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signalling dynamics SIGNED

Bridging biophysics and cell biology: The role of G protein-coupled receptor conformations in signalling

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "signalling dynamics" data sheet

The following table provides information about the project.

Coordinator
UNITED KINGDOM RESEARCH AND INNOVATION 

Organization address
address: POLARIS HOUSE NORTH STAR AVENUE
city: SWINDON
postcode: SN2 1FL
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 271˙732 €
 EC max contribution 271˙732 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-GF
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNITED KINGDOM RESEARCH AND INNOVATION UK (SWINDON) coordinator 271˙732.00
2    BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY US (STANFORD) partner 0.00

Map

 Project objective

G protein coupled receptors (GPCRs) are a class of membrane receptors that transmits extracellular signals into the cell. They can be activated by a diverse set of ligands including small molecules, hormones, neurotransmitters or photons and are targeted by a third of currently marketed drugs. Endogenous ligands and drugs may exhibit different efficacy profiles, ranging from full activation to complete inactivation of a signalling pathway. The key to the selective interaction with signalling partners in response to ligand binding lies in the conformational flexibility of the membrane receptors. Previous research has extensively studied the three-dimensional structures of GPCRs and their signalling. However, the link between active conformations and signalling is still missing. In the proposed project, first I will use exhaustive single-point mutagenesis coupled to functional assays to determine how the sequence and secondary structure of GPCRs contribute to signaling. Second, biophysical techniques studying protein conformations will help us to understand the connection between conformations and signalling outcome. These techniques give insights into the conformational fingerprints of the receptor. The link to signalling will be achieved by biasing the receptor towards a selected signalling partner either though addition of the selected signalling partner or the insertion of specific mutations tested in the first part of the project. Finally, I will use computational techniques to compare the activation of signalling partners in different GPCRs. With my research I hope to improve our understanding of the molecular basis of membrane protein function and contribute to the development of strategies for the design of more specific drugs with fewer side effects.

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The information about "SIGNALLING DYNAMICS" are provided by the European Opendata Portal: CORDIS opendata.

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