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PhotoArM SIGNED

Directed Evolution of Photoredox Powered Artificial Metalloenzymes for Stereodivergent Catalysis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PhotoArM project word cloud

Explore the words cloud of the PhotoArM project. It provides you a very rough idea of what is the project "PhotoArM" about.

methodology    mild    nickel    though    small    sphere    anchoring    light    inside    stereodivergent    catalytic    unexplored    enzyme    substrates    protein    subsequently    valuable    reactive    mutagenesis    artificial    full    groups    levels    induce    hold    sensitive    photoredox    functionalised    transition    repertoire    concomitantly    quantity    cross    intramolecular    interface    reactions    amino    impressive    site    stereocentres    inert    secondary    catalyst    activate    beneficially    pocket    complementarity    synthetic    abundant    sustainable    metallophotoredox    display    catalysis    scaffold    active    suitably    beta    functional    monocyclic    turnover    independently    sp3    selectivity    pharmaceutical    derivative    metalloenzymes    tools    synthetically    residues    lactam    linear    difficult    efficient    shell    drawback    metal    compound    generally    attractive    chemistry    coupling    powerful    acid    diastereoisomers    photocatalyst    dramatically    give    intermediates    reactivity    nearby    emerged    created    potentially    racemic    reaction    bromoalkane   

Project "PhotoArM" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAT BASEL 

Organization address
address: PETERSPLATZ 1
city: BASEL
postcode: 4051
website: www.unibas.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 191˙149 €
 EC max contribution 191˙149 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAT BASEL CH (BASEL) coordinator 191˙149.00

Map

 Project objective

Artificial metalloenzymes have recently emerged as powerful tools to address the ever-growing requirements of chemistry to become more efficient and sustainable. This methodology involves anchoring a reactive transition metal catalyst within a protein to exploit the secondary coordination sphere created around the new active site, which can induce selectivity in reactions and improve turnover numbers. Concomitantly, photoredox and metallophotoredox catalysis, where a small quantity of a light sensitive compound allows non-traditional reactivity though open shell reactive intermediates, has also developed dramatically in recent years. The impressive reaction repertoire is especially synthetically attractive due to the mild conditions required and the ability to activate abundant and generally more inert functional groups. However, the current drawback to this methodology is the high levels of control needed to give the reactions their full synthetic potential. This is where the two fields display complementarity with an unexplored interface: Photoredox Artificial Metalloenzymes. By anchoring a nickel catalyst inside an enzyme pocket with a nearby photocatalyst, it should be possible to control catalytic reactivity by mutagenesis of residues in the secondary coordination sphere. In the proposed case of an sp3-sp3 cross-coupling reaction between a racemic amino acid derivative and bromoalkane, this could potentially allow control over both new stereocentres independently to achieve stereodivergent catalysis. It is subsequently proposed that this methodology could be adapted to include intramolecular cross-coupling reactions, which would beneficially allow access to the valuable monocyclic β-lactam scaffold from suitably functionalised linear substrates. If possible, this may allow efficient access to diastereoisomers potentially difficult to access by other means, which may hold unexplored pharmaceutical potential.

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The information about "PHOTOARM" are provided by the European Opendata Portal: CORDIS opendata.

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