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LIGHTPORT SIGNED

From light-stimulated anion receptors to transmembrane carriers and pumps

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 LIGHTPORT project word cloud

Explore the words cloud of the LIGHTPORT project. It provides you a very rough idea of what is the project "LIGHTPORT" about.

view    channel    passive    dual    chemists    gated    natural    progress    receptors    completely    directed    cancer    mediated    prepared    energy    mostly    bacterial    stimuli    mimic    wp1    synthetic    transporters    binding    constructing    structurally    convert    proteins    localized    interdisciplinary    gradient    route    behavior    biological    deals    photoswitches    diseases    anion    bilayers    structures    triggered    light    anionic    treatment    toward    function    actuated    pumping    store    gradients    wp3    active    responsive    photoswitchable    dynamically    dysregulation    integrate    whereas    decade    carriers    concentration    induce    despite    mechanically    static    packages    hosts    endeavour    platforms    anions    modulated    last    transport    environment    regulate    membrane    interlocked    artificial    solar    phospholipid    membranes    death    pumps    visible    wp2    rigid    cell    alternative    pharmacological    transmembrane    divided    utilizing    contemporary   

Project "LIGHTPORT" data sheet

The following table provides information about the project.

Coordinator
RIJKSUNIVERSITEIT GRONINGEN 

Organization address
address: Broerstraat 5
city: GRONINGEN
postcode: 9712CP
website: www.rug.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙499˙461 €
 EC max contribution 1˙499˙461 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-03-01   to  2024-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    RIJKSUNIVERSITEIT GRONINGEN NL (GRONINGEN) coordinator 1˙499˙461.00

Map

 Project objective

The transport of anions across the cell membrane, which is mediated by transport proteins, is essential to many important biological processes. Dysregulation of this transport has been associated to various diseases and therefore, chemists endeavour to develop artificial receptors that mimic the function of natural transporters. Despite much progress over the last decade, the current artificial systems are mostly static, while proteins are able to change their activity dynamically in response to stimuli in the environment. To integrate such stimuli-controlled behavior in synthetic systems is a key contemporary challenge. In view of this, the goal of the proposed research program is to develop anion receptors in which the binding properties can be effectively modulated by light and to apply these receptors as transmembrane carriers and pumps, in order to regulate passive transport (i.e. down a concentration gradient) and to induce active transport (i.e. against a concentration gradient). This interdisciplinary program is divided into three work packages: WP1 aims at the development of structurally rigid and visible-light-actuated photoswitches and their use as platforms for constructing anion receptors; WP2 deals with the development of mechanically interlocked structures as photoswitchable anionic hosts; WP3 is directed at utilizing these receptors for light-gated transport and light-driven pumping of anions across phospholipid bilayers, whereas also an alternative dual-responsive anion channel will be prepared. Eventually, it is expected that this work will open a new route toward light-based localized pharmacological treatment, e.g. via light-triggered cancer or bacterial cell death. Furthermore, active transport systems, that are able to build up and maintain concentration gradients across membranes, could provide a completely new view on how to convert and store light (solar) energy.

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The information about "LIGHTPORT" are provided by the European Opendata Portal: CORDIS opendata.

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