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RespMicroFlows SIGNED

Unravelling respiratory microflows in silico and in vitro: novel paths for targeted pulmonary delivery in infants and young children

Total Cost €

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EC-Contrib. €

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Partnership

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 RespMicroFlows project word cloud

Explore the words cloud of the RespMicroFlows project. It provides you a very rough idea of what is the project "RespMicroFlows" about.

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Project "RespMicroFlows" data sheet

The following table provides information about the project.

Coordinator
TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY 

Organization address
address: SENATE BUILDING TECHNION CITY
city: HAIFA
postcode: 32000
website: www.technion.ac.il

contact info
title: n.a.
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surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country Israel [IL]
 Project website http://biofluids.technion.ac.il/erc/
 Total cost 1˙937˙500 €
 EC max contribution 1˙937˙500 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-06-01   to  2021-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY IL (HAIFA) coordinator 1˙937˙500.00

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 Project objective

Fundamental research on respiratory transport phenomena, quantifying momentum and mass transfer in the lung depths, is overwhelmingly focused on adults. Yet, children are not just miniature adults; their distinct lung structures and heterogeneous ventilation patterns set them aside from their parents. In RespMicroFlows, we will break this cycle and unravel the complex microflows characterizing alveolar airflows in the developing pulmonary acini. Our discoveries will foster ground-breaking transport strategies to tackle two urgent clinical needs that burden infants and young children. The first challenge relates to radically enhancing the delivery and deposition of therapeutics using inhalation aerosols; the second involves targeting liquid bolus installations in deep airways for surfactant replacement therapy.

By developing advanced in silico numerical simulations together with microfluidic in vitro platforms mimicking the pulmonary acinar environment, our efforts will not only deliver a gateway to reliably assess the outcomes of inhaling aerosols and predict deposition patterns in young populations, we will furthermore unravel the fundamentals of liquid bolus transport to achieve optimal surfactant delivery strategies in premature neonates. By recreating cellular alveolar environments that capture underlying physiological functions, our advanced acinus-on-chips will deliver both at true scale and in real time the first robust and reliable in vitro screening platforms of exogenous therapeutic materials in the context of inhaled aerosols and surfactant-laden installations. Combining advanced engineering-driven flow visualization solutions with strong foundations in transport phenomena, fluid dynamics and respiratory physiology, RespMicroFlows will pave the way to a new and unprecedented level in our understanding and quantitative mapping of respiratory flow phenomena and act as catalyst for novel targeted pulmonary drug delivery strategies in young children.

 Publications

year authors and title journal last update
List of publications.
2016 Philipp Hofemeier, Josué Sznitman
The role of anisotropic expansion for pulmonary acinar aerosol deposition
published pages: 3543-3548, ISSN: 0021-9290, DOI: 10.1016/j.jbiomech.2016.08.025
Journal of Biomechanics 49/14 2019-06-19
2017 Philipp Hofemeier, Kenishiro Koshiyama, Shigeo Wada, Josué Sznitman
One (sub-)acinus for all: Fate of inhaled aerosols in heterogeneous pulmonary acinar structures
published pages: 53-63, ISSN: 0928-0987, DOI: 10.1016/j.ejps.2017.09.033
European Journal of Pharmaceutical Sciences 113 2019-06-19
2017 Hagit Stauber, Dan Waisman, Netanel Korin, Josué Sznitman
Red blood cell dynamics in biomimetic microfluidic networks of pulmonary alveolar capillaries
published pages: 14103, ISSN: 1932-1058, DOI: 10.1063/1.4973930
Biomicrofluidics 11/1 2019-06-19
2017 Rami Fishler, Yan Ostrovski, Chao-Yi Lu, Josué Sznitman
Streamline crossing: An essential mechanism for aerosol dispersion in the pulmonary acinus
published pages: 222-227, ISSN: 0021-9290, DOI: 10.1016/j.jbiomech.2016.11.043
Journal of Biomechanics 50 2019-06-19
2017 Katrin Bauer, Eliram Nof, Josué Sznitman
Revisiting high-frequency oscillatory ventilation in vitro and in silico in neonatal conductive airway
published pages: , ISSN: 0268-0033, DOI: 10.1016/j.clinbiomech.2017.11.009
Clinical Biomechanics 2019-06-19
2017 Rami Fishler and Josue Sznitman
Novel aerodynamic sizing method using image-based analysis of settling velocities
published pages: 21-25, ISSN: , DOI:
Inhalation 11 2019-06-19
2017 Lihi Shachar-Berman, Yan Ostrovski, Alessandro De Rosis, Stavros Kassinos, Josué Sznitman
Transport of ellipsoid fibers in oscillatory shear flows: Implications for aerosol deposition in deep airways
published pages: 145-151, ISSN: 0928-0987, DOI: 10.1016/j.ejps.2017.09.023
European Journal of Pharmaceutical Sciences 113 2019-06-19
2016 Josué Sznitman, Ostrovski, Philipp Hofemeier
Augmenting regional and targeted delivery in the pulmonary acinus using magnetic particles
published pages: 3385-3395, ISSN: 1178-2013, DOI: 10.2147/IJN.S102138
International Journal of Nanomedicine Volume 11 2019-06-19
2018 Yan Ostrovski, Simon Dorfman, Maksim Mezhericher, Stavros Kassinos, Josué Sznitman
Targeted Drug Delivery to Upper Airways Using a Pulsed Aerosol Bolus and Inhaled Volume Tracking Method
published pages: , ISSN: 1386-6184, DOI: 10.1007/s10494-018-9927-1
Flow, Turbulence and Combustion 2019-05-27
2018 Janna Tenenbaum-Katan, Arbel Artzy-Schnirman, Rami Fishler, Netanel Korin, Josué Sznitman
Biomimetics of the pulmonary environment in vitro : A microfluidics perspective
published pages: 42209, ISSN: 1932-1058, DOI: 10.1063/1.5023034
Biomicrofluidics 12/4 2019-05-27
2018 Prashant Das, Eliram Nof, Israel Amirav, Stavros C. Kassinos, Josué Sznitman
Targeting inhaled aerosol delivery to upper airways in children: Insight from computational fluid dynamics (CFD)
published pages: e0207711, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0207711
PLOS ONE 13/11 2019-05-04

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