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ARCS SIGNED

Elucidating the gene exchange networks of antibiotic resistance genes in clinical sewage microbiomes

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ARCS project word cloud

Explore the words cloud of the ARCS project. It provides you a very rough idea of what is the project "ARCS" about.

ecosystem    lisandra    clinical    completion    amr    gene    birmingham    hosts    reveal    microbiomes    resistance    ensures    levels    sequencing    genes    assays    microbes    mentoring    willem    infections    prof    transfer    antibiotic    parties    realise    laboratory    genetic    capture    networks    leader    commensals    sources    successful    sewage    schaik    args    zepeda    ecosystems    hgt    pathogens    fellow    accomplishment    horizontal    shown    van    environment    wastewater    career    microbial    mobile    dr    throughput    link    diverse    international    generating    association    versa    data    promiscuous    university    microbiology    bacteria    analysing    pathogenic    gut    isolating    genomes    host    characterizing    human    clinically    culture    independent    deaths    bacterial    antibiotics    expertise    leadership    therapy    group    select    isolates    techniques    antimicrobial    skills    supportive    exchange    training    patients    spread    treating    vice    dna    conjugation    arcs   

Project "ARCS" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF BIRMINGHAM 

Organization address
address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT
website: www.bham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) coordinator 212˙933.00

Map

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Project objective

'Antibiotics are essential for treating bacterial infections. However, antimicrobial resistance (AMR) has spread among pathogenic bacteria, leading to therapy failure or deaths of patients. Due to their association with promiscuous mobile genetic elements, clinically important antibiotic resistance genes (ARGs) can spread rapidly among diverse bacteria through horizontal gene transfer (HGT). Due to HGT, identifying the microbial hosts of the ARGs in an ecosystem is a challenge. Importantly, it has been shown that ARGS can spread from human gut commensals to clinical pathogens and vice versa.

Wastewater from clinical sources can importantly select for HGT of ARGs between different microbes, as both antibiotics and ARGs are present at high levels. The aim of this project - 'ARCS' (Antibiotic Resistance in Clinical Sewage microbiomes), is to reveal the ARGs exchange networks in clinical sewage microbiomes. The research objectives are: 1) Link ARGs to microbial hosts by using novel culture-independent methods based on DNA high-throughput sequencing. 2) Link ARGs to mobile genetic elements by isolating, sequencing, and characterizing the genomes of the identified hosts of ARGs. 3) Evaluate whether the isolates can transfer their ARGs to clinical pathogens using conjugation assays. ARGS will thus lead to a step-change in our understanding of HGT of ARGs in complex microbial ecosystems.

The Fellow Dr. Lisandra Zepeda's expertise in generating and analysing DNA sequencing data and the host Prof. Willem van Schaik's international leadership in AMR ensure a successful completion of ARCS and a favourable knowledge transfer for both parties. Furthermore, the supportive environment of the University of Birmingham ensures the accomplishment of the Fellow's training in crucial areas such as microbial DNA capture sequencing, microbiology laboratory techniques, and mentoring skills. Thus, ARCS will enable Dr. Zepeda to realise her career goal of becoming a research group leader.'

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