Opendata, web and dolomites


Bi-directional Force Communication on Cell-Matrix

Total Cost €


EC-Contrib. €






 BiFCCM project word cloud

Explore the words cloud of the BiFCCM project. It provides you a very rough idea of what is the project "BiFCCM" about.

excellent    ecm    focal    proteomics    proteomic    tfm    gel    poorly    imaging    performed    ku    mimic    finished    matrix    prospects    microscopic    nijmegen    majority    career    first    fa    action    difficult    behavior    expertise    functions    fret    stiffening    cell    tension    microenvironment    biomaterials    protein    external    extracellular    super    leuven    fas    university    mechanics    mechanical    phd    force    nonlinear    matches    odowska    quantified    network    individual    synthetic    single    interact    sk    size    effect    techniques    adhesions    architecture    directional    marie    tunable    turn    forces    microscope    mission    curie    material    remodel    gels    pic    independently    mostly    radboud    link    tailor    stiffen    combine    ecms    complexes    gain    porous    traction    relevance    transfer    molecular    mechanobiology    sense    contractile    functionalization    cells    bi    polyisocyanide    biological    sensor    cellular    proteome    exchange    spatial    lack    natural    fellowships    resolution    generate   

Project "BiFCCM" data sheet

The following table provides information about the project.


Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 178˙320 €
 EC max contribution 178˙320 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2021-10-13


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Cells continuously sense external forces from their microenvironment, the extracellular matrix (ECM). In turn, they generate contractile forces, which stiffen and remodel this matrix. Although this bi-directional mechanical exchange is crucial for many cell functions, is remains poorly understood, mostly since the majority of ECMs, both natural and synthetic, are difficult to control or lack biological relevance. A new synthetic polyisocyanide (PIC) gel is the first material that is an excellent mimic of the ECM (porous network architecture and nonlinear mechanics, including stiffening) and can independently tailor mechanical and biological properties. The gel is developed at Radboud University Nijmegen, where I finished my PhD. In this action, I want to study how forces from the cell or the ECM change the mechanical properties of the matrix and, more importantly, how this change affects biological functions. To this end, I will combine the unique, highly tunable PIC gels as synthetic ECM and study the matrix and cell behavior using advanced microscopic imaging techniques and spatial proteomics. Through PIC functionalization, I can tailor the size and number of focal adhesions (FAs), i.e. the protein complexes that link cells to the ECM. The forces generated by cells will be quantified both on cellular and single FA level by traction force microscope (TFM) and molecular tension sensor-based FRET. In addition, proteomic analysis will be performed to evaluate the effect of gels with different mechanical properties in the proteome. These results will have a high impact for understanding how cells interact with matrix through forces. Beyond my knowledge in biomaterials, I will gain new expertise in super-resolution microscope and mechanobiology at KU Leuven. This project highly matches the mission of the Marie Skłodowska-Curie Individual Fellowships to achieve two-way knowledge transfer and to promote my future career prospects.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "BIFCCM" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "BIFCCM" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

EPIC (2019)

Evolution of Planktonic Gastropod Calcification

Read More  

GenEl (2020)

General readout electronics for cross-sectoral application in European research infrastructure

Read More  

NPsVLCD (2019)

Natural Product-Inspired Therapies for Leishmaniasis and Chagas Disease

Read More