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F4TGLUT TERMINATED

Food for thought: monitoring the effects of drugs and diet on neuronal glutamate release using nanoelectrodes

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 F4TGLUT project word cloud

Explore the words cloud of the F4TGLUT project. It provides you a very rough idea of what is the project "F4TGLUT" about.

selective    disease    fundamental    synaptic    exposure    memory    modulates    significantly    unprecedented    drugs    precise    cultured    additionally    levels    placement    monitoring    resolution    occurs    analytical    vitro    urge    fabricated    dietary    imaging    cells    activating    spatiotemporal    supplemented    combination    will    sensors    neurotransmission    phenomenon    neurotransmitter    plays    therapeutic    miniaturized    equipped    microfluidic    uniquely    cell    experiments    plasticity    precisely    diet    individual    glutamate    underlies    combines    compounds    agents    expertise    sensitive    device    triggers    pharmacy    neurons    brain    cellular    guidance    direct    create    nanoelectrodes    nanoliter    extensive    fluids    synapse    alzheimer    signaling    influence    adjacent    host    signal    monitor    microstructures    transmission    primary    underlie    platform    pathological    chemical    release    drug    ideal    culture    innervated    microfluidics   

Project "F4TGLUT" data sheet

The following table provides information about the project.

Coordinator
GOETEBORGS UNIVERSITET 

Organization address
address: VASAPARKEN
city: GOETEBORG
postcode: 405 30
website: www.gu.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 191˙852 €
 EC max contribution 191˙852 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    GOETEBORGS UNIVERSITET SE (GOETEBORG) coordinator 191˙852.00

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 Project objective

Glutamate is the primary activating neurotransmitter in the brain. It modulates synaptic plasticity of neurons, which underlies memory formation. However, it also plays a fundamental role in pathological processes, such as those related to Alzheimer’s disease. This essential role and future development of therapeutic agents urge the development of a highly-sensitive analytical method for determining glutamate levels at a cellular level. In this project I will create a miniaturized, in vitro system that will allow this. To develop it, my expertise in microfluidics and pharmacy will be supplemented by the host’s extensive experience with cell analysis and nanoelectrodes.

When glutamate-type neurons in the brain are innervated, glutamate release into the synapse between adjacent neurons occurs. This triggers chemical signal transmission. Nanoelectrodes are uniquely equipped to monitor this neurotransmitter release with unprecedented spatiotemporal resolution. The combination with microfluidics will allow control of fluids and experiments at the nanoliter scale. Furthermore, through precisely fabricated microstructures, guidance of cell growth and precise placement of the nanoelectrodes in the device will be achieved.

Glutamate modulates synaptic plasticity, a phenomenon understood to underlie memory formation. Furthermore, dietary compounds and drugs can influence glutamate neurotransmission. The proposed system enables selective exposure of individual neurons cultured in the microfluidic device to such compounds. Using the integrated nanoelectrodes, direct monitoring of their effects on chemical signaling between cells will be possible. The results will significantly contribute to our understanding of glutamate neurotransmission, and how drugs and diet can influence it. Additionally, the system combines cell culture, selective exposure and analyses at the cellular level using sensors and imaging, making it an ideal platform for future drug development research.

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The information about "F4TGLUT" are provided by the European Opendata Portal: CORDIS opendata.

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