Opendata, web and dolomites

TaPPiNG-EPI SIGNED

Targeting Purinergic Pathway in drug-resistant epilepsy using human Neurons and Glia.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 TaPPiNG-EPI project word cloud

Explore the words cloud of the TaPPiNG-EPI project. It provides you a very rough idea of what is the project "TaPPiNG-EPI" about.

employable    replicated    tissue    disease    combined    tapping    experts    pharmacological    purinergic    antagonists    reporter    p2x7r    recurrent    collaborations    supervisor    brain    independence    types    65    record    patients    atp    excellent    million    pluripotent    worldwide    epileptic    academia    determined    contribution    human    epilepsy    signalling    stem    mice    host    people    anticonvulsant    transition    alone    activation    labs    tools    neurological    animal    receptor    live    expertise    rcsi    responding    modifying    outstanding    models    complemented    investigation    glia    neurons    interdisciplinary    cell    learning    neuroscientist    secondments    hyperexcitability    therapeutics    diverse    gated    tested    showing    give    academic    international    alterations    30    proposes    pathological    brings    disorder    me    epi    clinicians    gfp    rodent    emerged    components    treatment    resected    intersectoral    p2x7    training    industrial    seizures   

Project "TaPPiNG-EPI" data sheet

The following table provides information about the project.

Coordinator
ROYAL COLLEGE OF SURGEONS IN IRELAND 

Organization address
address: Saint Stephen's Green 123
city: DUBLIN
postcode: 2
website: www.rcsi.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 196˙590 €
 EC max contribution 196˙590 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-04-01   to  2021-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ROYAL COLLEGE OF SURGEONS IN IRELAND IE (DUBLIN) coordinator 196˙590.00

Map

 Project objective

Epilepsy is a neurological disorder characterized by recurrent seizures affecting 65 million people worldwide of which 6 million live in Europe alone with around 30% of patients not responding to currently available treatment. The ATP-gated P2X7 receptor (P2X7R) has recently emerged as a promising target for epilepsy, showing anticonvulsant and disease-modifying properties in animal models. However, to develop P2X7R-based therapeutics the cell types involved in pathological P2X7R activation must be determined, and whether results from rodent models can be replicated in human tissue must be tested. Using human induced pluripotent stem cell-derived neurons and glia and resected brain tissue from epileptic patients, TaPPiNG-EPI proposes to investigate the cell-specific alterations and pathological contribution in the P2X7R pathway and pharmacological targeting of hyperexcitability using P2X7R antagonists. These studies will be complemented by the investigation on the alterations in P2X7R pathway in GFP-P2X7 reporter mice available in the host institution (RCSI). Through international secondments and intersectoral collaborations TaPPiNG-EPI brings together experts in purinergic signalling, industrial partners, epilepsy clinicians as well as leading European academic labs with diverse expertise. The interdisciplinary and intersectoral components of TaPPiNG-EPI combined with international collaborations and secondments in academia, the excellent training record of the supervisor and RCSI and the outstanding resources for learning and development available at RCSI will give me the tools necessary to achieve research independence and my transition to a highly employable future neuroscientist with a focus on epilepsy.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "TAPPING-EPI" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "TAPPING-EPI" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

ToMComputations (2019)

How other minds are represented in the human brain: Neural computations underlying Theory of Mind

Read More  

POMOC (2019)

Charles IV and the power of marvellous objects

Read More  

MathematicsAnalogies (2019)

Mathematics Analogies

Read More