly polymorphic receptors that allow for the recognition of large numbers of antigens. Our research is now uncovering an enormous heterogeneity in the germline genes that encode our B and T cell receptors. This fact has not been well appreciated because of the high complexity of the genomic regions that encode these receptors, with the presence of large insertions and deletions, a high degree of repetitiveness and gene copy number variations, which cannot be adequately met with conventional whole genome sequencing approaches.

We have developed a state-of-the-art approach we call IgDiscover, which comprises novel molecular library preparation approaches, next generation immune repertoire sequencing, computational analysis and a software that allows rapid construction of personalized antibody gene databases encompassing the hundreds of germline gene segments that rearrange to make up each individual’s naïve B cell repertoire. Thus, IgDiscover offers new possibilities to define human genetic diversity in these loci. This proposal also describes our development of ImmuneDiscover, a high throughput approach enabling personalized immune-profiling of very large numbers of individuals (>1000), encompassing not only Ig genes but also T cell receptor genes and the genes encoding the human major histocompatibility complexes. Here, we will use IgDiscover and ImmuneDiscover to elucidate global diversity in adaptive immune genes and we will investigate potential associations between antibody germline genes and the development of rheumatoid arthritis.

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