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The MATRIX SIGNED

Inflammatory resolution and remodelling of the adipose extracellular matrix: key determinants of a metabolically healthy phenotype?

Total Cost €

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EC-Contrib. €

0

Partnership

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 The MATRIX project word cloud

Explore the words cloud of the The MATRIX project. It provides you a very rough idea of what is the project "The MATRIX" about.

ex    mho    phenotypes    disease    combines    unhealthy    cells    endogenous    muo    driver    adipose    protected    coupled    cell    reduce    healthy    pro    resolve    inflammation    extracellular    vivo    distinguishes    urgently    resolving    trials    burden    subgroups    inflammatory    drug    protein    translational    differentiate    understand    limited    techniques    fingerprints    health    individuals    clinical    molecular    specialised    bioinformatics    that    obesity    hypothesise    patient    comorbidities    anti    human    metabolically    followed    lab    cutting    consists    matrix    certain    socio    disciplinary    triggers    respective    appear    attempting    groups    edge    economic    biobanks    preliminary    switch    placement    separates    right    me    drugs    affiliated    halt    obese    biology    lipid    pipelines    diseases    ultimately    data    regulated    lipids    tackle    serious    pose    lean    site    candidate    mhl    remodelling    public    appears    metabolic    mul    generate    metabolite    critical    diabetes    therapeutic    lines   

Project "The MATRIX" data sheet

The following table provides information about the project.

Coordinator
GOETEBORGS UNIVERSITET 

Organization address
address: VASAPARKEN
city: GOETEBORG
postcode: 405 30
website: www.gu.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 1˙700˙002 €
 EC max contribution 1˙700˙002 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2024-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    GOETEBORGS UNIVERSITET SE (GOETEBORG) coordinator 1˙700˙002.00

Map

 Project objective

Obesity and its affiliated metabolic diseases pose serious public-health challenges. However, certain patient subgroups appear protected. To halt the socio-economic burden of metabolic disease, we urgently need to understand what distinguishes the Metabolically-Healthy-Lean (MHL), Metabolically-Unhealthy-Lean (MUL), Metabolically-Healthy-Obese (MHO) and Metabolically-Unhealthy-Obese (MUO) phenotypes, and which factors promote metabolic health. Inflammation has been proposed as a target, as it is a key driver of metabolic disease. However, clinical trials show limited evidence that anti-inflammatory drugs reduce diabetes. Why is that?

Inflammation consists of a pro-inflammatory phase followed by a pro-resolving phase, which are regulated by different cells/pathways. This is critical to consider when attempting a therapeutic approach. Based on my preliminary data, I hypothesise that what separates MHL/MHO from MUL/MUO are not pro-inflammatory triggers, but rather the endogenous ability of individuals to resolve inflammation. Adipose extracellular-matrix remodelling appears critical, and pro-resolving lipids promote a MUO-to-MHO switch.

My overall goal is to determine molecular pathways that differentiate the MHL/MUL/MHO/MUO phenotypes (Aim 1-4), and to investigate the therapeutic potential of pro-resolving lipids (Aim 5). This multi-disciplinary project combines cutting-edge techniques with state-of-the-art translational approaches. Through my unique access to human biobanks, I will generate patient-specific cell-lines and test drug-targets ex vivo. Novel bioinformatics pipelines will produce protein/lipid/metabolite fingerprints associated with respective patient groups, ultimately providing a new approach to tackle obesity-related comorbidities. My experience in the specialised field of pro-resolving lipid biology, coupled with my lab’s unique placement at a translational site, makes me the right candidate to lead this research program.

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The information about "THE MATRIX" are provided by the European Opendata Portal: CORDIS opendata.

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