Opendata, web and dolomites

THERMOGUIDE SIGNED

Optimizing delivery and effectiveness of chemotherapy in breast cancer patients using thermotherapy under image-guidance

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 THERMOGUIDE project word cloud

Explore the words cloud of the THERMOGUIDE project. It provides you a very rough idea of what is the project "THERMOGUIDE" about.

unfortunately    undergo    generally    systemic    worldwide    death    treat    43    volumes    drugs    41    near    focalized    experimental    region    commercial    mr    damage    actually    primary    steering    outcomes    despite    nor    thermotherapy    anti    deg    heating    effect    selectivity    extravasation    surgery    hyperthermia    full    heated    522    tissue    area    dose    2012    concentration    with    perfusion    sufficient    thermosensitive    3d    groundbreaking    tumours    fluidity    therapy    deep    biological    patients    diagnoses    cancers    conform    intact    severe    bioavailability    seated    chest    immune    load    drug    inhibits    67    inability    envisaged    nano    cancer    dna    million    double    clinical       women    wall    chemo    administered    deaths    heat    strand    breast    spatial    prevents    temperature    thermo    solutions    improves    tumour    break    chemotherapy    administration    selectively    normal    amplifies    membrane    precise    carriers    fold    smart    induces    adaptive    cure    repair    causes    compatible   

Project "THERMOGUIDE" data sheet

The following table provides information about the project.

Coordinator
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM 

Organization address
address: DR MOLEWATERPLEIN 40
city: ROTTERDAM
postcode: 3015 GD
website: www.erasmusmc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 187˙572 €
 EC max contribution 187˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-07-16   to  2021-07-15

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) coordinator 187˙572.00

Map

 Project objective

With 1.67 million of diagnoses and 522,000 deaths in 2012, breast cancer is the most common and the leading cause of cancer death among women worldwide. Most patients with breast cancer undergo chemotherapy before or after surgery. Chemotherapy is generally applied as a systemic therapy, with only less than 1% of the administered drugs actually reach the tumour. This causes severe side-effects in normal tissue, and often prevents the administration of sufficient dose for effective cure. Thermotherapy, also known as hyperthermia, that is the increase of tumour temperature to 40-43°C, improves drug delivery at the tumour area and amplifies the anti-tumour effect of the drugs (biological and spatial selectivity). Despite this two-fold potential, thermo-chemotherapy is currently not used in breast cancer due to the inability to heat only the tumour area. Thermotherapy improves perfusion, extravasation and membrane fluidity in the heated region, leading to an increased bioavailability and drug concentration. Furthermore, heating above 41°C inhibits DNA double strand break damage repair and induces an anti-cancer immune response. As for the future potential of thermotherapy, it will be the key for the groundbreaking technology of thermosensitive smart nano-carriers, enabling a focalized delivery of chemotherapy load. Exploiting the full potential of my envisaged approach of improving clinical outcomes for primary breast cancer requires a precise application of thermotherapy. Unfortunately, current state-of-the-art commercial and experimental solutions do not conform to the intact breast, cannot selectively treat deep-seated tumours near the chest wall nor provide the 3D heat steering capabilities to specifically heat large tumour volumes. Therefore I propose this project with the main research goal to develop a novel, MR compatible thermotherapy system for MR-adaptive spatial and biological chemo-targeting in primary breast cancers.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "THERMOGUIDE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "THERMOGUIDE" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

BirthControlEnvirons (2019)

Contraception meets the environment: everyday contraceptive practices, politics, and futures in a toxic age

Read More  

MarshFlux (2020)

The effect of future global climate and land-use change on greenhouse gas fluxes and microbial processes in salt marshes

Read More  

VINCI (2020)

The Value of Information and Choice to Improve Control.

Read More