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THERMOGUIDE SIGNED

Optimizing delivery and effectiveness of chemotherapy in breast cancer patients using thermotherapy under image-guidance

Total Cost €

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EC-Contrib. €

0

Partnership

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 THERMOGUIDE project word cloud

Explore the words cloud of the THERMOGUIDE project. It provides you a very rough idea of what is the project "THERMOGUIDE" about.

   43    3d    primary    522    thermotherapy    selectivity    load    tissue    adaptive    effect    concentration    with    compatible    volumes    cancers    inability    causes    chest    actually    double    chemotherapy    million    breast    tumours    tumour    fold    perfusion    repair    deg    diagnoses    despite    chemo    membrane    solutions    precise    outcomes    treat    dna    heat    undergo    spatial    sufficient    region    therapy    intact    deep    clinical    fluidity    dose    steering    improves    seated    full    67    cancer    women    41    prevents    commercial    cure    systemic    mr    administration    nano    2012    biological    heating    smart    area    amplifies    carriers    damage    break    death    conform    drugs    wall    experimental    groundbreaking    heated    thermo    extravasation    anti    severe    near    strand    temperature    worldwide    thermosensitive    inhibits    hyperthermia    immune    focalized    surgery    normal    unfortunately    bioavailability    administered    selectively    induces    drug    envisaged    generally    nor    patients    deaths   

Project "THERMOGUIDE" data sheet

The following table provides information about the project.

Coordinator
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM 

Organization address
address: DR MOLEWATERPLEIN 40
city: ROTTERDAM
postcode: 3015 GD
website: www.erasmusmc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 187˙572 €
 EC max contribution 187˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-07-16   to  2021-07-15

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) coordinator 187˙572.00

Map

 Project objective

With 1.67 million of diagnoses and 522,000 deaths in 2012, breast cancer is the most common and the leading cause of cancer death among women worldwide. Most patients with breast cancer undergo chemotherapy before or after surgery. Chemotherapy is generally applied as a systemic therapy, with only less than 1% of the administered drugs actually reach the tumour. This causes severe side-effects in normal tissue, and often prevents the administration of sufficient dose for effective cure. Thermotherapy, also known as hyperthermia, that is the increase of tumour temperature to 40-43°C, improves drug delivery at the tumour area and amplifies the anti-tumour effect of the drugs (biological and spatial selectivity). Despite this two-fold potential, thermo-chemotherapy is currently not used in breast cancer due to the inability to heat only the tumour area. Thermotherapy improves perfusion, extravasation and membrane fluidity in the heated region, leading to an increased bioavailability and drug concentration. Furthermore, heating above 41°C inhibits DNA double strand break damage repair and induces an anti-cancer immune response. As for the future potential of thermotherapy, it will be the key for the groundbreaking technology of thermosensitive smart nano-carriers, enabling a focalized delivery of chemotherapy load. Exploiting the full potential of my envisaged approach of improving clinical outcomes for primary breast cancer requires a precise application of thermotherapy. Unfortunately, current state-of-the-art commercial and experimental solutions do not conform to the intact breast, cannot selectively treat deep-seated tumours near the chest wall nor provide the 3D heat steering capabilities to specifically heat large tumour volumes. Therefore I propose this project with the main research goal to develop a novel, MR compatible thermotherapy system for MR-adaptive spatial and biological chemo-targeting in primary breast cancers.

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The information about "THERMOGUIDE" are provided by the European Opendata Portal: CORDIS opendata.

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