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DYNACEUTICS SIGNED

Remote control healing: Next generation mechano-nano-therapeutics

Total Cost €

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EC-Contrib. €

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Partnership

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Project "DYNACEUTICS" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF BIRMINGHAM 

Organization address
address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT
website: www.bham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙499˙068 €
 EC max contribution 2˙499˙068 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) coordinator 2˙499˙068.00

Map

 Project objective

Imagine if doctors could heal patients via remote control. Following simple injections into regions of the body, they could activate internal cells by an external bandage. In this way, they could remotely control the ways tissue heal. This Advanced grant sets out to understand, design and develop the mechano-nano-magnetic platform that will underpin this therapeutic strategy for the future – DYNACEUTICS. Key receptors have been identified such as ion channels, integrins and growth factors which respond to mechanical cues on the membrane and activate downstream pathways. How do we ‘bottle’ an agonist like a drug which can influence or regulate mechano-sensors on the membrane and can be controlled remotely? This project tackles this complex interdisciplinary question through breakthrough nanotechnologies. We aim to expand and develop a platform technology using magnetic particle tagging which will allow us to direct cells for therapeutic purposes. Specifically, we aim • to identify mechano-receptor binding sites on stem and mature cells which will enable remote activation of signalling pathways via magnetic fields, • to design and test magnetic particles with tailored tagging strategies using single cell through 3D human organoid models to in vivo disease models, • to tailor and design external remote control devices • to create clinically relevant treatment modalities for remote control healing. This proposal presents a unique opportunity to launch a new dynamic treatment platform, DYNACEUTICS, which we propose will extend the therapeutic horizon and provide a new form of remote controlled healing.

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The information about "DYNACEUTICS" are provided by the European Opendata Portal: CORDIS opendata.

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