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BiFCCM SIGNED

Bi-directional Force Communication on Cell-Matrix

Total Cost €

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EC-Contrib. €

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Partnership

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 BiFCCM project word cloud

Explore the words cloud of the BiFCCM project. It provides you a very rough idea of what is the project "BiFCCM" about.

mechanics    gel    radboud    external    stiffening    university    traction    mimic    focal    techniques    difficult    lack    mostly    quantified    turn    link    matrix    fa    mission    action    excellent    effect    remodel    tailor    career    curie    exchange    sensor    microenvironment    nijmegen    combine    performed    forces    proteome    transfer    contractile    porous    marie    resolution    microscope    imaging    functions    gain    super    leuven    mechanical    tfm    ku    spatial    matches    material    biomaterials    nonlinear    relevance    size    single    fret    stiffen    fas    adhesions    functionalization    extracellular    polyisocyanide    architecture    complexes    gels    behavior    ecm    proteomics    generate    microscopic    odowska    pic    prospects    biological    cell    poorly    individual    expertise    tunable    network    protein    mechanobiology    sense    independently    synthetic    proteomic    sk    natural    phd    bi    finished    cellular    directional    interact    majority    force    first    cells    fellowships    ecms    tension    molecular   

Project "BiFCCM" data sheet

The following table provides information about the project.

Coordinator
KATHOLIEKE UNIVERSITEIT LEUVEN 

Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000
website: www.kuleuven.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 178˙320 €
 EC max contribution 178˙320 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2021-10-13

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) coordinator 178˙320.00

Map

 Project objective

Cells continuously sense external forces from their microenvironment, the extracellular matrix (ECM). In turn, they generate contractile forces, which stiffen and remodel this matrix. Although this bi-directional mechanical exchange is crucial for many cell functions, is remains poorly understood, mostly since the majority of ECMs, both natural and synthetic, are difficult to control or lack biological relevance. A new synthetic polyisocyanide (PIC) gel is the first material that is an excellent mimic of the ECM (porous network architecture and nonlinear mechanics, including stiffening) and can independently tailor mechanical and biological properties. The gel is developed at Radboud University Nijmegen, where I finished my PhD. In this action, I want to study how forces from the cell or the ECM change the mechanical properties of the matrix and, more importantly, how this change affects biological functions. To this end, I will combine the unique, highly tunable PIC gels as synthetic ECM and study the matrix and cell behavior using advanced microscopic imaging techniques and spatial proteomics. Through PIC functionalization, I can tailor the size and number of focal adhesions (FAs), i.e. the protein complexes that link cells to the ECM. The forces generated by cells will be quantified both on cellular and single FA level by traction force microscope (TFM) and molecular tension sensor-based FRET. In addition, proteomic analysis will be performed to evaluate the effect of gels with different mechanical properties in the proteome. These results will have a high impact for understanding how cells interact with matrix through forces. Beyond my knowledge in biomaterials, I will gain new expertise in super-resolution microscope and mechanobiology at KU Leuven. This project highly matches the mission of the Marie Skłodowska-Curie Individual Fellowships to achieve two-way knowledge transfer and to promote my future career prospects.

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The information about "BIFCCM" are provided by the European Opendata Portal: CORDIS opendata.

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