Opendata, web and dolomites

MalusEdit SIGNED

Malus genome editing via CRISPR/Cas9 to develop sustainable pest free apples

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

Project "MalusEdit" data sheet

The following table provides information about the project.

Coordinator
FONDAZIONE EDMUND MACH 

Organization address
address: VIA EDMONDO MACH 1
city: SAN MICHELE ALL'ADIGE
postcode: 38010
website: http://cri.fmach.eu; www.fmach.eu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 183˙473 €
 EC max contribution 183˙473 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-10-16   to  2021-10-15

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE EDMUND MACH IT (SAN MICHELE ALL'ADIGE) coordinator 183˙473.00

Map

 Project objective

Apple is one of the most important crop. Pathogens causing powdery mildew, fire blight, and scab represent serious threats to apple cultivation. These pathogens are mainly controlled by pesticides with a negative impact on the environment and possibly on the health of the consumers on the long term. Resistant cultivars are the most effective and sustainable means to control these threats. Resistance to pathogens is usually conferred to apples by the introgression of R-genes from wild cultivars but such approach is not durable. Suppression of genes used by pathogens for infection (S-genes) can reduce pathogen attack. CRISPR/Cas9-mediated genome editing was used to mutate S-genes but these attempts were limited to single genes and were based on the stable integration of the editing machinery preventing these plants from being accepted by customers. The main objective of this project is to use CRISPR/Cas9 to create a multi-resistant apple variety by the simultaneous mutation of S-genes which are responsible for susceptibility to powdery mildew and fire blight. The main challenge will be to introduce such mutations using a “transgene-free” approach which is not based on protoplast transformation. The innovative approach consists on delivering the editing machinery via Agrobacterium tumefaciens or particle bombardment to apple cells and then eliminate editing components after mutation using an inducible site-specific recombination-based system. The final goal is to obtain a multi-resistant, sustainable and transgene-free apple. The second objective of the project is to develop a method for regeneration of apple plants from protoplast which safeguard genetic stability during regeneration to allow genome editing in apple protoplasts using pre-assembled Cas9-sgRNA ribonucleoproteins.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MALUSEDIT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MALUSEDIT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

MarshFlux (2020)

The effect of future global climate and land-use change on greenhouse gas fluxes and microbial processes in salt marshes

Read More  

BirthControlEnvirons (2019)

Contraception meets the environment: everyday contraceptive practices, politics, and futures in a toxic age

Read More  

MIGPSC (2018)

Shaping the European Migration Policy: the role of the security industry

Read More