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anti-CRISPR SIGNED

Selection and evolution of phage-encoded anti-CRISPR genes

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 anti-CRISPR project word cloud

Explore the words cloud of the anti-CRISPR project. It provides you a very rough idea of what is the project "anti-CRISPR" about.

inhibition    constitute    evolution    examine    sequencing    coevolution    accessible    international    block    reinforce    exeter    career    everyone    complementary    public    ecological    skills    accredited    mathematically    protect    populations    inform    network    phage    expertise    reciprocally    viruses    multidisciplinary    evolve    world    genetic    dual    downstream    university    explore    cas    immune    experimental    experiments    racing    scientists    visibility    first    stability    crispr    combines    collaborator    mathematical    training    me    coevolve    quality    adapt    unexplored    anti    bioengineering    collaborative    biology    deep    ahead    communication    molecular    reveal    genes    ecology    scientific    bioinformatics    culture    running    engagement    researcher    bacteria    restore    encode    independent    predict    widen    avenues    co    whereas    escape    plan    centre    bases    worldwide    supervision    acr    science    medical    phages    influence    none    host    conservation    structures   

Project "anti-CRISPR" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EXETER 

Organization address
address: THE QUEEN'S DRIVE NORTHCOTE HOUSE
city: EXETER
postcode: EX4 4QJ
website: www.ex.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 224˙933 €
 EC max contribution 224˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EXETER UK (EXETER) coordinator 224˙933.00

Map

 Project objective

CRISPR-Cas immune systems protect bacteria against their viruses (phage). However, some phages encode anti-CRISPR (Acr) genes that block CRISPR-Cas activity. While the molecular understanding of Acr activities and structures are racing ahead, their impact on the ecology and evolution of phage/bacteria populations remains unexplored.

I first aim to identify the ecological factors that influence the selection for Acr genes, to explain why some phages encode many Acr whereas most encode none. Next, by running long-term co-culture experiments, I will examine whether CRISPR-Cas can evolve to escape Acr inhibition and whether Acr genes can reciprocally adapt to restore activity. These experiments will reveal how CRISPR-Cas and Acr coevolve and allow to mathematically predict the long-term stability of Acr activity. I will also explore the genetic bases of this coevolution through deep-sequencing analyses.

This multidisciplinary project combines my expertise in phage biology, that of the host in experimental evolution and bioinformatics and that of collaborator in mathematical modelling. It is expected to open new avenues of research for downstream medical and bioengineering applications.

This high-quality 'training-through-research' will allow me to widen my scientific expertise, develop essential complementary skills and constitute an international collaborative network. The visibility and impact of this research will be increased by a strong dissemination and communication plan. I also aim to reinforce my public engagement activities with a dual objective of making science accessible for everyone and inform about phage research.

Carrying out this project within the Centre for Ecology and Conservation at the University of Exeter (EU accredited), a top department in ecology and evolution worldwide, and under the supervision of two world leading scientists in their fields, will be crucial for the development of my career as an independent European researcher.

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The information about "ANTI-CRISPR" are provided by the European Opendata Portal: CORDIS opendata.

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