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PeriGO SIGNED

Peripheral nerve Gel-based Orientation (Peripheral nerve injury recovery using Gel-based Orientation)

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 PeriGO project word cloud

Explore the words cloud of the PeriGO project. It provides you a very rough idea of what is the project "PeriGO" about.

surgery    uses    plastic    injury    damaged    interface    translation    peripheral    quick    gaps    limitations    vessel    hollow    complete    aachen    degradation    commercialization    plan    efficacy    business    kinetics    structures    implantation    adjusting    cooperation    hospital    shape    hydrogel    reconnect    provides    clinical    alternative    biocompatible    site    sophisticated    sterilization    nerves    direct    directionality    spinal    platform    strategy    tests    perigo    model    overcome    stumps    initially    tight    superior    injectable    bridging    anisogel    nerve    inside    cord    distances    regenerating    regeneration    injured    strategies    gelation    injuries    repair    unidirectional    perform    actions    market    rat    defect    artificial    length    standard    verify    commercially    liquid    packaging    absent    first    material    lt    tube    lesion    gap    gold    creates    university    good    adapt    tunable    smart    marginal    blood    guiding    handling    laboratory    contact    final    generation    autologous    sciatic    cm    tubes    injected    secondary    clinic    grafts    pave    erc   

Project "PeriGO" data sheet

The following table provides information about the project.

Coordinator
DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV 

Organization address
address: FORCKENBECKSTRASSE 50
city: AACHEN
postcode: 52074
website: www.dwi.rwth-aachen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-PoC
 Funding Scheme ERC-POC
 Starting year 2019
 Duration (year-month-day) from 2019-08-01   to  2021-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV DE (AACHEN) coordinator 120˙000.00
2    UNIVERSITAETSKLINIKUM AACHEN DE (AACHEN) participant 30˙000.00

Map

 Project objective

PeriGO will pave the way for the commercialization of a unique, first-of-its-kind peripheral nerve repair strategy, as it uses an injectable, biocompatible hydrogel that provides directionality through controlled guiding elements. The properties of the smart material Anisogel, initially developed in the ERC project ANISOGEL to repair spinal cord injuries, provide a sophisticated, superior alternative for peripheral nerve regeneration. The final product can be injected inside a bridging blood vessel or artificial hollow tube after implantation to direct regenerating nerves across the injury site. PeriGO comprises 3 key actions to advance a quick translation from the laboratory to the clinic: We will 1) establish a sterilization method and a packaging/application system to perform pre-clinical tests, 2) verify the handling and efficacy of the product in a rat sciatic nerve lesion model in cooperation with the Department of Plastic Surgery at the University Hospital in Aachen, and 3) complete a market study and business plan to bring PeriGO into the clinic. PeriGO addresses essential issues associated with peripheral nerve regeneration. While the current Gold Standard of autologous nerve grafts creates a secondary defect, artificial bridging approaches for nerve gaps only reconnect short distances (< 3 cm) with marginal success. Features absent in the commercially available nerve tubes are guiding structures, controlled degradation, and a good interface with the damaged nerve stumps. The PeriGO platform will overcome these limitations as the material 1) is injected as a liquid to make a tight contact with the injured nerve and to adapt to the shape of the bridging tube before gelation, 2) provides unidirectional guiding elements, and 3) presents tunable material properties with tunable degradation kinetics adjusting to the length of the nerve gap. With PeriGO, we will thus establish the next generation of nerve repair strategies.

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The information about "PERIGO" are provided by the European Opendata Portal: CORDIS opendata.

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