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MNSWLGM SIGNED

An optofluidic platform based on liquid-gradient refractive index microlens for the isolation and quantification of extracellular vesicles

Total Cost €

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EC-Contrib. €

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Partnership

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Project "MNSWLGM" data sheet

The following table provides information about the project.

Coordinator
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 187˙419 €
 EC max contribution 187˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 187˙419.00

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 Project objective

Extracellular vesicles (EVs) describe distinct populations of small (30-200 nm) and large (500 nm-2 μm) microvesicles actively or passively secreted by cells. Whilst, they are recognized as promising biomarkers for diseases diagnosis, prognosis and therapy, their purification, selective enrichment, and characterization remains immensely challenging. The goal of the current proposal is to develop an optofluidic platform able to manipulate and characterize single EVs and facilitate their efficient purification and quantitation from biological samples. The optofluidic platform will incorporate a dynamically reconfigurable optical lattice (constructed from a liquid gradient refractive index - L-GRIN microlens) for separation followed by a viscoelastic focusing module for single EV imaging. The strength of the interaction between a nanoparticle and the optical lattice will depend on the optical polarizability of the particle, thus providing a size selection criterion to allow identification and isolation. Put simply, we aim to develop a size-selective optofluidic platform integrated for non-invasive EVs sorting and fractionation that can be applied to a wide range of biological matrices and addresses the most challenging technological bottleneck in EVs research.

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The information about "MNSWLGM" are provided by the European Opendata Portal: CORDIS opendata.

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