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ASTHMACRYSTALCLEAR SIGNED

Role of protein crystallization in type 2 immunity and asthma

Total Cost €

0

EC-Contrib. €

0

Partnership

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 ASTHMACRYSTALCLEAR project word cloud

Explore the words cloud of the ASTHMACRYSTALCLEAR project. It provides you a very rough idea of what is the project "ASTHMACRYSTALCLEAR" about.

charcot    crystal    rare    disease    immunity    ym1    accompanied    antibodies    chose    hypothesize    slow    patients    inflammation    signal    leyden    soluble    science    infection    spontaneous    rhinosinusitis    elution    depleting    tool    prolong    activated    physiology    human    combines    chitinase    medical    active    eliminate    release    chronic    physiological    frontline    protein    turn    airways    steroid    sequester    markers    asthma    understand    macrophages    alternatives    harmless    integrative    crystals    resistant    structure    eosinophils    crystallization    activation    serves    creation    therapies    amounts    function    proteins    benefit    extracellular    unknown    alternatively    eosinophilic    full    eosinophil    danger    crystalline    mice    view    immunoregulation    cells    structural    innovative    ym2    galectin    crystallizing    immunology    biology    demise    accumulation    helminth    event    molecular    abundantly    murine    hallmark    clinical    made   

Project "ASTHMACRYSTALCLEAR" data sheet

The following table provides information about the project.

Coordinator
VIB VZW 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 2˙499˙846 €
 EC max contribution 2˙499˙846 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2023-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB VZW BE (ZWIJNAARDE - GENT) coordinator 2˙499˙846.00

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 Project objective

Spontaneous protein crystallization is a rare event in biology. Eosinophilic inflammation such as seen in the airways in asthma, chronic rhinosinusitis and helminth infection is however accompanied by accumulation of large amounts of extracellular Charcot-Leyden crystals. These are made of Galectin-10, a protein of unknown function produced by eosinophils, hallmark cells of type 2 immunity. In mice, eosinophilic inflammation is also accompanied by protein crystal build up, composed of the chitinase-like proteins Ym1 and Ym2, produced by alternatively activated macrophages. Here we challenge the current view that these crystals are just markers of eosinophil demise or macrophages activation. We hypothesize that protein crystallization serves an active role in immunoregulation of type 2 immunity. On the one hand, crystallization might turn a harmless protein into a danger signal. On the other hand, crystallization might sequester and eliminate the physiological function of soluble Galectin-10 and Ym1, or prolong it via slow release elution. For full understanding, we therefore need to understand the function of the proteins in a soluble and crystalline state. Our program at the frontline of immunology, molecular structural biology and clinical science combines innovative tool creation and integrative research to investigate the structure, function, and physiology of galectin-10 and related protein crystals. We chose to study asthma as the crystallizing proteins are abundantly present in human and murine disease. There is still a large medical need for novel therapies that could benefit patients with chronic steroid-resistant disease, and are alternatives to eosinophil-depleting antibodies whose long term effects are unknown.

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The information about "ASTHMACRYSTALCLEAR" are provided by the European Opendata Portal: CORDIS opendata.

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