Opendata, web and dolomites

PhotoArM SIGNED

Directed Evolution of Photoredox Powered Artificial Metalloenzymes for Stereodivergent Catalysis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 PhotoArM project word cloud

Explore the words cloud of the PhotoArM project. It provides you a very rough idea of what is the project "PhotoArM" about.

linear    metallophotoredox    stereodivergent    reaction    small    lactam    display    complementarity    attractive    hold    reactions    inside    catalysis    interface    sensitive    levels    nickel    groups    residues    give    light    metal    emerged    stereocentres    difficult    suitably    created    unexplored    monocyclic    diastereoisomers    concomitantly    pocket    turnover    inert    methodology    mutagenesis    synthetically    scaffold    nearby    protein    tools    reactive    synthetic    site    coupling    induce    artificial    generally    functionalised    quantity    racemic    acid    active    bromoalkane    catalytic    efficient    abundant    reactivity    full    photocatalyst    mild    powerful    intramolecular    metalloenzymes    chemistry    substrates    though    valuable    drawback    photoredox    enzyme    shell    selectivity    derivative    potentially    dramatically    sp3    cross    repertoire    beneficially    impressive    anchoring    pharmaceutical    activate    secondary    intermediates    independently    sphere    subsequently    catalyst    functional    compound    transition    amino    sustainable    beta   

Project "PhotoArM" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT BASEL 

Organization address
address: PETERSPLATZ 1
city: BASEL
postcode: 4051
website: www.unibas.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 191˙149 €
 EC max contribution 191˙149 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT BASEL CH (BASEL) coordinator 191˙149.00

Map

 Project objective

Artificial metalloenzymes have recently emerged as powerful tools to address the ever-growing requirements of chemistry to become more efficient and sustainable. This methodology involves anchoring a reactive transition metal catalyst within a protein to exploit the secondary coordination sphere created around the new active site, which can induce selectivity in reactions and improve turnover numbers. Concomitantly, photoredox and metallophotoredox catalysis, where a small quantity of a light sensitive compound allows non-traditional reactivity though open shell reactive intermediates, has also developed dramatically in recent years. The impressive reaction repertoire is especially synthetically attractive due to the mild conditions required and the ability to activate abundant and generally more inert functional groups. However, the current drawback to this methodology is the high levels of control needed to give the reactions their full synthetic potential. This is where the two fields display complementarity with an unexplored interface: Photoredox Artificial Metalloenzymes. By anchoring a nickel catalyst inside an enzyme pocket with a nearby photocatalyst, it should be possible to control catalytic reactivity by mutagenesis of residues in the secondary coordination sphere. In the proposed case of an sp3-sp3 cross-coupling reaction between a racemic amino acid derivative and bromoalkane, this could potentially allow control over both new stereocentres independently to achieve stereodivergent catalysis. It is subsequently proposed that this methodology could be adapted to include intramolecular cross-coupling reactions, which would beneficially allow access to the valuable monocyclic β-lactam scaffold from suitably functionalised linear substrates. If possible, this may allow efficient access to diastereoisomers potentially difficult to access by other means, which may hold unexplored pharmaceutical potential.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PHOTOARM" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PHOTOARM" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

Mel.Photo.Protect (2019)

Unraveling the Photoprotecting Mechanism of Melanin - From a Library of Fragments to Simulation of Spectra and Function

Read More  

TOPOCIRCUS (2019)

Simulations of Topological Phases in Superconducting Circuits

Read More  

COLEX (2019)

Coopetition and Legislation in the Spanish Netherlands (1598-1665)

Read More