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DN-CARTILOGEL

Design of double network polycarbonate-based hydrogels by simultaneous reactions: scaffolds for load-bearing soft tissue regeneration

Total Cost €

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EC-Contrib. €

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Partnership

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Project "DN-CARTILOGEL" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF BIRMINGHAM 

Organization address
address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT
website: www.bham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://mmpmresearch.myfreesites.net/
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-09-12   to  2018-09-11

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) coordinator 41˙022.00
2    THE UNIVERSITY OF WARWICK UK (COVENTRY) participant 142˙432.00

Map

 Project objective

Polymer materials have outstanding properties with which to be applied for a wide range of applications. In particular, hydrogel materials are widely studied for applications in tissue engineering on account of their high water contents. Despite the advances in these materials, some biomedical targets remain challenging. Articular cartilage (AC) is the white flexible load-bearing soft tissue able to withstand the highest loads in physically demanding areas of the body. Once it is damaged, its poor ability for self-repair may induce a progressive loss of function that, ultimately, results in a severe musculoskeletal degenerative condition. While most commonly used hydrogel fabrication techniques still have practical limitations or do not lead to materials that are sufficiently strong for AC regeneration, the DN-Cartilogel project proposes the preparation of innovative tough, double network hydrogel materials that are based on advanced hydrophilic poly(carbonate)s. The tailored design of polymers with specific side-chain and end group functionalities will lead to hydrogel materials with improved mechanical strength, toughness and high water content. To this end, the project will apply the one-step synthetic methodology based on orthogonal click chemistry that was reported recently by the host group to generate novel and highly tunable materials. The ultimate goal is to develop a straightforward path to design robust DN hydrogels able to induce the differentiation of mesenchymal stem cells into specialized cartilage-producing cells, which directly addresses priorities established by the H2020 Work Programme.

 Publications

year authors and title journal last update
List of publications.
2018 Laura J. Macdougall, Maria M. Pérez-Madrigal, Joshua E. Shaw, Maria Inam, Judith A. Hoyland, Rachel O\'Reilly, Stephen M. Richardson, Andrew P. Dove
Self-healing, stretchable and robust interpenetrating network hydrogels
published pages: , ISSN: 2047-4830, DOI: 10.1039/C8BM00872H
Biomaterials Science 2019-05-13
2017 Anthony W. Thomas, Paula K. Kuroishi, Maria M. Pérez-Madrigal, Andrew K. Whittaker, Andrew P. Dove
Synthesis of aliphatic polycarbonates with a tuneable thermal response
published pages: 5082-5090, ISSN: 1759-9954, DOI: 10.1039/C7PY00358G
Polymer Chemistry 8/34 2019-06-13
2017 Laura J. Macdougall, Maria M. Pérez-Madrigal, Maria C. Arno, Andrew P. Dove
Nonswelling Thiol–Yne Cross-Linked Hydrogel Materials as Cytocompatible Soft Tissue Scaffolds
published pages: , ISSN: 1525-7797, DOI: 10.1021/acs.biomac.7b01204
Biomacromolecules 2019-06-13

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The information about "DN-CARTILOGEL" are provided by the European Opendata Portal: CORDIS opendata.

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