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THERMOGUIDE SIGNED

Optimizing delivery and effectiveness of chemotherapy in breast cancer patients using thermotherapy under image-guidance

Total Cost €

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EC-Contrib. €

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Partnership

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 THERMOGUIDE project word cloud

Explore the words cloud of the THERMOGUIDE project. It provides you a very rough idea of what is the project "THERMOGUIDE" about.

surgery    tissue    wall    improves    induces    cancers    compatible    41    membrane    primary    bioavailability    precise    diagnoses    solutions    clinical    load    anti    generally    strand    chest    67    thermo    inability    undergo    causes    breast    region    severe    despite    hyperthermia    break    fold    actually    nano    repair    area    3d    inhibits    worldwide    prevents    therapy    focalized    mr    adaptive    unfortunately    intact    women    spatial    perfusion    drug    cancer    deg       experimental    administration    temperature    heating    fluidity    tumours    systemic    nor    administered    2012    43    carriers    conform    million    cure    chemotherapy    seated    biological    heat    amplifies    volumes    death    immune    concentration    extravasation    chemo    patients    drugs    full    double    with    damage    smart    deaths    selectivity    thermotherapy    deep    outcomes    dna    thermosensitive    near    steering    groundbreaking    dose    heated    sufficient    522    effect    tumour    normal    treat    commercial    envisaged    selectively   

Project "THERMOGUIDE" data sheet

The following table provides information about the project.

Coordinator
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM 

Organization address
address: DR MOLEWATERPLEIN 40
city: ROTTERDAM
postcode: 3015 GD
website: www.erasmusmc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 187˙572 €
 EC max contribution 187˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-07-16   to  2021-07-15

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) coordinator 187˙572.00

Map

 Project objective

With 1.67 million of diagnoses and 522,000 deaths in 2012, breast cancer is the most common and the leading cause of cancer death among women worldwide. Most patients with breast cancer undergo chemotherapy before or after surgery. Chemotherapy is generally applied as a systemic therapy, with only less than 1% of the administered drugs actually reach the tumour. This causes severe side-effects in normal tissue, and often prevents the administration of sufficient dose for effective cure. Thermotherapy, also known as hyperthermia, that is the increase of tumour temperature to 40-43°C, improves drug delivery at the tumour area and amplifies the anti-tumour effect of the drugs (biological and spatial selectivity). Despite this two-fold potential, thermo-chemotherapy is currently not used in breast cancer due to the inability to heat only the tumour area. Thermotherapy improves perfusion, extravasation and membrane fluidity in the heated region, leading to an increased bioavailability and drug concentration. Furthermore, heating above 41°C inhibits DNA double strand break damage repair and induces an anti-cancer immune response. As for the future potential of thermotherapy, it will be the key for the groundbreaking technology of thermosensitive smart nano-carriers, enabling a focalized delivery of chemotherapy load. Exploiting the full potential of my envisaged approach of improving clinical outcomes for primary breast cancer requires a precise application of thermotherapy. Unfortunately, current state-of-the-art commercial and experimental solutions do not conform to the intact breast, cannot selectively treat deep-seated tumours near the chest wall nor provide the 3D heat steering capabilities to specifically heat large tumour volumes. Therefore I propose this project with the main research goal to develop a novel, MR compatible thermotherapy system for MR-adaptive spatial and biological chemo-targeting in primary breast cancers.

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The information about "THERMOGUIDE" are provided by the European Opendata Portal: CORDIS opendata.

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