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ArpComplexity SIGNED

Defining the role of Arp2/3 complex diversity at multiple scales of biology

Total Cost €

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EC-Contrib. €

0

Partnership

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 ArpComplexity project word cloud

Explore the words cloud of the ArpComplexity project. It provides you a very rough idea of what is the project "ArpComplexity" about.

modified    humans    consisting    subunit    plan    powerful    family    seven    cells    composition    perform    muscle    lab    branched    model    imaging    members    cellular    encoded    critical    gomes    protein    individual    physiology    strengths    diversification    mice    multiple    stability    transgenic    functional    developmental    fluorescence    subunits    molecule    reagents    microscopy    genetically    stimulate    vitro    scales    reveal    complexity    labs    basis    physiological    purified    influence    live    takes    tomography    myofibers    risk    isoform    complexes    cultured    cell    structural    arp2    human    function    cryoelectron    dramatically    dependence    networks    diversity    shown    contributes    always    variations    biology    contribution    structure    electron    sustainability    eight    dynamic    interdisciplinary    cytoskeleton    single    operation    isoforms    quantitative    advantage    molecular    cryo    entity    mammals    synergistic    gain    builds    biological    array    actin    body    expressing    hierarchies   

Project "ArpComplexity" data sheet

The following table provides information about the project.

Coordinator
THE FRANCIS CRICK INSTITUTE LIMITED 

Organization address
address: 1 MIDLAND ROAD
city: LONDON
postcode: NW1 1AT
website: www.crick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 10˙715˙153 €
 EC max contribution 10˙715˙153 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-SyG
 Funding Scheme ERC-SyG
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2025-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE FRANCIS CRICK INSTITUTE LIMITED UK (LONDON) coordinator 4˙148˙087.00
2    BIRKBECK COLLEGE - UNIVERSITY OF LONDON UK (LONDON) participant 3˙359˙131.00
3    INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES PT (LISBOA) participant 3˙207˙935.00

Map

 Project objective

The actin cytoskeleton of the cell is critical for the complex, integrated processes associated with development, operation and sustainability of the human body. The Arp2/3 complex consisting of seven protein subunits is essential to stimulate dynamic branched actin networks needed for multiple cellular processes. The Arp2/3 complex has always been considered as a single entity, but in humans and other mammals, three of the Arp2/3 complex subunits are encoded by two isoforms, thus allowing the formation of eight distinct Arp2/3 complexes. The Way lab has shown that Arp2/3 subunit composition dramatically affects the formation and stability of branched actin networks. The Way and Gomes labs have shown how specific Arp2/3 isoforms are essential for muscle development.

Our synergistic, high-risk, high-gain goal is to define the role of Arp2/3 complex diversity at three hierarchies of biology:

1. Molecular basis of Arp2/3 diversification With purified isoform-specific complexes we will perform cryo-electron microscopy and single molecule fluorescence microscopy to reveal the structural variations and influence of Arp2/3 diversity on actin networks in vitro.

2. Cellular function of different Arp2/3 complexes With cells expressing specific Arp2/3 isoforms, we will use quantitative live cell imaging and cryoelectron tomography to reveal the dependence of cellular actin networks on Arp2/3 diversity and its functional consequences.

3. Developmental and physiological role of individual Arp2/3 complexes. With genetically modified cultured myofibers and transgenic mice, we will use an array of imaging approaches to reveal the contribution of different Arp2/3 family members to muscle development, structure and physiology.

Our interdisciplinary plan builds on the strengths of our three labs, takes advantage of unique reagents and powerful model systems, and will allow us to determine how Arp2/3 diversity contributes to biological complexity at multiple scales.

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The information about "ARPCOMPLEXITY" are provided by the European Opendata Portal: CORDIS opendata.

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