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Pleiotropy and Evolutionary Constraint

Total Cost €


EC-Contrib. €






Project "PLEVOCON" data sheet

The following table provides information about the project.


Organization address
city: BERN
postcode: 3012

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Project website
 Total cost 187˙419 €
 EC max contribution 187˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2020-09-20


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET BERN CH (BERN) coordinator 187˙419.00


 Project objective

When organisms adapt to new environments, are the genetic mechanisms that underlie evolutionary trajectories predictable or stochastic? Recently, genomic studies have provided tantalizing clues that the genetic mechanisms that underlie evolutionary trajectories may be more constrained and deterministic than previously thought. Theoretical work has suggested that pleiotropy, or the influence of a single gene on multiple traits, might be an important deterministic factor during adaptive evolution. Specifically, high levels of pleiotropy are predicted to decrease the frequency with which a locus is used over the course of evolution because it is much more likely that mutations in that locus will have negative fitness consequences. Despite these theoretical predictions, however, we lack explicit tests of how pleiotropy contributes to evolutionary predictability. The objective of the PLEVOCON project is to test whether pleiotropy is a source of evolutionary constraint that underlies the predictability of evolutionary responses. The threespine stickleback (Gasterosteus aculeatus) is an ideal system in which to test whether pleiotropy is a source of evolutionary constraint. Crucially, these small fish have independently and repeatedly adapted to diverse freshwater habitats in the northern hemisphere since the retreat of the glaciers 12,000 years ago. Stickleback living in similar habitats have evolved similar phenotypes, providing an opportunity to ask whether the same genes underlie adaptation to these habitats, and whether genes that are repeatedly used for adaptation have lower levels of pleiotropy. I will utilize the existing wealth of genetic and genomic resources in this system and develop innovative statistical approaches to carry out the first genome-wide test of whether pleiotropy is a source of constraint in evolutionary responses.


year authors and title journal last update
List of publications.
2019 Diana J. Rennison, Yoel E. Stuart, Daniel I. Bolnick, Catherine L. Peichel
Ecological factors and morphological traits are associated with repeated genomic differentiation between lake and stream stickleback
published pages: 20180241, ISSN: 0962-8436, DOI: 10.1098/rstb.2018.0241
Philosophical Transactions of the Royal Society B: Biological Sciences 374/1777 2020-01-14
2019 Diana Jessie Rennison, Kira E. Delmore, Kieran Samuk, Gregory L. Owens, Sara E. Miller
Shared patterns of genome-wide differentiation are more strongly predicted by geography than by ecology
published pages: , ISSN: 0003-0147, DOI: 10.1086/706476
The American Naturalist 2020-01-14

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