Opendata, web and dolomites

ArpComplexity SIGNED

Defining the role of Arp2/3 complex diversity at multiple scales of biology

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ArpComplexity project word cloud

Explore the words cloud of the ArpComplexity project. It provides you a very rough idea of what is the project "ArpComplexity" about.

influence    family    shown    mammals    hierarchies    live    physiological    dramatically    physiology    dynamic    subunit    quantitative    array    protein    cultured    diversity    variations    biology    biological    strengths    branched    gomes    mice    multiple    myofibers    advantage    perform    eight    scales    developmental    vitro    powerful    seven    cytoskeleton    diversification    plan    encoded    reveal    individual    isoforms    molecular    risk    contribution    gain    humans    cellular    modified    function    isoform    structure    cell    imaging    microscopy    transgenic    muscle    stimulate    functional    cryo    molecule    tomography    networks    complexes    actin    critical    contributes    subunits    model    purified    operation    interdisciplinary    electron    labs    stability    lab    consisting    cells    cryoelectron    synergistic    single    dependence    fluorescence    reagents    genetically    arp2    basis    entity    human    members    body    expressing    sustainability    composition    always    complexity    builds    takes    structural   

Project "ArpComplexity" data sheet

The following table provides information about the project.

Coordinator
THE FRANCIS CRICK INSTITUTE LIMITED 

Organization address
address: 1 MIDLAND ROAD
city: LONDON
postcode: NW1 1AT
website: www.crick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 10˙715˙153 €
 EC max contribution 10˙715˙153 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-SyG
 Funding Scheme ERC-SyG
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2025-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE FRANCIS CRICK INSTITUTE LIMITED UK (LONDON) coordinator 4˙148˙087.00
2    BIRKBECK COLLEGE - UNIVERSITY OF LONDON UK (LONDON) participant 3˙359˙131.00
3    INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES PT (LISBOA) participant 3˙207˙935.00

Map

 Project objective

The actin cytoskeleton of the cell is critical for the complex, integrated processes associated with development, operation and sustainability of the human body. The Arp2/3 complex consisting of seven protein subunits is essential to stimulate dynamic branched actin networks needed for multiple cellular processes. The Arp2/3 complex has always been considered as a single entity, but in humans and other mammals, three of the Arp2/3 complex subunits are encoded by two isoforms, thus allowing the formation of eight distinct Arp2/3 complexes. The Way lab has shown that Arp2/3 subunit composition dramatically affects the formation and stability of branched actin networks. The Way and Gomes labs have shown how specific Arp2/3 isoforms are essential for muscle development.

Our synergistic, high-risk, high-gain goal is to define the role of Arp2/3 complex diversity at three hierarchies of biology:

1. Molecular basis of Arp2/3 diversification With purified isoform-specific complexes we will perform cryo-electron microscopy and single molecule fluorescence microscopy to reveal the structural variations and influence of Arp2/3 diversity on actin networks in vitro.

2. Cellular function of different Arp2/3 complexes With cells expressing specific Arp2/3 isoforms, we will use quantitative live cell imaging and cryoelectron tomography to reveal the dependence of cellular actin networks on Arp2/3 diversity and its functional consequences.

3. Developmental and physiological role of individual Arp2/3 complexes. With genetically modified cultured myofibers and transgenic mice, we will use an array of imaging approaches to reveal the contribution of different Arp2/3 family members to muscle development, structure and physiology.

Our interdisciplinary plan builds on the strengths of our three labs, takes advantage of unique reagents and powerful model systems, and will allow us to determine how Arp2/3 diversity contributes to biological complexity at multiple scales.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ARPCOMPLEXITY" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ARPCOMPLEXITY" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

T-NHL SUPRESSORS (2019)

Tumor suppressor pathways counteracting oncogenic immune receptor signaling in T-Cell Lymphoma

Read More  

NanoPD_P (2020)

High throughput multiplexed trace-analyte screening for diagnostics applications

Read More  

Life-Inspired (2019)

Life-inspired complex molecular systems controlled by enzymatic reaction networks

Read More