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REMODEL SIGNED

Research models in infection, cancer and regeneration: replacement and translation

Total Cost €

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EC-Contrib. €

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Partnership

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Project "REMODEL" data sheet

The following table provides information about the project.

Coordinator
INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC 

Organization address
address: RUA ALFREDO ALLEN 208
city: PORTO
postcode: 4200 135
website: www.ibmc.up.pt

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 799˙647 €
 EC max contribution 799˙647 € (100%)
 Programme 1. H2020-EU.4.b. (Twinning of research institutions)
 Code Call H2020-WIDESPREAD-2018-03
 Funding Scheme CSA
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2022-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC PT (PORTO) coordinator 314˙771.00
2    UNIVERSITEIT UTRECHT NL (UTRECHT) participant 190˙250.00
3    JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG DE (WUERZBURG) participant 185˙251.00
4    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) participant 109˙375.00

Map

 Project objective

REMODEL combines the existing local expertise in bioengineering, cancer and infectious diseases with partners at the frontline in developing organoid systems, manipulating them to fit specific purposes and validating their use as models, in order to build capacity to work with innovative model systems that can replace animal experiments and increase translational relevance. In doing so, REMODEL addresses a key issue in today’s biomedical research: how non-animal model systems can be developed to meet the needs for translationally relevant research in the era of precision and personalized medicine, whilst at the same time accounting for societal pressure to replace animal experiments. REMODEL will capacitate the coordinating institution, IBMC-i3S, through the establishment of organoid advanced in vitro models and their customization for the main areas of research (infection, cancer and tissue regeneration). REMODEL will contribute to raising the research profile of the institution and scientific skills of its staff developed through training schools and short-term scientific training periods as well as transferable skills training and mentoring of Early Stage researchers, but also through staff participation in international conferences presenting work within the REMODEL themes / framework. Organoids as experimental models are at the frontline of methodological development in biomedicine, and demonstrating competence in working with such models will place i3S in the spotlight in an international research context, and make the institution an attractive partner for future collaborations beyond the REMODEL network. On the European level, REMODEL represents an important initiative to bring together key partners in the development of innovative models to overcome the present fragmentation of European organoid research and move towards applications in animal replacement.

 Publications

year authors and title journal last update
List of publications.
2017 Kaori L. Fonseca, Pedro N. S. Rodrigues, I. Anna S. Olsson, Margarida Saraiva
Experimental study of tuberculosis: From animal models to complex cell systems and organoids
published pages: e1006421, ISSN: 1553-7374, DOI: 10.1371/journal.ppat.1006421
PLOS Pathogens 13/8 2020-04-17
2019 Daniela Barros, Paula Parreira, Joana Furtado, Frederico Ferreira-da-Silva, Eduardo Conde-Sousa, Andrés J. García, M. Cristina L. Martins, Isabel Freitas Amaral, Ana Paula Pêgo
An affinity-based approach to engineer laminin-presenting cell instructive microenvironments
published pages: 601-611, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2018.10.039
Biomaterials 192 2020-04-17
2018 Meritxell Balmaña, Stefan Mereiter, Francisca Diniz, Tália Feijão, Cristina Barrias, Celso Reis
Multicellular Human Gastric Cancer Spheroids Mimic the Glycosylation Phenotype of Gastric Carcinomas
published pages: 2815, ISSN: 1420-3049, DOI: 10.3390/molecules23112815
Molecules 23/11 2020-04-17
2017 Joana Silva, Ana R. Bento, Daniela Barros, Tiago L. Laundos, Susana R. Sousa, Pedro Quelhas, Mónica M. Sousa, Ana P. Pêgo, Isabel F. Amaral
Fibrin functionalization with synthetic adhesive ligands interacting with α6β1 integrin receptor enhance neurite outgrowth of embryonic stem cell-derived neural stem/progenitors
published pages: 243-256, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2017.07.013
Acta Biomaterialia 59 2020-04-17

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The information about "REMODEL" are provided by the European Opendata Portal: CORDIS opendata.

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