Opendata, web and dolomites

MultiplexGenomics SIGNED

Exploring the Epigenome by Multiplexed Physical Mapping of Individual Chromosomes

Total Cost €


EC-Contrib. €






 MultiplexGenomics project word cloud

Explore the words cloud of the MultiplexGenomics project. It provides you a very rough idea of what is the project "MultiplexGenomics" about.

personalized    integrate    uncover    generation    attached    electro    observables    contrast    life    successful    stretched    nanochannels    chromosomes    full    code    critical    optical    unmasking    genetic    cell    opening    multiplexgenomics    missing    chromosomal    electric    tagging    medicine    scales    physical    hidden    content    inside    resolution    multiplexed    combining    chemical    cancer    interplay    single    electrical    spot    multiplexing    view    sequencing    acquisition    molecule    mapping    arrays    epigenetic    native    signatures    repertoire    networks    utilize    genome    detect    cover    modifications    groundbreaking    spectral    multiple    toolbox    discovery    epigenome    completion    regulation    simultaneous    basic    sensing    read    profiling    health    genomic    biochemical    horizons    blind    disease    imager    length    experimental    obscuring    accessible    never    tags    breast    framework    labeling    time    discover    expression    reactions    gene    predisposition    equipped    dna    nanopore    individual    nevertheless    markers    correlations    nanochannel    constitutes    revealing    molecules    picture   

Project "MultiplexGenomics" data sheet

The following table provides information about the project.


Organization address
address: RAMAT AVIV
city: TEL AVIV
postcode: 69978

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 2˙750˙000 €
 EC max contribution 2˙750˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TEL AVIV UNIVERSITY IL (TEL AVIV) coordinator 2˙750˙000.00


 Project objective

The genome is composed of the genetic code and a rich repertoire of epigenetic chemical DNA modifications, the Epigenome, with distinct signatures in health and disease. Unmasking the interplay between different genomic features is critical for understanding the operating system of life. Specifically, revealing long-range epigenetic regulation may uncover predisposition to cancer. Nevertheless, due to the short read-length of single-cell next-generation sequencing, there is no method today that can integrate multiple genomic observables, on the same genome and at the same time. The missing picture constitutes a major genomic “blind spot”, obscuring epigenetic regulation of gene expression. This project aims to provide a multiplexed view of the genome never before accessible. I will utilize single-molecule physical and chemical mapping of individual chromosomes to discover long-range epigenetic correlations, focusing on markers for predisposition to breast cancer. I will approach multiplexing by applying optical and electrical sensing concepts to detect chemical tags attached to long genomic DNA molecules. Equipped with a toolbox of biochemical DNA labeling reactions, I will develop a unique spectral imager for simultaneous acquisition of high-content genomic information from DNA stretched in nanochannel arrays. DNA tagging will also be used to enhance electrical contrast for nanopore epigenetic sequencing. Finally, by combining electric sensing inside nanochannels I will develop new integrated devices for electro-optical genomic analysis. Together, these developments cover the full range of genomic length scales and resolution. MultiplexGenomics will establish a groundbreaking experimental framework for genetic/epigenetic profiling of native chromosomal DNA. A successful completion of this project will make possible the discovery of novel control networks and hidden long-range regulation, opening new horizons for basic genomic research and personalized medicine.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MULTIPLEXGENOMICS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MULTIPLEXGENOMICS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

SUExp (2018)

Strategic Uncertainty: An Experimental Investigation

Read More  

NeuroMag (2019)

The Neurological Basis of the Magnetic Sense

Read More  

RTMFRM (2019)

Room Temperature Magnetic Resonance Force Microscopy

Read More