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PeriGO SIGNED

Peripheral nerve Gel-based Orientation (Peripheral nerve injury recovery using Gel-based Orientation)

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 PeriGO project word cloud

Explore the words cloud of the PeriGO project. It provides you a very rough idea of what is the project "PeriGO" about.

blood    inside    artificial    hospital    erc    laboratory    defect    injuries    direct    pave    smart    bridging    handling    clinic    adjusting    adapt    overcome    business    aachen    good    model    gap    nerve    translation    tight    absent    lesion    actions    strategies    creates    hydrogel    packaging    injected    strategy    final    vessel    regenerating    secondary    university    commercialization    cord    plastic    biocompatible    initially    stumps    autologous    gaps    peripheral    unidirectional    injury    contact    perigo    interface    cooperation    site    damaged    platform    superior    tube    reconnect    marginal    uses    perform    tubes    material    tests    hollow    generation    cm    gelation    rat    verify    standard    surgery    gold    kinetics    degradation    sterilization    nerves    sophisticated    quick    tunable    sciatic    grafts    repair    length    provides    commercially    limitations    shape    efficacy    clinical    first    implantation    injured    alternative    structures    complete    anisogel    injectable    directionality    lt    plan    regeneration    liquid    distances    guiding    spinal    market   

Project "PeriGO" data sheet

The following table provides information about the project.

Coordinator
DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV 

Organization address
address: FORCKENBECKSTRASSE 50
city: AACHEN
postcode: 52074
website: www.dwi.rwth-aachen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-PoC
 Funding Scheme ERC-POC
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2021-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV DE (AACHEN) coordinator 120˙000.00
2    UNIVERSITAETSKLINIKUM AACHEN DE (AACHEN) participant 30˙000.00

Map

 Project objective

PeriGO will pave the way for the commercialization of a unique, first-of-its-kind peripheral nerve repair strategy, as it uses an injectable, biocompatible hydrogel that provides directionality through controlled guiding elements. The properties of the smart material Anisogel, initially developed in the ERC project ANISOGEL to repair spinal cord injuries, provide a sophisticated, superior alternative for peripheral nerve regeneration. The final product can be injected inside a bridging blood vessel or artificial hollow tube after implantation to direct regenerating nerves across the injury site. PeriGO comprises 3 key actions to advance a quick translation from the laboratory to the clinic: We will 1) establish a sterilization method and a packaging/application system to perform pre-clinical tests, 2) verify the handling and efficacy of the product in a rat sciatic nerve lesion model in cooperation with the Department of Plastic Surgery at the University Hospital in Aachen, and 3) complete a market study and business plan to bring PeriGO into the clinic. PeriGO addresses essential issues associated with peripheral nerve regeneration. While the current Gold Standard of autologous nerve grafts creates a secondary defect, artificial bridging approaches for nerve gaps only reconnect short distances (< 3 cm) with marginal success. Features absent in the commercially available nerve tubes are guiding structures, controlled degradation, and a good interface with the damaged nerve stumps. The PeriGO platform will overcome these limitations as the material 1) is injected as a liquid to make a tight contact with the injured nerve and to adapt to the shape of the bridging tube before gelation, 2) provides unidirectional guiding elements, and 3) presents tunable material properties with tunable degradation kinetics adjusting to the length of the nerve gap. With PeriGO, we will thus establish the next generation of nerve repair strategies.

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The information about "PERIGO" are provided by the European Opendata Portal: CORDIS opendata.

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