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Role of protein crystallization in type 2 immunity and asthma

Total Cost €


EC-Contrib. €






 ASTHMACRYSTALCLEAR project word cloud

Explore the words cloud of the ASTHMACRYSTALCLEAR project. It provides you a very rough idea of what is the project "ASTHMACRYSTALCLEAR" about.

medical    charcot    asthma    extracellular    activation    eliminate    combines    physiology    molecular    chronic    alternatives    science    chose    murine    physiological    soluble    crystal    crystallization    benefit    antibodies    eosinophilic    full    serves    activated    release    active    chitinase    tool    steroid    patients    therapies    crystallizing    crystalline    clinical    function    rhinosinusitis    inflammation    mice    crystals    disease    accompanied    infection    cells    galectin    prolong    accumulation    danger    immunity    demise    creation    immunology    abundantly    ym1    unknown    spontaneous    airways    eosinophils    signal    alternatively    event    structural    ym2    innovative    amounts    proteins    elution    depleting    macrophages    harmless    view    turn    sequester    understand    hallmark    protein    immunoregulation    biology    rare    structure    frontline    leyden    helminth    integrative    made    hypothesize    eosinophil    slow    markers    human    resistant   

Project "ASTHMACRYSTALCLEAR" data sheet

The following table provides information about the project.


Organization address
postcode: 9052

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 2˙499˙846 €
 EC max contribution 2˙499˙846 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2023-07-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB VZW BE (ZWIJNAARDE - GENT) coordinator 2˙499˙846.00


 Project objective

Spontaneous protein crystallization is a rare event in biology. Eosinophilic inflammation such as seen in the airways in asthma, chronic rhinosinusitis and helminth infection is however accompanied by accumulation of large amounts of extracellular Charcot-Leyden crystals. These are made of Galectin-10, a protein of unknown function produced by eosinophils, hallmark cells of type 2 immunity. In mice, eosinophilic inflammation is also accompanied by protein crystal build up, composed of the chitinase-like proteins Ym1 and Ym2, produced by alternatively activated macrophages. Here we challenge the current view that these crystals are just markers of eosinophil demise or macrophages activation. We hypothesize that protein crystallization serves an active role in immunoregulation of type 2 immunity. On the one hand, crystallization might turn a harmless protein into a danger signal. On the other hand, crystallization might sequester and eliminate the physiological function of soluble Galectin-10 and Ym1, or prolong it via slow release elution. For full understanding, we therefore need to understand the function of the proteins in a soluble and crystalline state. Our program at the frontline of immunology, molecular structural biology and clinical science combines innovative tool creation and integrative research to investigate the structure, function, and physiology of galectin-10 and related protein crystals. We chose to study asthma as the crystallizing proteins are abundantly present in human and murine disease. There is still a large medical need for novel therapies that could benefit patients with chronic steroid-resistant disease, and are alternatives to eosinophil-depleting antibodies whose long term effects are unknown.

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The information about "ASTHMACRYSTALCLEAR" are provided by the European Opendata Portal: CORDIS opendata.

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