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FURTHER SIGNED

Focused Ultrasound and RadioTHERapy for Noninvasive Palliative Pain Treatment in Patients with Bone Metastasis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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Project "FURTHER" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAIR MEDISCH CENTRUM UTRECHT 

Organization address
address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX
website: www.umcutrecht.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 4˙018˙187 €
 EC max contribution 3˙998˙125 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SC1-2018-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2019
 Duration (year-month-day) from 2019-01-01   to  2023-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) coordinator 971˙312.00
2    THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL UK (LONDON) participant 756˙192.00
3    KLINIKUM DER UNIVERSITAET ZU KOELN DE (KOELN) participant 646˙415.00
4    VARSINAIS-SUOMEN SAIRAANHOITOPIIRIN KUNTAYHTYMA FI (TURKU) participant 430˙250.00
5    STICHTING ISALA KLINIEKEN NL (ZWOLLE) participant 386˙250.00
6    ISTITUTO ORTOPEDICO RIZZOLI IT (BOLOGNA) participant 280˙835.00
7    CENTRO SA.NA. SERVIZI SANITARI PRIVATI SRL IT (APRILIA) participant 260˙625.00
8    UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA IT (ROMA) participant 158˙750.00
9    ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA IT (BOLOGNA) participant 107˙495.00
10    FOCUSED ULTRASOUND FOUNDATION US (CHARLOTTESVILLE) participant 0.00

Map

 Project objective

Bone metastases are a common manifestation of advanced cancer, with pain as a devastating consequence. Due to rising cancer incidence rates and improving survival, the number of cancer patients living long enough to develop bone metastases is increasing rapidly. Metastatic bone pain is difficult to manage and has a detrimental impact on quality of life of patients, their partners and care-givers.

Radiation therapy (RT), the standard treatment for palliation of metastatic bone pain, is easy to administer and well tolerated. However, RT is only effective in 60-70% of patients and usually takes four weeks before inducing pain response. Inadequate pain relief is therefore common and alternative treatment options are urgently needed.

Pain palliation may be substantially improved by including MR-HIFU as alternative or in addition to RT. Preliminary studies suggest that MR-HIFU induces rapid pain relief (within days), and may palliate pain in patients in whom RT is not effective. Currently, strong evidence and context is lacking for wide-spread implementation of MR-HIFU into routine care.

The FURTHER project aims to demonstrate (cost)effectiveness of MR-HIFU as an alternative or additional treatment option to relief metastatic bone pain. For this purpose, a three arm international randomized controlled trial (RCT) including 216 patients will be conducted comparing early and late pain response in patients treated with RT only, MR-HIFU only, and RT with MR-HIFU. A prediction model will be developed to identify patients who are likely to benefit from MR-HIFU in order to allow (cost-) effective use of the treatment. A pilot pathway RCT will be conducted to explore the effectiveness of MR-HIFU as part of a comprehensive pain management strategy. Finally, FURTHER will map and analyse socio-economic barriers for integration of MR-HIFU in routine care in the wider European context and make recommendations on how to provide equal access to this promising new treatment.

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The information about "FURTHER" are provided by the European Opendata Portal: CORDIS opendata.

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