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Achilles SIGNED

Overcoming specific weaknesses in tendon biology to design advanced regenerative therapies

Total Cost €


EC-Contrib. €






 Achilles project word cloud

Explore the words cloud of the Achilles project. It provides you a very rough idea of what is the project "Achilles" about.

nuig    modular    therapies    translate    unleash    compete    strengthen    cell    excellent    tissue    trauma    generating    therapy    outstanding    sustainably    excellence    mayo    molecular    internationally    gaps    regensburg    constant    group    minho    human    uminho    twinning    surgery    3b    staff    university    capability    therapeutic    international    sustainability    networking    strategies    shows    clinic    create    intellectual    engineering    disorders    positioning    complemented    treat    competitiveness    biophysics    organization    profile    tendon    sharing    visibility    reinforce    translation    medicine    tine    sustained    significantly    quality    biology    scientific    genetics    capacity    laboratory    establishing    achilles    rehabilitation    network    services    gene    consulting    centre    medical    regenerative    global    center    treatment    injuries    galway    kur    ireland    links    diseases    property    continue    science    developmental    national   

Project "Achilles" data sheet

The following table provides information about the project.


Organization address
address: LARGO DO PACO
city: BRAGA
postcode: 4704 553

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 999˙626 €
 EC max contribution 999˙626 € (100%)
 Programme 1. H2020-EU.4.b. (Twinning of research institutions)
 Code Call H2020-WIDESPREAD-05-2017-Twinning
 Funding Scheme CSA
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2021-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDADE DO MINHO PT (BRAGA) coordinator 500˙601.00
3    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) participant 249˙512.00


 Project objective

The main goal of Achilles is to significantly strengthen the science and technology capacity of UMinho in biophysics, cell/molecular biology and genetics/gene therapy in order to achieve global scientific excellence and competitiveness for the translation of advanced therapies/ tendon tissue engineering strategies to treat tendon injuries/diseases; At the same tine, Achilles also aims at positioning the research profile of UMinho and its staff in an outstanding international research level. This will be achieved by establishing a twinning process through knowledge sharing and collaboration between 3B’s Research Group of University of Minho (UMinho) and 3 internationally leading institutions: Department of Trauma Surgery of the University Regensburg Medical Centre (KUR), the Regenerative, Modular & Developmental Engineering Laboratory of the National University of Ireland Galway (NUIG) and the Rehabilitation Medicine Research Center of Mayo Clinic (MAYO). Achilles will focus in defined areas in which UMinho shows a less scientific knowledge and are well-complemented by KUR/NUIG/MAYO.
The project objectives are: - To significantly increase the scientific excellence in tendon tissue engineering and reinforce human resources profile of UMinho; - To significantly increase the international visibility of UMinho and unleash its networking gaps with international outstanding R&D organisations; - To create strong links between UMinho-KUR-NUIG-Mayo allowing a constant and sustained knowledge sharing and research collaboration network which will continue sustainably in the long-term; - To significantly increase the capacity of UMinho to translate excellent scientific production into new therapeutic approaches for the treatment of tendon disorders and in providing high-quality services and consulting, improved capability to compete for funding as well as generating useful intellectual property that can help to support in the long-term the sustainability of the organization.


year authors and title journal last update
List of publications.
2020 Prof. Dr. Denitsa Docheva (Guest Editor)
Special issue “Achilles Curse and Remedy: Tendon Diseases from Pathophysiology to Novel Therapeutic Approaches”
published pages: , ISSN: 1422-0067, DOI:
International Journal of Molecular Sciences 2020-04-15
2018 S. Ribeiro, V. Novacek, E.M. Fernandes, M.E. Gomes, R.L. Reis, Y. Bayon, D.I. Zeugolis
published pages: , ISSN: 2049-4416, DOI:
The Bone & Joint Journal/Orthopaedic Proceedings 2020-04-15
2019 Mari Carmen Echave, Rui M. A. Domingues, Manuel Gómez-Florit, José Luis Pedraz, Rui L. Reis, Gorka Orive, Manuela E. Gomes
Biphasic Hydrogels Integrating Mineralized and Anisotropic Features for Interfacial Tissue Engineering
published pages: 47771-47784, ISSN: 1944-8244, DOI: 10.1021/acsami.9b17826
ACS Applied Materials & Interfaces 11/51 2020-03-05
2019 Ana I. Gonçalves, Dominika Berdecka, Márcia T. Rodrigues, Aysegul Dede Eren, Jan Boer, Rui L. Reis, Manuela E. Gomes
Evaluation of tenogenic differentiation potential of selected subpopulations of human adipose‐derived stem cells
published pages: 2204-2217, ISSN: 1932-6254, DOI: 10.1002/term.2967
Journal of Tissue Engineering and Regenerative Medicine 13/12 2020-03-05
2019 Raquel Costa-Almeida, Isabel Calejo, Manuela E. Gomes
Mesenchymal Stem Cells Empowering Tendon Regenerative Therapies
published pages: 3002, ISSN: 1422-0067, DOI: 10.3390/ijms20123002
International Journal of Molecular Sciences 20/12 2020-03-05
2020 Ana M. Matos, Ana I. Gonçalves, Alicia J. El Haj, Manuela E. Gomes
Magnetic biomaterials and nano-instructive tools as mediators of tendon mechanotransduction
published pages: 140-148, ISSN: 2516-0230, DOI: 10.1039/c9na00615j
Nanoscale Advances 2/1 2020-03-05
2018 A.I. Gonçalves, P.M. Gershovich, M.T. Rodrigues, R.L. Reis, M.E. Gomes
Human adipose tissue-derived tenomodulin positive subpopulation of stem cells: A promising source of tendon progenitor cells
published pages: 762-774, ISSN: 1932-6254, DOI: 10.1002/term.2495
Journal of Tissue Engineering and Regenerative Medicine 12/3 2019-10-08
2017 Mariana Laranjeira, Rui M. A. Domingues, Raquel Costa-Almeida, Rui L. Reis, Manuela E. Gomes
3D Mimicry of Native-Tissue-Fiber Architecture Guides Tendon-Derived Cells and Adipose Stem Cells into Artificial Tendon Constructs
published pages: 1700689, ISSN: 1613-6810, DOI: 10.1002/smll.201700689
Small 13/31 2019-10-08
2017 Ana I. Gonçalves, Márcia T. Rodrigues, Manuela E. Gomes
Tissue-engineered magnetic cell sheet patches for advanced strategies in tendon regeneration
published pages: 110-122, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2017.09.014
Acta Biomaterialia 63 2019-10-08
2016 Ana I. Gonçalves, Márcia T. Rodrigues, Pedro P. Carvalho, Manuel Bañobre-López, Elvira Paz, Paulo Freitas, Manuela E. Gomes
Exploring the Potential of Starch/Polycaprolactone Aligned Magnetic Responsive Scaffolds for Tendon Regeneration
published pages: 213-222, ISSN: 2192-2640, DOI: 10.1002/adhm.201500623
Advanced Healthcare Materials 5/2 2019-10-08
2018 Raquel Costa-Almeida, Rui M.A. Domingues, Afsoon Fallahi, Huseyin Avci, Iman K. Yazdi, Mohsen Akbari, Rui L. Reis, Ali Tamayol, Manuela E. Gomes, Ali Khademhosseini
Cell-laden composite suture threads for repairing damaged tendons
published pages: 1039-1048, ISSN: 1932-6254, DOI: 10.1002/term.2605
Journal of Tissue Engineering and Regenerative Medicine 12/4 2019-10-08
2018 Elsa D. Silva, Pedro S. Babo, Raquel Costa-Almeida, Rui M.A. Domingues, Bárbara B. Mendes, Elvira Paz, Paulo Freitas, Márcia T. Rodrigues, Pedro L. Granja, Manuela E. Gomes
Multifunctional magnetic-responsive hydrogels to engineer tendon-to-bone interface
published pages: 2375-2385, ISSN: 1549-9634, DOI: 10.1016/j.nano.2017.06.002
Nanomedicine: Nanotechnology, Biology and Medicine 14/7 2019-10-08
2018 A.I. Gonçalves, M. Rotherham, H. Markides, M.T. Rodrigues, R.L. Reis, M.E. Gomes, A.J. El Haj
Triggering the activation of Activin A type II receptor in human adipose stem cells towards tenogenic commitment using mechanomagnetic stimulation
published pages: 1149-1159, ISSN: 1549-9634, DOI: 10.1016/j.nano.2018.02.008
Nanomedicine: Nanotechnology, Biology and Medicine 14/4 2019-10-08
2016 Lívia Santos, Marta Silva, Ana I. Gonçalves, Tamagno Pesqueira, Márcia T. Rodrigues, Manuela E. Gomes
In vitro and in vivo assessment of magnetically actuated biomaterials and prospects in tendon healing
published pages: 1107-1122, ISSN: 1743-5889, DOI: 10.2217/nnm-2015-0014
Nanomedicine 11/9 2019-10-08
2018 Raquel Costa-Almeida, Albina R. Franco, Tamagno Pesqueira, Mariana B. Oliveira, Pedro S. Babo, Isabel B. Leonor, João F. Mano, Rui L. Reis, Manuela E. Gomes
The effects of platelet lysate patches on the activity of tendon-derived cells
published pages: 29-40, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.01.006
Acta Biomaterialia 68 2019-10-08
2016 Rui M. A. Domingues, Silvia Chiera, Pavel Gershovich, Antonella Motta, Rui L. Reis, Manuela E. Gomes
Enhancing the Biomechanical Performance of Anisotropic Nanofibrous Scaffolds in Tendon Tissue Engineering: Reinforcement with Cellulose Nanocrystals
published pages: 1364-1375, ISSN: 2192-2640, DOI: 10.1002/adhm.201501048
Advanced Healthcare Materials 5/11 2019-10-08

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