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SynGut SIGNED

Molecular, morphological, and functional requirements for gastrointestinal serotonin release

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SynGut project word cloud

Explore the words cloud of the SynGut project. It provides you a very rough idea of what is the project "SynGut" about.

communication    disorders    secreting    morphological    function    ens    chemoreceptors    secretion    molecular    critical    microscopy    tract    reminiscent    answer    hormone    difficult    intestinal    diabetes    gi    notably    me    eecs    ec    treating    obesity    3d    gastro    mechanisms    regulating    question    implicated    brain    plays    release    bowel    electron    cell    correlative    pain    signal    rna    sequencing    mechano    date    impairments    heart    cultures    functional    density    synapses    nervous    accordingly    intriguing    synapse    lie    enteric    circuits    multiple    local    neuronal    context    connections    enteroendocrine    light    strikingly    mediate    diseases    fundamental    synaptic    form    pathogenesis    organoid    enterochromaffin    hypothesis    poorly    contacts    electrophysiology    combining    signalling    cells    overview    serotonin    multidisciplinary    group    mechanism    inflammatory    cellular    visceral    questions    single    gut    spatial   

Project "SynGut" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 207˙312 €
 EC max contribution 207˙312 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 207˙312.00

Map

 Project objective

Communication between the gastro-intestinal (GI) tract, the enteric nervous system (ENS), and the brain plays an important role in regulating our behaviour, and accordingly, impairments in this communication have been implicated in the pathogenesis of multiple disorders including obesity, diabetes, visceral pain, and inflammatory bowel diseases. A better understanding of the molecular and cellular mechanisms of gut-to-brain signalling will be critical for treating these disorders. An important group of cells in this context are enteroendocrine cells (EECs), and most notably enterochromaffin (EC) cells, which function as mechano- and chemoreceptors and signal by secreting serotonin, however the release process is poorly understood. Strikingly, these cells show molecular and morphological features that are highly reminiscent of neuronal synapses in the brain, raising the intriguing hypothesis that they may form synapse-like contacts that lie at the heart of their communication mechanism. To date, however, this hypothesis has been difficult to test due to the low spatial density of EC cells along the GI tract. Using a multidisciplinary approach combining intestinal 3D-organoid cultures, correlative light- and electron microscopy, electrophysiology, and single-cell RNA sequencing, this project aims to address the questions i) which molecular mechanisms mediate hormone secretion from EC cells, ii) what are the functional properties of the release process, and iii) how are local circuits organized to signal information to the ENS and brain. The results from this study will allow me to answer the fundamental question whether EC cells form functional synaptic connections, as well as providing a comprehensive overview over the functional and molecular properties of these ‘synapses’.

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The information about "SYNGUT" are provided by the European Opendata Portal: CORDIS opendata.

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