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Bi-directional Force Communication on Cell-Matrix

Total Cost €


EC-Contrib. €






 BiFCCM project word cloud

Explore the words cloud of the BiFCCM project. It provides you a very rough idea of what is the project "BiFCCM" about.

porous    tension    gels    resolution    first    gel    biomaterials    transfer    marie    excellent    fellowships    pic    tunable    tailor    remodel    sk    proteomic    bi    turn    combine    behavior    spatial    ecms    cells    action    interact    fa    quantified    ku    effect    odowska    independently    majority    focal    mission    difficult    mimic    adhesions    ecm    mechanobiology    external    microscopic    individual    relevance    radboud    traction    generate    curie    sense    stiffen    nijmegen    poorly    extracellular    forces    proteome    polyisocyanide    sensor    complexes    exchange    size    performed    nonlinear    super    contractile    proteomics    cellular    leuven    single    lack    molecular    microscope    fret    network    finished    microenvironment    prospects    natural    career    university    synthetic    functionalization    protein    mostly    techniques    architecture    tfm    matrix    force    gain    stiffening    mechanical    matches    functions    material    mechanics    imaging    fas    biological    directional    phd    expertise    cell    link   

Project "BiFCCM" data sheet

The following table provides information about the project.


Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 178˙320 €
 EC max contribution 178˙320 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2021-10-13


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Cells continuously sense external forces from their microenvironment, the extracellular matrix (ECM). In turn, they generate contractile forces, which stiffen and remodel this matrix. Although this bi-directional mechanical exchange is crucial for many cell functions, is remains poorly understood, mostly since the majority of ECMs, both natural and synthetic, are difficult to control or lack biological relevance. A new synthetic polyisocyanide (PIC) gel is the first material that is an excellent mimic of the ECM (porous network architecture and nonlinear mechanics, including stiffening) and can independently tailor mechanical and biological properties. The gel is developed at Radboud University Nijmegen, where I finished my PhD. In this action, I want to study how forces from the cell or the ECM change the mechanical properties of the matrix and, more importantly, how this change affects biological functions. To this end, I will combine the unique, highly tunable PIC gels as synthetic ECM and study the matrix and cell behavior using advanced microscopic imaging techniques and spatial proteomics. Through PIC functionalization, I can tailor the size and number of focal adhesions (FAs), i.e. the protein complexes that link cells to the ECM. The forces generated by cells will be quantified both on cellular and single FA level by traction force microscope (TFM) and molecular tension sensor-based FRET. In addition, proteomic analysis will be performed to evaluate the effect of gels with different mechanical properties in the proteome. These results will have a high impact for understanding how cells interact with matrix through forces. Beyond my knowledge in biomaterials, I will gain new expertise in super-resolution microscope and mechanobiology at KU Leuven. This project highly matches the mission of the Marie Skłodowska-Curie Individual Fellowships to achieve two-way knowledge transfer and to promote my future career prospects.

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The information about "BIFCCM" are provided by the European Opendata Portal: CORDIS opendata.

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