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SynGut SIGNED

Molecular, morphological, and functional requirements for gastrointestinal serotonin release

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SynGut project word cloud

Explore the words cloud of the SynGut project. It provides you a very rough idea of what is the project "SynGut" about.

lie    signal    gi    3d    light    secretion    release    ec    rna    intestinal    pain    bowel    functional    date    combining    plays    circuits    pathogenesis    questions    gastro    group    difficult    poorly    fundamental    heart    mediate    serotonin    enteric    ens    neuronal    chemoreceptors    notably    organoid    regulating    overview    strikingly    cellular    eecs    brain    microscopy    me    connections    critical    spatial    hypothesis    multidisciplinary    synapses    electrophysiology    morphological    hormone    implicated    mechanisms    sequencing    contacts    communication    synaptic    mechanism    secreting    disorders    intriguing    tract    enterochromaffin    cells    correlative    inflammatory    cell    enteroendocrine    nervous    multiple    form    density    electron    context    gut    local    synapse    function    impairments    accordingly    visceral    obesity    question    diabetes    mechano    reminiscent    treating    signalling    cultures    answer    molecular    diseases    single   

Project "SynGut" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 207˙312 €
 EC max contribution 207˙312 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 207˙312.00

Map

 Project objective

Communication between the gastro-intestinal (GI) tract, the enteric nervous system (ENS), and the brain plays an important role in regulating our behaviour, and accordingly, impairments in this communication have been implicated in the pathogenesis of multiple disorders including obesity, diabetes, visceral pain, and inflammatory bowel diseases. A better understanding of the molecular and cellular mechanisms of gut-to-brain signalling will be critical for treating these disorders. An important group of cells in this context are enteroendocrine cells (EECs), and most notably enterochromaffin (EC) cells, which function as mechano- and chemoreceptors and signal by secreting serotonin, however the release process is poorly understood. Strikingly, these cells show molecular and morphological features that are highly reminiscent of neuronal synapses in the brain, raising the intriguing hypothesis that they may form synapse-like contacts that lie at the heart of their communication mechanism. To date, however, this hypothesis has been difficult to test due to the low spatial density of EC cells along the GI tract. Using a multidisciplinary approach combining intestinal 3D-organoid cultures, correlative light- and electron microscopy, electrophysiology, and single-cell RNA sequencing, this project aims to address the questions i) which molecular mechanisms mediate hormone secretion from EC cells, ii) what are the functional properties of the release process, and iii) how are local circuits organized to signal information to the ENS and brain. The results from this study will allow me to answer the fundamental question whether EC cells form functional synaptic connections, as well as providing a comprehensive overview over the functional and molecular properties of these ‘synapses’.

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The information about "SYNGUT" are provided by the European Opendata Portal: CORDIS opendata.

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