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Optimizing delivery and effectiveness of chemotherapy in breast cancer patients using thermotherapy under image-guidance

Total Cost €


EC-Contrib. €






 THERMOGUIDE project word cloud

Explore the words cloud of the THERMOGUIDE project. It provides you a very rough idea of what is the project "THERMOGUIDE" about.

focalized    systemic    diagnoses    steering    actually    hyperthermia    severe    smart    3d    break    seated    area    41    nano    carriers    cure    outcomes    surgery    deep    heating    67    administered    generally       dose    therapy    tumours    bioavailability    deg    strand    heat    fluidity    commercial    causes    biological    worldwide    inhibits    heated    damage    43    unfortunately    full    precise    chest    tissue    double    adaptive    fold    induces    wall    spatial    with    thermo    tumour    repair    primary    2012    breast    volumes    thermotherapy    clinical    extravasation    treat    administration    cancers    thermosensitive    drugs    temperature    near    load    normal    chemo    anti    patients    mr    women    region    intact    effect    solutions    compatible    sufficient    despite    immune    selectively    experimental    death    522    drug    nor    dna    conform    concentration    amplifies    improves    prevents    million    undergo    selectivity    perfusion    chemotherapy    cancer    deaths    groundbreaking    inability    membrane    envisaged   

Project "THERMOGUIDE" data sheet

The following table provides information about the project.


Organization address
postcode: 3015 GD

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 187˙572 €
 EC max contribution 187˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-07-16   to  2021-07-15


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

With 1.67 million of diagnoses and 522,000 deaths in 2012, breast cancer is the most common and the leading cause of cancer death among women worldwide. Most patients with breast cancer undergo chemotherapy before or after surgery. Chemotherapy is generally applied as a systemic therapy, with only less than 1% of the administered drugs actually reach the tumour. This causes severe side-effects in normal tissue, and often prevents the administration of sufficient dose for effective cure. Thermotherapy, also known as hyperthermia, that is the increase of tumour temperature to 40-43°C, improves drug delivery at the tumour area and amplifies the anti-tumour effect of the drugs (biological and spatial selectivity). Despite this two-fold potential, thermo-chemotherapy is currently not used in breast cancer due to the inability to heat only the tumour area. Thermotherapy improves perfusion, extravasation and membrane fluidity in the heated region, leading to an increased bioavailability and drug concentration. Furthermore, heating above 41°C inhibits DNA double strand break damage repair and induces an anti-cancer immune response. As for the future potential of thermotherapy, it will be the key for the groundbreaking technology of thermosensitive smart nano-carriers, enabling a focalized delivery of chemotherapy load. Exploiting the full potential of my envisaged approach of improving clinical outcomes for primary breast cancer requires a precise application of thermotherapy. Unfortunately, current state-of-the-art commercial and experimental solutions do not conform to the intact breast, cannot selectively treat deep-seated tumours near the chest wall nor provide the 3D heat steering capabilities to specifically heat large tumour volumes. Therefore I propose this project with the main research goal to develop a novel, MR compatible thermotherapy system for MR-adaptive spatial and biological chemo-targeting in primary breast cancers.

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The information about "THERMOGUIDE" are provided by the European Opendata Portal: CORDIS opendata.

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