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GUTPEPTIDES SIGNED

Novel therapeutic approaches to improve gastrointestinal wound healing

Total Cost €

EC-Contrib. €

Partnership

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GUTPEPTIDES project word cloud

Explore the words cloud of the GUTPEPTIDES project. It provides you a very rough idea of what is the project "GUTPEPTIDES" about.

nervous biological suitable explores complementary elucidate oxytocin probes prevention employ gastrointestinal permeability barrier regulate treating diseases symptoms once therapeutics reveal wound mechanism modulating immunogenic source disorders synthesis diversity therapeutic innovative models drug toxic diverse treat venoms intriguing leads restores trefoil strategy mechanisms pain action brain bowel significantly content healing accessible scaffold pharmacology syndrome peptide protects grafting treatment think irritable explore disease tackle controls mouse central protection physical characterise inflammatory compromised receptors epithelium discover peptides epithelial immune axis tools potentially longer gut pave assays repair stability ligands inflammation multidisciplinary receptor molecular

Project "GUTPEPTIDES" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAT WIEN Organization address address: UNIVERSITATSRING 1 city: WIEN postcode: 1010 website: www.univie.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Austria [AT]
Total cost	1˙487˙396 €
EC max contribution	1˙487˙396 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-STG
Funding Scheme	ERC-STG
Starting year	2017
Duration (year-month-day)	from 2017-09-01 to 2022-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAT WIEN UNIVERSITAT WIEN Organization address address: UNIVERSITATSRING 1 city: WIEN postcode: 1010 website: www.univie.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	coordinator	1˙487˙396.00

Map

Project objective

The gastrointestinal epithelium is a major physical barrier that protects us from diverse and potentially immunogenic or toxic content. A compromised epithelium results in increased permeability to such content, thus leading to inflammation, immune response, pain, and diseases, such as irritable bowel syndrome and inflammatory bowel disease. A therapeutic strategy that controls inflammation and restores the barrier represents an innovative approach for the prevention and treatment of such diseases. This proposal focuses on how gut peptides regulate epithelial protection and repair, and explores novel therapeutic opportunities by targeting gut receptors that become accessible once the epithelium is compromised. We propose to tackle the overall aim of improving gastrointestinal wound healing via three complementary objectives: (I) to investigate the therapeutic potential of the oxytocin receptor during gastrointestinal inflammation, (II) to elucidate the mechanism of trefoil factor peptide-induced gastrointestinal wound healing, and (III) to discover and characterise novel ligands suitable for epithelial repair. To achieve these objectives, we employ a multidisciplinary approach that includes state-of-the-art peptide synthesis, scaffold grafting, pharmacology, gut stability and wound healing assays, and inflammatory mouse models. We will develop probes to study the mechanisms of action at a molecular level that is not possible with current tools, and explore the biological diversity of venoms for novel therapeutic leads. This project will significantly advance our understanding of epithelial protection/repair and reveal drug targets that treat the source of the problems rather than the symptoms. This project has the potential to change the way we think about treating gut disorders and how to develop peptide therapeutics, and it will pave the way towards the intriguing and longer-term goal of modulating the central nervous system via the gut-brain axis.

Publications

List of publications.
year	authors and title	journal	last update
2018	Zita LiutkeviÄiÅ«tÄ—, Esther Gil-Mansilla, Thomas Eder, Barbara Casillas-PÃ©rez, Maria Giulia Di Giglio, Edin MuratspahiÄ‡, Florian Grebien, Thomas Rattei, Markus Muttenthaler, Sylvia Cremer, Christian W. Gruber Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity published pages: 6808-6821, ISSN: 0892-6638, DOI: 10.1096/fj.201800443	The FASEB Journal 32/12	2019-05-23
2018	Anne C. Conibear, Markus Muttenthaler Advancing the Frontiers of Chemical Protein Synthesisâ€”The 7th CPS Meeting, Haifa, Israel published pages: 247-254, ISSN: 2451-9456, DOI: 10.1016/j.chembiol.2018.03.001	Cell Chemical Biology 25/3	2019-05-23
2019	Nayara Braga Emidio, Werner Hoffmann, Stuart M. Brierley, Markus Muttenthaler Trefoil Factor Family: Unresolved Questions and Clinical Perspectives published pages: 387-390, ISSN: 0968-0004, DOI: 10.1016/j.tibs.2019.01.004	Trends in Biochemical Sciences 44/5	2019-05-23
2018	Volker Herzig, Aline de Araujo, Kathryn Greenwood, Yanni Chin, Monique Windley, Youmie Chong, Markus Muttenthaler, Mehdi Mobli, Neil Audsley, Graham Nicholson, Paul Alewood, Glenn King Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides published pages: 90, ISSN: 2227-9059, DOI: 10.3390/biomedicines6030090	Biomedicines 6/3	2019-05-23
2018	Sarah Arrowsmith, Peter Keov, Markus Muttenthaler, Christian W. Gruber Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development published pages: , ISSN: 1940-087X, DOI: 10.3791/56639	Journal of Visualized Experiments 131	2019-05-23
2017	Markus Muttenthaler, Ã…sa Andersson, Irina Vetter, Rohit Menon, Marta Busnelli, Lotten Ragnarsson, Christian Bergmayr, Sarah Arrowsmith, Jennifer R. Deuis, Han Sheng Chiu, Nathan J. Palpant, Margaret Oâ€™Brien, Terry J. Smith, Susan Wray, Inga D. Neumann, Christian W. Gruber, Richard J. Lewis, Paul F. Alewood Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species published pages: eaan3398, ISSN: 1937-9145, DOI: 10.1126/scisignal.aan3398	Science Signaling 10/508	2019-05-23

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