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The MATRIX SIGNED

Inflammatory resolution and remodelling of the adipose extracellular matrix: key determinants of a metabolically healthy phenotype?

Total Cost €

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EC-Contrib. €

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Partnership

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 The MATRIX project word cloud

Explore the words cloud of the The MATRIX project. It provides you a very rough idea of what is the project "The MATRIX" about.

separates    economic    switch    bioinformatics    translational    tackle    inflammatory    cutting    driver    site    right    comorbidities    clinical    halt    generate    diabetes    critical    understand    preliminary    certain    edge    metabolically    cell    burden    ex    subgroups    followed    lipid    diseases    attempting    obesity    hypothesise    biology    individuals    obese    reduce    mhl    matrix    healthy    ultimately    regulated    pose    appear    therapeutic    unhealthy    specialised    fingerprints    groups    human    lean    triggers    protected    data    trials    limited    socio    patient    disciplinary    inflammation    mul    endogenous    respective    disease    anti    appears    muo    molecular    lines    lab    urgently    candidate    affiliated    extracellular    differentiate    resolving    health    drug    placement    lipids    serious    distinguishes    adipose    metabolite    combines    vivo    that    public    consists    coupled    metabolic    resolve    biobanks    drugs    remodelling    protein    pipelines    phenotypes    pro    cells    techniques    mho    me   

Project "The MATRIX" data sheet

The following table provides information about the project.

Coordinator		 GOETEBORGS UNIVERSITET 

Organization address
address: VASAPARKEN
city: GOETEBORG
postcode: 405 30
website: www.gu.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Sweden [SE]
 Total cost 1˙700˙002 €
 EC max contribution 1˙700˙002 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2024-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    GOETEBORGS UNIVERSITET SE (GOETEBORG) coordinator 1˙700˙002.00

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 Project objective

Obesity and its affiliated metabolic diseases pose serious public-health challenges. However, certain patient subgroups appear protected. To halt the socio-economic burden of metabolic disease, we urgently need to understand what distinguishes the Metabolically-Healthy-Lean (MHL), Metabolically-Unhealthy-Lean (MUL), Metabolically-Healthy-Obese (MHO) and Metabolically-Unhealthy-Obese (MUO) phenotypes, and which factors promote metabolic health. Inflammation has been proposed as a target, as it is a key driver of metabolic disease. However, clinical trials show limited evidence that anti-inflammatory drugs reduce diabetes. Why is that?

Inflammation consists of a pro-inflammatory phase followed by a pro-resolving phase, which are regulated by different cells/pathways. This is critical to consider when attempting a therapeutic approach. Based on my preliminary data, I hypothesise that what separates MHL/MHO from MUL/MUO are not pro-inflammatory triggers, but rather the endogenous ability of individuals to resolve inflammation. Adipose extracellular-matrix remodelling appears critical, and pro-resolving lipids promote a MUO-to-MHO switch.

My overall goal is to determine molecular pathways that differentiate the MHL/MUL/MHO/MUO phenotypes (Aim 1-4), and to investigate the therapeutic potential of pro-resolving lipids (Aim 5). This multi-disciplinary project combines cutting-edge techniques with state-of-the-art translational approaches. Through my unique access to human biobanks, I will generate patient-specific cell-lines and test drug-targets ex vivo. Novel bioinformatics pipelines will produce protein/lipid/metabolite fingerprints associated with respective patient groups, ultimately providing a new approach to tackle obesity-related comorbidities. My experience in the specialised field of pro-resolving lipid biology, coupled with my lab’s unique placement at a translational site, makes me the right candidate to lead this research program.

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The information about "THE MATRIX" are provided by the European Opendata Portal: CORDIS opendata.

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