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ProgrES SIGNED

Programmable Enzymatic Synthesis of Bioactive Compounds

Total Cost €

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EC-Contrib. €

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Partnership

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 ProgrES project word cloud

Explore the words cloud of the ProgrES project. It provides you a very rough idea of what is the project "ProgrES" about.

biocatalyst    biosynthetic    monooxygenases    demands    selective    cascades    throughput    away    found    de    mostly    timescale    match    linked    proof    progres    moving    cascade    diverse    free    biocatalytic    transdisciplinary    organic    databases    intermediates    engineering    biology    diversification    nature    mass    tools    reactions    toolkit    resolution    structural    natural    manual    demonstrated    bottlenecks    simultaneously    complexity    analytical    synthesis    bioinformatics    functionalisation    chemical    sugars    building    synthetic    generating    catalysed    breakthrough    identification    biosynthesis    bottleneck    activation    bed    imino    protein    enzymatic    mediated    few    diversity    stage    label    chemo    catalysts    parallel    spectrometry    generate    novo    biocatalysts    introducing    prior    group    lack    becomes    molecular    reaction    limited    therapeutic    unprecedented    automated    programmable    library    pharmacopeia    scaffolds    enzymes    platform   

Project "ProgrES" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF MANCHESTER 

Organization address
address: OXFORD ROAD
city: MANCHESTER
postcode: M13 9PL
website: www.manchester.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙399˙831 €
 EC max contribution 2˙399˙830 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2023-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) coordinator 2˙399˙830.00

Map

 Project objective

Enzymes are now established as highly selective biocatalysts in organic synthesis with the range of catalysts and reactions rapidly increasing through access to large protein databases and high-throughput molecular biology tools for biocatalyst engineering. The diversity of biocatalytic reactions is now at a stage where they can be linked in (chemo)-enzymatic reaction cascades, where two or more chemical and/or enzymatic reactions can be catalysed simultaneously generating de novo biosynthetic pathways for chemical synthesis not found in Nature. These reaction cascades have demonstrated important prior art, however they have been mostly limited to few steps and lack the complexity provided by the natural pharmacopeia. ProgrES aims to achieve a step-change by introducing unprecedented structural complexity into de novo pathways and by moving away from manual to automated, high-throughput cascade design and implementation. The proposal is to use a transdisciplinary approach that addresses three important bottlenecks: i. Identification of enzymatic reactions that allow early functionalisation and late stage diversification of the cascade toolkit to increase structural complexity, building on C-H activation mediated by monooxygenases, which are well established in our research group. ii. As diversity of targets increases, high resolution structural analysis of pathway intermediates and products becomes a bottleneck, which is addressed by high-throughput label free mass spectrometry based analytical tools that will match the demands on timescale and numbers. iii. In parallel, we will establish bioinformatics tools adapted from both chemical synthesis and biosynthesis, to allow programmable enzymatic synthesis for cascade design. As proof-of-concept and test bed for the ProgrES platform we aim to generate a library of diverse synthetic imino sugars. This proposal will lead to a major breakthrough in creating a diverse range of scaffolds of therapeutic interest.

 Publications

year authors and title journal last update
List of publications.
2019 Sebastian C. Cosgrove, Ashley P. Mattey, Michel Riese, Michael R. Chapman, William R. Birmingham, A. John Blacker, Nikil Kapur, Nicholas J. Turner, Sabine L. Flitsch
Biocatalytic Oxidation in Continuous Flow for the Generation of Carbohydrate Dialdehydes
published pages: 11658-11662, ISSN: 2155-5435, DOI: 10.1021/acscatal.9b04819
ACS Catalysis 9/12 2020-03-05
2019 Jack Manning, Michele Tavanti, Joanne L. Porter, Nico Kress, Sam P. De Visser, Nicholas J. Turner, Sabine L. Flitsch
Regio‐ and Enantio‐selective Chemo‐enzymatic C−H‐Lactonization of Decanoic Acid to ( S )‐δ‐Decalactone
published pages: 5724-5727, ISSN: 0044-8249, DOI: 10.1002/ange.201901242
Angewandte Chemie 131/17 2020-03-05
2019 Nicholas J. Weise, Prasansa Thapa, Syed T. Ahmed, Rachel S. Heath, Fabio Parmeggiani, Nicholas J. Turner, Sabine L. Flitsch
Bi‐enzymatic Conversion of Cinnamic Acids to 2‐Arylethylamines
published pages: 995-998, ISSN: 1867-3880, DOI: 10.1002/cctc.201902128
ChemCatChem 12/4 2020-03-05

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