GUTPEPTIDES SIGNED
Novel therapeutic approaches to improve gastrointestinal wound healing
Total Cost €
0EC-Contrib. €
0Partnership
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0GUTPEPTIDES project word cloud
Explore the words cloud of the GUTPEPTIDES project. It provides you a very rough idea of what is the project "GUTPEPTIDES" about.
Project "GUTPEPTIDES" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITAT WIEN
Organization address contact info |
| Coordinator Country | Austria [AT] |
| Total cost | 1˙487˙396 € |
| EC max contribution | 1˙487˙396 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2016-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-09-01 to 2022-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITAT WIEN | AT (WIEN) | coordinator | 1˙487˙396.00 |
Map
Project objective
The gastrointestinal epithelium is a major physical barrier that protects us from diverse and potentially immunogenic or toxic content. A compromised epithelium results in increased permeability to such content, thus leading to inflammation, immune response, pain, and diseases, such as irritable bowel syndrome and inflammatory bowel disease. A therapeutic strategy that controls inflammation and restores the barrier represents an innovative approach for the prevention and treatment of such diseases. This proposal focuses on how gut peptides regulate epithelial protection and repair, and explores novel therapeutic opportunities by targeting gut receptors that become accessible once the epithelium is compromised. We propose to tackle the overall aim of improving gastrointestinal wound healing via three complementary objectives: (I) to investigate the therapeutic potential of the oxytocin receptor during gastrointestinal inflammation, (II) to elucidate the mechanism of trefoil factor peptide-induced gastrointestinal wound healing, and (III) to discover and characterise novel ligands suitable for epithelial repair. To achieve these objectives, we employ a multidisciplinary approach that includes state-of-the-art peptide synthesis, scaffold grafting, pharmacology, gut stability and wound healing assays, and inflammatory mouse models. We will develop probes to study the mechanisms of action at a molecular level that is not possible with current tools, and explore the biological diversity of venoms for novel therapeutic leads. This project will significantly advance our understanding of epithelial protection/repair and reveal drug targets that treat the source of the problems rather than the symptoms. This project has the potential to change the way we think about treating gut disorders and how to develop peptide therapeutics, and it will pave the way towards the intriguing and longer-term goal of modulating the central nervous system via the gut-brain axis.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Zita LiutkeviÄiÅ«tÄ—, Esther Gil-Mansilla, Thomas Eder, Barbara Casillas-Pérez, Maria Giulia Di Giglio, Edin Muratspahić, Florian Grebien, Thomas Rattei, Markus Muttenthaler, Sylvia Cremer, Christian W. Gruber Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity published pages: 6808-6821, ISSN: 0892-6638, DOI: 10.1096/fj.201800443 |
The FASEB Journal 32/12 | 2019-05-23 |
| 2018 |
Anne C. Conibear, Markus Muttenthaler Advancing the Frontiers of Chemical Protein Synthesis—The 7th CPS Meeting, Haifa, Israel published pages: 247-254, ISSN: 2451-9456, DOI: 10.1016/j.chembiol.2018.03.001 |
Cell Chemical Biology 25/3 | 2019-05-23 |
| 2019 |
Nayara Braga Emidio, Werner Hoffmann, Stuart M. Brierley, Markus Muttenthaler Trefoil Factor Family: Unresolved Questions and Clinical Perspectives published pages: 387-390, ISSN: 0968-0004, DOI: 10.1016/j.tibs.2019.01.004 |
Trends in Biochemical Sciences 44/5 | 2019-05-23 |
| 2018 |
Volker Herzig, Aline de Araujo, Kathryn Greenwood, Yanni Chin, Monique Windley, Youmie Chong, Markus Muttenthaler, Mehdi Mobli, Neil Audsley, Graham Nicholson, Paul Alewood, Glenn King Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides published pages: 90, ISSN: 2227-9059, DOI: 10.3390/biomedicines6030090 |
Biomedicines 6/3 | 2019-05-23 |
| 2018 |
Sarah Arrowsmith, Peter Keov, Markus Muttenthaler, Christian W. Gruber Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development published pages: , ISSN: 1940-087X, DOI: 10.3791/56639 |
Journal of Visualized Experiments 131 | 2019-05-23 |
| 2017 |
Markus Muttenthaler, Åsa Andersson, Irina Vetter, Rohit Menon, Marta Busnelli, Lotten Ragnarsson, Christian Bergmayr, Sarah Arrowsmith, Jennifer R. Deuis, Han Sheng Chiu, Nathan J. Palpant, Margaret O’Brien, Terry J. Smith, Susan Wray, Inga D. Neumann, Christian W. Gruber, Richard J. Lewis, Paul F. Alewood Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species published pages: eaan3398, ISSN: 1937-9145, DOI: 10.1126/scisignal.aan3398 |
Science Signaling 10/508 | 2019-05-23 |
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