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deCrYPtion SIGNED

Decrypting Mycobacterium cytochrome P450 (CYP) physiological functions by testing hypotheses emitted form large-scale comparative genomics analysis

Total Cost €

0

EC-Contrib. €

0

Partnership

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 deCrYPtion project word cloud

Explore the words cloud of the deCrYPtion project. It provides you a very rough idea of what is the project "deCrYPtion" about.

p450    drugs    united    infection    genetics    supervision    antibiotics    incentives    centre    belonging    proteins    illustrates    perform    biochemical    groups    fundamental    complementary    belong    conserved    190    undertaken    validate    drug    frequently    agents    prove    responsible    orthologous    species    cyp    context    genus    hypotheses    family    more    pathogenic    protein    performed    kelly    lost    cyps    biodiversity    lives    mycobacterium    determinant    wales    deaths    livestock    stringent    genomics    kingdom    orphan    powerful    economic    infectious    functions    preliminary    university    human    unfortunately    cytochrome    attributed    resistances    combination    animals    million    considerations    appeared    prof    tuberculosis    mycobacterial    swansea    shown    action    decryption    extremely    organisms    antibiotic    representative    eradication    suppresses    worldwide    tb    experiments    physiological    encoded    inhibition    function    enzymes    causative    steven    2016    antimycobacterial   

Project "deCrYPtion" data sheet

The following table provides information about the project.

Coordinator
SWANSEA UNIVERSITY 

Organization address
address: SINGLETON PARK
city: SWANSEA
postcode: SA2 8PP
website: www.swan.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SWANSEA UNIVERSITY UK (SWANSEA) coordinator 212˙933.00

Map

 Project objective

More than 190 species belong to the Mycobacterium genus. Among those, several are pathogenic to human and animals. The high number of human lives lost and the economic consequences of livestock infection are important incentives in the control and eradication of the responsible organisms. M. tuberculosis, one of the causative agents of tuberculosis (TB), is the most problematic representative: in 2016, 1.7 million deaths worldwide have been attributed to TB. Like for other infectious organisms, antibiotic resistances have appeared in Mycobacterium. Thus, there is a fundamental need to develop new antimycobacterial drugs. The inhibition of enzymes belonging to the Cytochrome P450 (CYP) protein family has been shown to suppresses the growth of several Mycobacterium species, making CYPs targets for drug development. Unfortunately, most CYPs are considered orphan: proteins for which no physiological function is known. The deCrYPtion action aims to define the physiological function of a selected set of mycobacterial CYPs. It will prove determinant in the development of new antibiotics. I will perform a large-scale comparative genomics analysis of the CYPs encoded by Mycobacterium species, in order to define orthologous groups and identify, for each, conserved partners and pathway context. This approach is extremely powerful (even if not frequently used) and allow to propose physiological functions, based on the information obtained. Specific CYPs to be characterized will be selected based on a set of stringent considerations, including their potential as drug targets. A preliminary analysis illustrates the approach that will be used. A combination of complementary biochemical, genetics and physiological experiments will be performed to validate the hypotheses generated. deCrYPtion will be undertaken within the Centre for Cytochrome P450 Biodiversity, under the supervision of Prof Steven Kelly, at Swansea University (Wales, United Kingdom).

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