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ARCS SIGNED

Elucidating the gene exchange networks of antibiotic resistance genes in clinical sewage microbiomes

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ARCS project word cloud

Explore the words cloud of the ARCS project. It provides you a very rough idea of what is the project "ARCS" about.

realise    arcs    hgt    van    microbes    group    career    levels    culture    wastewater    expertise    techniques    training    spread    analysing    association    successful    mobile    reveal    hosts    host    deaths    treating    zepeda    dna    university    patients    parties    promiscuous    sewage    microbial    willem    sequencing    international    pathogenic    shown    laboratory    prof    amr    ensures    clinical    therapy    bacteria    independent    leadership    link    skills    vice    birmingham    fellow    capture    environment    supportive    genomes    data    dr    completion    isolates    select    mentoring    clinically    args    exchange    gut    antibiotics    lisandra    genes    commensals    schaik    horizontal    ecosystems    transfer    isolating    antibiotic    microbiomes    gene    infections    pathogens    characterizing    human    conjugation    assays    bacterial    accomplishment    antimicrobial    sources    throughput    generating    leader    versa    ecosystem    diverse    genetic    microbiology    networks    resistance   

Project "ARCS" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF BIRMINGHAM 

Organization address
address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT
website: www.bham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2021-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) coordinator 212˙933.00

Map

 Project objective

'Antibiotics are essential for treating bacterial infections. However, antimicrobial resistance (AMR) has spread among pathogenic bacteria, leading to therapy failure or deaths of patients. Due to their association with promiscuous mobile genetic elements, clinically important antibiotic resistance genes (ARGs) can spread rapidly among diverse bacteria through horizontal gene transfer (HGT). Due to HGT, identifying the microbial hosts of the ARGs in an ecosystem is a challenge. Importantly, it has been shown that ARGS can spread from human gut commensals to clinical pathogens and vice versa.

Wastewater from clinical sources can importantly select for HGT of ARGs between different microbes, as both antibiotics and ARGs are present at high levels. The aim of this project - 'ARCS' (Antibiotic Resistance in Clinical Sewage microbiomes), is to reveal the ARGs exchange networks in clinical sewage microbiomes. The research objectives are: 1) Link ARGs to microbial hosts by using novel culture-independent methods based on DNA high-throughput sequencing. 2) Link ARGs to mobile genetic elements by isolating, sequencing, and characterizing the genomes of the identified hosts of ARGs. 3) Evaluate whether the isolates can transfer their ARGs to clinical pathogens using conjugation assays. ARGS will thus lead to a step-change in our understanding of HGT of ARGs in complex microbial ecosystems.

The Fellow Dr. Lisandra Zepeda's expertise in generating and analysing DNA sequencing data and the host Prof. Willem van Schaik's international leadership in AMR ensure a successful completion of ARCS and a favourable knowledge transfer for both parties. Furthermore, the supportive environment of the University of Birmingham ensures the accomplishment of the Fellow's training in crucial areas such as microbial DNA capture sequencing, microbiology laboratory techniques, and mentoring skills. Thus, ARCS will enable Dr. Zepeda to realise her career goal of becoming a research group leader.'

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The information about "ARCS" are provided by the European Opendata Portal: CORDIS opendata.

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