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Elucidating the gene exchange networks of antibiotic resistance genes in clinical sewage microbiomes

Total Cost €


EC-Contrib. €






 ARCS project word cloud

Explore the words cloud of the ARCS project. It provides you a very rough idea of what is the project "ARCS" about.

supportive    antibiotics    realise    university    leadership    therapy    isolating    human    van    environment    isolates    bacterial    shown    antimicrobial    gut    horizontal    vice    infections    versa    antibiotic    international    generating    lisandra    dna    group    bacteria    leader    zepeda    completion    wastewater    spread    schaik    pathogenic    prof    capture    skills    patients    conjugation    laboratory    hosts    ecosystem    career    host    ensures    microbiology    microbes    throughput    deaths    mentoring    parties    sequencing    args    diverse    hgt    birmingham    arcs    willem    genomes    mobile    amr    gene    sources    resistance    clinically    clinical    training    microbial    reveal    ecosystems    culture    pathogens    select    genetic    exchange    transfer    promiscuous    levels    characterizing    association    microbiomes    networks    analysing    successful    genes    fellow    independent    commensals    treating    dr    accomplishment    assays    link    techniques    sewage    data    expertise   

Project "ARCS" data sheet

The following table provides information about the project.


Organization address
address: Edgbaston
postcode: B15 2TT

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2021-07-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

'Antibiotics are essential for treating bacterial infections. However, antimicrobial resistance (AMR) has spread among pathogenic bacteria, leading to therapy failure or deaths of patients. Due to their association with promiscuous mobile genetic elements, clinically important antibiotic resistance genes (ARGs) can spread rapidly among diverse bacteria through horizontal gene transfer (HGT). Due to HGT, identifying the microbial hosts of the ARGs in an ecosystem is a challenge. Importantly, it has been shown that ARGS can spread from human gut commensals to clinical pathogens and vice versa.

Wastewater from clinical sources can importantly select for HGT of ARGs between different microbes, as both antibiotics and ARGs are present at high levels. The aim of this project - 'ARCS' (Antibiotic Resistance in Clinical Sewage microbiomes), is to reveal the ARGs exchange networks in clinical sewage microbiomes. The research objectives are: 1) Link ARGs to microbial hosts by using novel culture-independent methods based on DNA high-throughput sequencing. 2) Link ARGs to mobile genetic elements by isolating, sequencing, and characterizing the genomes of the identified hosts of ARGs. 3) Evaluate whether the isolates can transfer their ARGs to clinical pathogens using conjugation assays. ARGS will thus lead to a step-change in our understanding of HGT of ARGs in complex microbial ecosystems.

The Fellow Dr. Lisandra Zepeda's expertise in generating and analysing DNA sequencing data and the host Prof. Willem van Schaik's international leadership in AMR ensure a successful completion of ARCS and a favourable knowledge transfer for both parties. Furthermore, the supportive environment of the University of Birmingham ensures the accomplishment of the Fellow's training in crucial areas such as microbial DNA capture sequencing, microbiology laboratory techniques, and mentoring skills. Thus, ARCS will enable Dr. Zepeda to realise her career goal of becoming a research group leader.'

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The information about "ARCS" are provided by the European Opendata Portal: CORDIS opendata.

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