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LIGHTPORT SIGNED

From light-stimulated anion receptors to transmembrane carriers and pumps

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 LIGHTPORT project word cloud

Explore the words cloud of the LIGHTPORT project. It provides you a very rough idea of what is the project "LIGHTPORT" about.

channel    concentration    cell    integrate    directed    environment    utilizing    pharmacological    stimuli    dynamically    last    photoswitchable    anion    active    transport    wp2    bilayers    constructing    chemists    pumping    diseases    treatment    static    structures    divided    bacterial    deals    endeavour    triggered    completely    synthetic    induce    mediated    whereas    convert    light    platforms    progress    natural    receptors    structurally    packages    gated    biological    anions    prepared    transporters    gradients    despite    binding    energy    dual    visible    pumps    function    membranes    solar    cancer    behavior    store    responsive    contemporary    membrane    alternative    proteins    decade    mechanically    hosts    interdisciplinary    anionic    rigid    phospholipid    dysregulation    transmembrane    carriers    localized    actuated    interlocked    regulate    modulated    wp1    death    gradient    mimic    view    wp3    mostly    artificial    photoswitches    toward    passive    route   

Project "LIGHTPORT" data sheet

The following table provides information about the project.

Coordinator
RIJKSUNIVERSITEIT GRONINGEN 

Organization address
address: Broerstraat 5
city: GRONINGEN
postcode: 9712CP
website: www.rug.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙499˙461 €
 EC max contribution 1˙499˙461 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2024-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    RIJKSUNIVERSITEIT GRONINGEN NL (GRONINGEN) coordinator 1˙499˙461.00

Map

 Project objective

The transport of anions across the cell membrane, which is mediated by transport proteins, is essential to many important biological processes. Dysregulation of this transport has been associated to various diseases and therefore, chemists endeavour to develop artificial receptors that mimic the function of natural transporters. Despite much progress over the last decade, the current artificial systems are mostly static, while proteins are able to change their activity dynamically in response to stimuli in the environment. To integrate such stimuli-controlled behavior in synthetic systems is a key contemporary challenge. In view of this, the goal of the proposed research program is to develop anion receptors in which the binding properties can be effectively modulated by light and to apply these receptors as transmembrane carriers and pumps, in order to regulate passive transport (i.e. down a concentration gradient) and to induce active transport (i.e. against a concentration gradient). This interdisciplinary program is divided into three work packages: WP1 aims at the development of structurally rigid and visible-light-actuated photoswitches and their use as platforms for constructing anion receptors; WP2 deals with the development of mechanically interlocked structures as photoswitchable anionic hosts; WP3 is directed at utilizing these receptors for light-gated transport and light-driven pumping of anions across phospholipid bilayers, whereas also an alternative dual-responsive anion channel will be prepared. Eventually, it is expected that this work will open a new route toward light-based localized pharmacological treatment, e.g. via light-triggered cancer or bacterial cell death. Furthermore, active transport systems, that are able to build up and maintain concentration gradients across membranes, could provide a completely new view on how to convert and store light (solar) energy.

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The information about "LIGHTPORT" are provided by the European Opendata Portal: CORDIS opendata.

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