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GUTPEPTIDES SIGNED

Novel therapeutic approaches to improve gastrointestinal wound healing

Total Cost €

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EC-Contrib. €

0

Partnership

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 GUTPEPTIDES project word cloud

Explore the words cloud of the GUTPEPTIDES project. It provides you a very rough idea of what is the project "GUTPEPTIDES" about.

receptors    probes    mouse    treat    peptides    controls    barrier    modulating    tools    pharmacology    treatment    therapeutics    molecular    restores    longer    drug    explores    source    prevention    immunogenic    content    symptoms    reveal    healing    strategy    intriguing    potentially    disorders    disease    ligands    regulate    protection    discover    nervous    mechanisms    significantly    tackle    action    inflammatory    physical    inflammation    syndrome    epithelial    diverse    explore    repair    think    therapeutic    leads    suitable    biological    immune    complementary    accessible    employ    assays    central    wound    once    grafting    compromised    bowel    venoms    oxytocin    models    protects    axis    innovative    multidisciplinary    brain    toxic    elucidate    characterise    synthesis    scaffold    pain    treating    pave    diseases    permeability    irritable    epithelium    stability    gut    gastrointestinal    receptor    diversity    trefoil    mechanism    peptide   

Project "GUTPEPTIDES" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT WIEN 

Organization address
address: UNIVERSITATSRING 1
city: WIEN
postcode: 1010
website: www.univie.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 1˙487˙396 €
 EC max contribution 1˙487˙396 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT WIEN AT (WIEN) coordinator 1˙487˙396.00

Map

 Project objective

The gastrointestinal epithelium is a major physical barrier that protects us from diverse and potentially immunogenic or toxic content. A compromised epithelium results in increased permeability to such content, thus leading to inflammation, immune response, pain, and diseases, such as irritable bowel syndrome and inflammatory bowel disease. A therapeutic strategy that controls inflammation and restores the barrier represents an innovative approach for the prevention and treatment of such diseases. This proposal focuses on how gut peptides regulate epithelial protection and repair, and explores novel therapeutic opportunities by targeting gut receptors that become accessible once the epithelium is compromised. We propose to tackle the overall aim of improving gastrointestinal wound healing via three complementary objectives: (I) to investigate the therapeutic potential of the oxytocin receptor during gastrointestinal inflammation, (II) to elucidate the mechanism of trefoil factor peptide-induced gastrointestinal wound healing, and (III) to discover and characterise novel ligands suitable for epithelial repair. To achieve these objectives, we employ a multidisciplinary approach that includes state-of-the-art peptide synthesis, scaffold grafting, pharmacology, gut stability and wound healing assays, and inflammatory mouse models. We will develop probes to study the mechanisms of action at a molecular level that is not possible with current tools, and explore the biological diversity of venoms for novel therapeutic leads. This project will significantly advance our understanding of epithelial protection/repair and reveal drug targets that treat the source of the problems rather than the symptoms. This project has the potential to change the way we think about treating gut disorders and how to develop peptide therapeutics, and it will pave the way towards the intriguing and longer-term goal of modulating the central nervous system via the gut-brain axis.

 Publications

year authors and title journal last update
List of publications.
2018 Zita Liutkevičiūtė, Esther Gil-Mansilla, Thomas Eder, Barbara Casillas-Pérez, Maria Giulia Di Giglio, Edin Muratspahić, Florian Grebien, Thomas Rattei, Markus Muttenthaler, Sylvia Cremer, Christian W. Gruber
Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity
published pages: 6808-6821, ISSN: 0892-6638, DOI: 10.1096/fj.201800443
The FASEB Journal 32/12 2019-05-23
2018 Anne C. Conibear, Markus Muttenthaler
Advancing the Frontiers of Chemical Protein Synthesis—The 7th CPS Meeting, Haifa, Israel
published pages: 247-254, ISSN: 2451-9456, DOI: 10.1016/j.chembiol.2018.03.001
Cell Chemical Biology 25/3 2019-05-23
2019 Nayara Braga Emidio, Werner Hoffmann, Stuart M. Brierley, Markus Muttenthaler
Trefoil Factor Family: Unresolved Questions and Clinical Perspectives
published pages: 387-390, ISSN: 0968-0004, DOI: 10.1016/j.tibs.2019.01.004
Trends in Biochemical Sciences 44/5 2019-05-23
2018 Volker Herzig, Aline de Araujo, Kathryn Greenwood, Yanni Chin, Monique Windley, Youmie Chong, Markus Muttenthaler, Mehdi Mobli, Neil Audsley, Graham Nicholson, Paul Alewood, Glenn King
Evaluation of Chemical Strategies for Improving the Stability and Oral Toxicity of Insecticidal Peptides
published pages: 90, ISSN: 2227-9059, DOI: 10.3390/biomedicines6030090
Biomedicines 6/3 2019-05-23
2018 Sarah Arrowsmith, Peter Keov, Markus Muttenthaler, Christian W. Gruber
Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development
published pages: , ISSN: 1940-087X, DOI: 10.3791/56639
Journal of Visualized Experiments 131 2019-05-23
2017 Markus Muttenthaler, Åsa Andersson, Irina Vetter, Rohit Menon, Marta Busnelli, Lotten Ragnarsson, Christian Bergmayr, Sarah Arrowsmith, Jennifer R. Deuis, Han Sheng Chiu, Nathan J. Palpant, Margaret O’Brien, Terry J. Smith, Susan Wray, Inga D. Neumann, Christian W. Gruber, Richard J. Lewis, Paul F. Alewood
Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species
published pages: eaan3398, ISSN: 1937-9145, DOI: 10.1126/scisignal.aan3398
Science Signaling 10/508 2019-05-23

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