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MultiplexGenomics SIGNED

Exploring the Epigenome by Multiplexed Physical Mapping of Individual Chromosomes

Total Cost €

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EC-Contrib. €

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Partnership

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 MultiplexGenomics project word cloud

Explore the words cloud of the MultiplexGenomics project. It provides you a very rough idea of what is the project "MultiplexGenomics" about.

cover    electric    epigenome    expression    health    completion    disease    tagging    toolbox    genome    integrate    individual    time    multiplexed    framework    labeling    read    contrast    nevertheless    acquisition    mapping    physical    sequencing    gene    revealing    blind    electro    cancer    observables    dna    equipped    molecule    missing    attached    accessible    modifications    optical    never    native    basic    repertoire    chemical    electrical    length    scales    networks    constitutes    picture    opening    tags    unmasking    single    groundbreaking    molecules    markers    cell    profiling    full    horizons    simultaneous    sensing    multiple    biochemical    experimental    generation    combining    genomic    predisposition    inside    chromosomal    hidden    obscuring    spot    epigenetic    successful    nanopore    genetic    spectral    imager    signatures    view    critical    resolution    personalized    multiplexgenomics    reactions    interplay    discovery    nanochannels    code    nanochannel    correlations    discover    breast    detect    stretched    medicine    life    arrays    utilize    multiplexing    content    chromosomes    uncover    regulation   

Project "MultiplexGenomics" data sheet

The following table provides information about the project.

Coordinator
TEL AVIV UNIVERSITY 

Organization address
address: RAMAT AVIV
city: TEL AVIV
postcode: 69978
website: http://www.tau.ac.il/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 2˙750˙000 €
 EC max contribution 2˙750˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-COG
 Funding Scheme ERC-COG
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2024-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TEL AVIV UNIVERSITY IL (TEL AVIV) coordinator 2˙750˙000.00

Map

 Project objective

The genome is composed of the genetic code and a rich repertoire of epigenetic chemical DNA modifications, the Epigenome, with distinct signatures in health and disease. Unmasking the interplay between different genomic features is critical for understanding the operating system of life. Specifically, revealing long-range epigenetic regulation may uncover predisposition to cancer. Nevertheless, due to the short read-length of single-cell next-generation sequencing, there is no method today that can integrate multiple genomic observables, on the same genome and at the same time. The missing picture constitutes a major genomic “blind spot”, obscuring epigenetic regulation of gene expression. This project aims to provide a multiplexed view of the genome never before accessible. I will utilize single-molecule physical and chemical mapping of individual chromosomes to discover long-range epigenetic correlations, focusing on markers for predisposition to breast cancer. I will approach multiplexing by applying optical and electrical sensing concepts to detect chemical tags attached to long genomic DNA molecules. Equipped with a toolbox of biochemical DNA labeling reactions, I will develop a unique spectral imager for simultaneous acquisition of high-content genomic information from DNA stretched in nanochannel arrays. DNA tagging will also be used to enhance electrical contrast for nanopore epigenetic sequencing. Finally, by combining electric sensing inside nanochannels I will develop new integrated devices for electro-optical genomic analysis. Together, these developments cover the full range of genomic length scales and resolution. MultiplexGenomics will establish a groundbreaking experimental framework for genetic/epigenetic profiling of native chromosomal DNA. A successful completion of this project will make possible the discovery of novel control networks and hidden long-range regulation, opening new horizons for basic genomic research and personalized medicine.

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The information about "MULTIPLEXGENOMICS" are provided by the European Opendata Portal: CORDIS opendata.

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