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FlyGutHomeostasis SIGNED

Identification of paracrine and systemic signals controlling adult stem cell activity and organ homeostasis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 FlyGutHomeostasis project word cloud

Explore the words cloud of the FlyGutHomeostasis project. It provides you a very rough idea of what is the project "FlyGutHomeostasis" about.

enteroendocrine    behavior    molecular    systematic    proliferative    activation    fly    feeding    enterocytes    deciphering    isc    vms    encoding    flies    disease    energy    function    tnfr    challenged    communication    vertebrate    homeostasis    organ    ee    local    stem    muscles    prime    division    despite    potentially    inputs    insects    due    circuitries    systemic    genes    ageing    multiple    enteroblasts    couple    capacity    inter    ebs    coupled    organismal    balance    renewal    reveal    organs    physiology    steady    feasible    screens    couplings    suited    gut    mammals    rnais    signals    intestinal    final    paradigm    turnover    model    tissue    divergence    coupling    peptides    epithelial    fitness    remarkable    nutrient    environmental    physiological    adult    health    relays    models    saturating    knockdown    cells    infection    niche    cell    shown    ligand    renewing    ees    pathological    proteins    independent    proliferation    self    membrane    tightly    gi    gastrointestinal    mammalian    ecs    transmembrane    metabolism    released    stress    visceral    secreted   

Project "FlyGutHomeostasis" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 1˙498˙964 €
 EC max contribution 1˙498˙964 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2024-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 1˙498˙964.00

Map

 Project objective

Due to its remarkable self-renewing capacity, the fly gut has recently become a prime paradigm for studying stem-cell function during adult tissue homeostasis. This capacity for self-renewal relays on the proliferative activity of the intestinal stem cells (ISC), which is tightly coupled with cell loss to maintain intestinal homeostasis. ISC proliferation is controlled by multiple local and systemic signals released from the ISC niche (enterocytes (ECs), enteroendocrine (EE) cells, enteroblasts (EBs), and visceral muscles (VMs)) and non-gastrointestinal (non-GI) organs. Despite the physiological divergence between insects and mammals, studies have shown that flies represent a model that is well suited for studying stem cell physiology during ageing, stress, and infection. As a saturating approach to identify local and systemic signals controlling intestinal homeostasis in steady-state and challenged conditions, RNAis will be used to known down all genes encoding secreted peptides specifically in ECs, EEs, or VMs and all genes encoding transmembrane and membrane-associated proteins in the VMs. The proposed screens should identify novel intra- and inter-organ circuitries allowing communication between the gut and other organs to provide organismal health. In addition, the systematic knockdown of secreted peptides from the ISC niche could identify gut-derived signals that couple changes in environmental inputs, such as nutrient availability, with systemic changes in feeding behavior, energy balance, and metabolism. Since large-scale approaches are not feasible in vertebrate models, the signals identified in the above screens could potentially reveal novel couplings contributing to mammalian GI homeostasis and disease. The final part of the proposed project aims a deciphering the molecular signals coupling epithelial fitness with ligand-independent TNFR activation to control ISC division and epithelial turnover in steady-state, challenged and pathological conditions.

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The information about "FLYGUTHOMEOSTASIS" are provided by the European Opendata Portal: CORDIS opendata.

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