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SynGut SIGNED

Molecular, morphological, and functional requirements for gastrointestinal serotonin release

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SynGut project word cloud

Explore the words cloud of the SynGut project. It provides you a very rough idea of what is the project "SynGut" about.

mechanism    me    eecs    gastro    diseases    3d    critical    combining    spatial    rna    intriguing    regulating    bowel    diabetes    signal    fundamental    difficult    hypothesis    molecular    organoid    cell    single    mediate    disorders    gi    morphological    implicated    ec    chemoreceptors    synaptic    sequencing    tract    mechanisms    circuits    ens    enterochromaffin    intestinal    reminiscent    inflammatory    enteric    pathogenesis    date    release    signalling    visceral    contacts    cellular    serotonin    electrophysiology    synapse    connections    question    multiple    correlative    lie    cultures    form    synapses    electron    cells    multidisciplinary    overview    local    impairments    obesity    answer    enteroendocrine    notably    light    questions    context    secreting    accordingly    hormone    plays    treating    heart    poorly    functional    microscopy    nervous    gut    density    secretion    strikingly    pain    neuronal    brain    function    communication    group    mechano   

Project "SynGut" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 207˙312 €
 EC max contribution 207˙312 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 207˙312.00

Map

 Project objective

Communication between the gastro-intestinal (GI) tract, the enteric nervous system (ENS), and the brain plays an important role in regulating our behaviour, and accordingly, impairments in this communication have been implicated in the pathogenesis of multiple disorders including obesity, diabetes, visceral pain, and inflammatory bowel diseases. A better understanding of the molecular and cellular mechanisms of gut-to-brain signalling will be critical for treating these disorders. An important group of cells in this context are enteroendocrine cells (EECs), and most notably enterochromaffin (EC) cells, which function as mechano- and chemoreceptors and signal by secreting serotonin, however the release process is poorly understood. Strikingly, these cells show molecular and morphological features that are highly reminiscent of neuronal synapses in the brain, raising the intriguing hypothesis that they may form synapse-like contacts that lie at the heart of their communication mechanism. To date, however, this hypothesis has been difficult to test due to the low spatial density of EC cells along the GI tract. Using a multidisciplinary approach combining intestinal 3D-organoid cultures, correlative light- and electron microscopy, electrophysiology, and single-cell RNA sequencing, this project aims to address the questions i) which molecular mechanisms mediate hormone secretion from EC cells, ii) what are the functional properties of the release process, and iii) how are local circuits organized to signal information to the ENS and brain. The results from this study will allow me to answer the fundamental question whether EC cells form functional synaptic connections, as well as providing a comprehensive overview over the functional and molecular properties of these ‘synapses’.

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The information about "SYNGUT" are provided by the European Opendata Portal: CORDIS opendata.

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