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F4TGLUT TERMINATED

Food for thought: monitoring the effects of drugs and diet on neuronal glutamate release using nanoelectrodes

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 F4TGLUT project word cloud

Explore the words cloud of the F4TGLUT project. It provides you a very rough idea of what is the project "F4TGLUT" about.

memory    underlies    chemical    imaging    signaling    extensive    cells    guidance    disease    modulates    innervated    precise    plasticity    miniaturized    agents    triggers    drug    levels    unprecedented    exposure    phenomenon    activating    release    microfluidics    adjacent    pharmacy    dietary    transmission    sensors    individual    additionally    monitor    glutamate    microfluidic    brain    underlie    neurotransmitter    fundamental    nanoliter    precisely    fluids    direct    microstructures    placement    experiments    therapeutic    alzheimer    cell    occurs    supplemented    combines    cellular    synaptic    device    plays    combination    neurotransmission    will    platform    significantly    equipped    signal    uniquely    neurons    urge    primary    ideal    diet    spatiotemporal    cultured    compounds    analytical    pathological    sensitive    nanoelectrodes    drugs    create    host    monitoring    influence    fabricated    selective    culture    synapse    resolution    vitro    expertise   

Project "F4TGLUT" data sheet

The following table provides information about the project.

Coordinator
GOETEBORGS UNIVERSITET 

Organization address
address: VASAPARKEN
city: GOETEBORG
postcode: 405 30
website: www.gu.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 191˙852 €
 EC max contribution 191˙852 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    GOETEBORGS UNIVERSITET SE (GOETEBORG) coordinator 191˙852.00

Map

 Project objective

Glutamate is the primary activating neurotransmitter in the brain. It modulates synaptic plasticity of neurons, which underlies memory formation. However, it also plays a fundamental role in pathological processes, such as those related to Alzheimer’s disease. This essential role and future development of therapeutic agents urge the development of a highly-sensitive analytical method for determining glutamate levels at a cellular level. In this project I will create a miniaturized, in vitro system that will allow this. To develop it, my expertise in microfluidics and pharmacy will be supplemented by the host’s extensive experience with cell analysis and nanoelectrodes.

When glutamate-type neurons in the brain are innervated, glutamate release into the synapse between adjacent neurons occurs. This triggers chemical signal transmission. Nanoelectrodes are uniquely equipped to monitor this neurotransmitter release with unprecedented spatiotemporal resolution. The combination with microfluidics will allow control of fluids and experiments at the nanoliter scale. Furthermore, through precisely fabricated microstructures, guidance of cell growth and precise placement of the nanoelectrodes in the device will be achieved.

Glutamate modulates synaptic plasticity, a phenomenon understood to underlie memory formation. Furthermore, dietary compounds and drugs can influence glutamate neurotransmission. The proposed system enables selective exposure of individual neurons cultured in the microfluidic device to such compounds. Using the integrated nanoelectrodes, direct monitoring of their effects on chemical signaling between cells will be possible. The results will significantly contribute to our understanding of glutamate neurotransmission, and how drugs and diet can influence it. Additionally, the system combines cell culture, selective exposure and analyses at the cellular level using sensors and imaging, making it an ideal platform for future drug development research.

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The information about "F4TGLUT" are provided by the European Opendata Portal: CORDIS opendata.

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