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BiFCCM SIGNED

Bi-directional Force Communication on Cell-Matrix

Total Cost €

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EC-Contrib. €

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Partnership

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 BiFCCM project word cloud

Explore the words cloud of the BiFCCM project. It provides you a very rough idea of what is the project "BiFCCM" about.

tailor    proteomics    directional    transfer    link    sensor    performed    focal    complexes    fas    molecular    poorly    synthetic    natural    network    polyisocyanide    odowska    tension    matrix    quantified    extracellular    mechanics    turn    difficult    marie    sk    stiffening    gels    exchange    mostly    size    imaging    proteome    biological    lack    bi    cell    mechanobiology    ecms    resolution    single    generate    fellowships    effect    mimic    fret    independently    pic    interact    action    architecture    mission    finished    proteomic    fa    microscopic    nijmegen    adhesions    biomaterials    porous    contractile    cells    radboud    super    matches    phd    expertise    external    curie    prospects    traction    first    microenvironment    material    excellent    mechanical    leuven    university    individual    protein    remodel    gain    gel    behavior    stiffen    majority    nonlinear    combine    functions    career    spatial    sense    tfm    forces    cellular    relevance    tunable    techniques    force    microscope    ku    functionalization    ecm   

Project "BiFCCM" data sheet

The following table provides information about the project.

Coordinator
KATHOLIEKE UNIVERSITEIT LEUVEN 

Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000
website: www.kuleuven.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 178˙320 €
 EC max contribution 178˙320 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-10-01   to  2021-10-13

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) coordinator 178˙320.00

Map

 Project objective

Cells continuously sense external forces from their microenvironment, the extracellular matrix (ECM). In turn, they generate contractile forces, which stiffen and remodel this matrix. Although this bi-directional mechanical exchange is crucial for many cell functions, is remains poorly understood, mostly since the majority of ECMs, both natural and synthetic, are difficult to control or lack biological relevance. A new synthetic polyisocyanide (PIC) gel is the first material that is an excellent mimic of the ECM (porous network architecture and nonlinear mechanics, including stiffening) and can independently tailor mechanical and biological properties. The gel is developed at Radboud University Nijmegen, where I finished my PhD. In this action, I want to study how forces from the cell or the ECM change the mechanical properties of the matrix and, more importantly, how this change affects biological functions. To this end, I will combine the unique, highly tunable PIC gels as synthetic ECM and study the matrix and cell behavior using advanced microscopic imaging techniques and spatial proteomics. Through PIC functionalization, I can tailor the size and number of focal adhesions (FAs), i.e. the protein complexes that link cells to the ECM. The forces generated by cells will be quantified both on cellular and single FA level by traction force microscope (TFM) and molecular tension sensor-based FRET. In addition, proteomic analysis will be performed to evaluate the effect of gels with different mechanical properties in the proteome. These results will have a high impact for understanding how cells interact with matrix through forces. Beyond my knowledge in biomaterials, I will gain new expertise in super-resolution microscope and mechanobiology at KU Leuven. This project highly matches the mission of the Marie Skłodowska-Curie Individual Fellowships to achieve two-way knowledge transfer and to promote my future career prospects.

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The information about "BIFCCM" are provided by the European Opendata Portal: CORDIS opendata.

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