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BONE-JOINT-MORPH SIGNED

Mechanobiology of Proprioceptive Regulation of Bone and Joint Morphogenesis

Total Cost €

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EC-Contrib. €

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Partnership

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Project "BONE-JOINT-MORPH" data sheet

The following table provides information about the project.

Coordinator
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 183˙454.00

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 Project objective

Physiological movement, including movement before birth (fetal movement), is necessary for maintaining a proper mechanical environment which will facilitate musculoskeletal development. Developmental dysplasia of the hip (DDH) is a condition which can result due to abnormal loading either before or after birth. With DDH, the acetabular socket is often shallow causing an improper fit of the femoral head within the socket, leading to hip instability or even dislocation. DDH is the most commonly abnormal joint in new-born babies, with an incidence of 4.9 out of 1000. However, it is not known why the hip, more than any other joint in the body, is so dependent on movements and mechanical stimulation for its normal development. Recent studies on the proprioceptive system (the neuromuscular sensory receptors responsible for registering position and movement of body parts) have indicated a key role in skeletogenesis. Disruption of the proprioceptive system in mice through knocking out Runt-related transcription factor 3 (RUNX3 KO) has been found to cause gait ataxia, spinal scoliosis and fracture misalignment. Excitingly, unpublished data from the same animal model has indicated that hip dysplasia consistently occurs in these mice, with all other synovial joints forming normally. It is hypothesised that the hip joint abnormalities arise as a direct effect of the abnormal mechanical environment due to abnormal gait. Therefore, this model system offers a unique opportunity to reveal how movement shapes the developing joint, and in particular, why the hip joint is more dependent on normal movements than any other joint. Therefore, this project will potentially reveal new insights into the causes and aetiology of DDH.

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