Opendata, web and dolomites

THERMOGUIDE SIGNED

Optimizing delivery and effectiveness of chemotherapy in breast cancer patients using thermotherapy under image-guidance

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 THERMOGUIDE project word cloud

Explore the words cloud of the THERMOGUIDE project. It provides you a very rough idea of what is the project "THERMOGUIDE" about.

region    deaths    surgery    chemo    drugs    strand    amplifies    clinical    sufficient    perfusion    smart    deep    administration    intact    wall    causes    focalized    chest    commercial    spatial    thermo    concentration    improves    67    generally    compatible    prevents    effect    inability    death    selectively    severe    outcomes    heated    treat    repair    breast    temperature    dna    anti    43    thermotherapy    area    tumour    adaptive    load    actually    41    3d    solutions    worldwide    522    tissue    membrane    induces    normal    drug    undergo    women    biological    despite    steering    mr    groundbreaking    heating    heat    2012    double    damage    patients    seated    chemotherapy    dose    systemic    extravasation    nor    break    administered    volumes    inhibits    selectivity    cancers    immune       thermosensitive    unfortunately    nano    diagnoses    full    near    carriers    bioavailability    therapy    conform    fluidity    experimental    cancer    precise    fold    primary    envisaged    cure    with    tumours    million    deg    hyperthermia   

Project "THERMOGUIDE" data sheet

The following table provides information about the project.

Coordinator
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM 

Organization address
address: DR MOLEWATERPLEIN 40
city: ROTTERDAM
postcode: 3015 GD
website: www.erasmusmc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 187˙572 €
 EC max contribution 187˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-07-16   to  2021-07-15

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) coordinator 187˙572.00

Map

 Project objective

With 1.67 million of diagnoses and 522,000 deaths in 2012, breast cancer is the most common and the leading cause of cancer death among women worldwide. Most patients with breast cancer undergo chemotherapy before or after surgery. Chemotherapy is generally applied as a systemic therapy, with only less than 1% of the administered drugs actually reach the tumour. This causes severe side-effects in normal tissue, and often prevents the administration of sufficient dose for effective cure. Thermotherapy, also known as hyperthermia, that is the increase of tumour temperature to 40-43°C, improves drug delivery at the tumour area and amplifies the anti-tumour effect of the drugs (biological and spatial selectivity). Despite this two-fold potential, thermo-chemotherapy is currently not used in breast cancer due to the inability to heat only the tumour area. Thermotherapy improves perfusion, extravasation and membrane fluidity in the heated region, leading to an increased bioavailability and drug concentration. Furthermore, heating above 41°C inhibits DNA double strand break damage repair and induces an anti-cancer immune response. As for the future potential of thermotherapy, it will be the key for the groundbreaking technology of thermosensitive smart nano-carriers, enabling a focalized delivery of chemotherapy load. Exploiting the full potential of my envisaged approach of improving clinical outcomes for primary breast cancer requires a precise application of thermotherapy. Unfortunately, current state-of-the-art commercial and experimental solutions do not conform to the intact breast, cannot selectively treat deep-seated tumours near the chest wall nor provide the 3D heat steering capabilities to specifically heat large tumour volumes. Therefore I propose this project with the main research goal to develop a novel, MR compatible thermotherapy system for MR-adaptive spatial and biological chemo-targeting in primary breast cancers.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "THERMOGUIDE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "THERMOGUIDE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

CLIMACY (2020)

Practices of Climate Diplomacy and Uneven Policy Responses on Climate Change on Human Mobility

Read More  

Photonic Radar (2019)

Implementation of Long Reach Hybrid Photonic Radar System and convergence over FSO and PON Networks

Read More  

DIGILEAD (2020)

Digital leadership, well-being and performance in organizations

Read More