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SynGut SIGNED

Molecular, morphological, and functional requirements for gastrointestinal serotonin release

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SynGut project word cloud

Explore the words cloud of the SynGut project. It provides you a very rough idea of what is the project "SynGut" about.

multiple    date    reminiscent    critical    context    lie    contacts    diabetes    implicated    accordingly    difficult    regulating    pain    diseases    synapse    enteroendocrine    inflammatory    obesity    bowel    molecular    group    form    secretion    ec    neuronal    multidisciplinary    question    electrophysiology    impairments    strikingly    pathogenesis    function    signalling    intestinal    rna    morphological    visceral    electron    plays    spatial    cells    combining    light    connections    brain    synapses    single    hypothesis    gastro    nervous    3d    gi    me    heart    intriguing    eecs    poorly    questions    treating    cultures    cellular    circuits    signal    ens    enteric    tract    local    synaptic    communication    fundamental    microscopy    serotonin    sequencing    secreting    density    answer    notably    functional    overview    release    correlative    disorders    hormone    organoid    chemoreceptors    mechano    enterochromaffin    mechanism    mechanisms    cell    gut    mediate   

Project "SynGut" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 207˙312 €
 EC max contribution 207˙312 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-03-01   to  2022-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 207˙312.00

Map

 Project objective

Communication between the gastro-intestinal (GI) tract, the enteric nervous system (ENS), and the brain plays an important role in regulating our behaviour, and accordingly, impairments in this communication have been implicated in the pathogenesis of multiple disorders including obesity, diabetes, visceral pain, and inflammatory bowel diseases. A better understanding of the molecular and cellular mechanisms of gut-to-brain signalling will be critical for treating these disorders. An important group of cells in this context are enteroendocrine cells (EECs), and most notably enterochromaffin (EC) cells, which function as mechano- and chemoreceptors and signal by secreting serotonin, however the release process is poorly understood. Strikingly, these cells show molecular and morphological features that are highly reminiscent of neuronal synapses in the brain, raising the intriguing hypothesis that they may form synapse-like contacts that lie at the heart of their communication mechanism. To date, however, this hypothesis has been difficult to test due to the low spatial density of EC cells along the GI tract. Using a multidisciplinary approach combining intestinal 3D-organoid cultures, correlative light- and electron microscopy, electrophysiology, and single-cell RNA sequencing, this project aims to address the questions i) which molecular mechanisms mediate hormone secretion from EC cells, ii) what are the functional properties of the release process, and iii) how are local circuits organized to signal information to the ENS and brain. The results from this study will allow me to answer the fundamental question whether EC cells form functional synaptic connections, as well as providing a comprehensive overview over the functional and molecular properties of these ‘synapses’.

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The information about "SYNGUT" are provided by the European Opendata Portal: CORDIS opendata.

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