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ArpComplexity SIGNED

Defining the role of Arp2/3 complex diversity at multiple scales of biology

Total Cost €

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EC-Contrib. €

0

Partnership

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 ArpComplexity project word cloud

Explore the words cloud of the ArpComplexity project. It provides you a very rough idea of what is the project "ArpComplexity" about.

gain    hierarchies    biological    actin    influence    variations    mammals    contributes    branched    reveal    operation    cell    cryoelectron    networks    molecule    cryo    lab    microscopy    electron    human    genetically    physiology    reagents    seven    imaging    fluorescence    contribution    stability    array    single    transgenic    quantitative    cellular    multiple    shown    encoded    humans    critical    myofibers    stimulate    entity    family    takes    perform    model    function    interdisciplinary    isoforms    subunit    mice    powerful    complexity    structural    advantage    complexes    isoform    dramatically    functional    tomography    diversification    dependence    strengths    structure    synergistic    cultured    modified    basis    consisting    muscle    composition    labs    dynamic    eight    developmental    individual    gomes    risk    cells    diversity    builds    molecular    always    vitro    live    protein    members    scales    plan    subunits    physiological    expressing    arp2    sustainability    cytoskeleton    body    purified    biology   

Project "ArpComplexity" data sheet

The following table provides information about the project.

Coordinator
THE FRANCIS CRICK INSTITUTE LIMITED 

Organization address
address: 1 MIDLAND ROAD
city: LONDON
postcode: NW1 1AT
website: www.crick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 10˙715˙153 €
 EC max contribution 10˙715˙153 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-SyG
 Funding Scheme ERC-SyG
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2025-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE FRANCIS CRICK INSTITUTE LIMITED UK (LONDON) coordinator 4˙148˙087.00
2    BIRKBECK COLLEGE - UNIVERSITY OF LONDON UK (LONDON) participant 3˙359˙131.00
3    INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES PT (LISBOA) participant 3˙207˙935.00

Map

 Project objective

The actin cytoskeleton of the cell is critical for the complex, integrated processes associated with development, operation and sustainability of the human body. The Arp2/3 complex consisting of seven protein subunits is essential to stimulate dynamic branched actin networks needed for multiple cellular processes. The Arp2/3 complex has always been considered as a single entity, but in humans and other mammals, three of the Arp2/3 complex subunits are encoded by two isoforms, thus allowing the formation of eight distinct Arp2/3 complexes. The Way lab has shown that Arp2/3 subunit composition dramatically affects the formation and stability of branched actin networks. The Way and Gomes labs have shown how specific Arp2/3 isoforms are essential for muscle development.

Our synergistic, high-risk, high-gain goal is to define the role of Arp2/3 complex diversity at three hierarchies of biology:

1. Molecular basis of Arp2/3 diversification With purified isoform-specific complexes we will perform cryo-electron microscopy and single molecule fluorescence microscopy to reveal the structural variations and influence of Arp2/3 diversity on actin networks in vitro.

2. Cellular function of different Arp2/3 complexes With cells expressing specific Arp2/3 isoforms, we will use quantitative live cell imaging and cryoelectron tomography to reveal the dependence of cellular actin networks on Arp2/3 diversity and its functional consequences.

3. Developmental and physiological role of individual Arp2/3 complexes. With genetically modified cultured myofibers and transgenic mice, we will use an array of imaging approaches to reveal the contribution of different Arp2/3 family members to muscle development, structure and physiology.

Our interdisciplinary plan builds on the strengths of our three labs, takes advantage of unique reagents and powerful model systems, and will allow us to determine how Arp2/3 diversity contributes to biological complexity at multiple scales.

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The information about "ARPCOMPLEXITY" are provided by the European Opendata Portal: CORDIS opendata.

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