Opendata, web and dolomites

RegRNA SIGNED

Mechanistic principles of regulation by small RNAs

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 RegRNA project word cloud

Explore the words cloud of the RegRNA project. It provides you a very rough idea of what is the project "RegRNA" about.

principles    gene    2400    srnas    alluded    coli    ways    exposing    mechanism    circuitry    dependent    effect    mature    power    suggest    srna    translation    regulating    transcriptional    direct    underlying    few    cellular    shed    perceived    examples    global    assisting    manipulate    termination    ribosome    intriguing    alternative    ril    cleavage    contexts    pausing    certain    biology    binding    base    seq    rnase    escherichia    light    blocking    exerting    implications    function    advantage    rna    interfering    manipulation    expression    post    versatile    deciphered    synthetic    employs    small    site    technologies    pairing    circuits    pathogenic    map    accumulating    innovative    employed    regulation    rnas    revealing    mainly    preliminary    latter    modes    regulatory    rho    transcriptome    regulated    feasibility    integration    transcription    regulators    basis    detection    elongation    molecular    bacteria    trans    network    pairs    vivo   

Project "RegRNA" data sheet

The following table provides information about the project.

Coordinator
THE HEBREW UNIVERSITY OF JERUSALEM 

Organization address
address: EDMOND J SAFRA CAMPUS GIVAT RAM
city: JERUSALEM
postcode: 91904
website: www.huji.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 2˙278˙125 €
 EC max contribution 2˙278˙125 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2024-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE HEBREW UNIVERSITY OF JERUSALEM IL (JERUSALEM) coordinator 2˙278˙125.00

Map

 Project objective

Small RNAs (sRNAs) are major regulators of gene expression in bacteria, exerting their regulation in trans by base pairing with target RNAs. Traditionally, sRNAs were considered post-transcriptional regulators, mainly regulating translation by blocking or exposing the ribosome binding site. However, accumulating evidence suggest that sRNAs can exploit the base pairing to manipulate their targets in different ways, assisting or interfering with various molecular processes involving the target RNA. Currently there are a few examples of these alternative regulation modes, but their extent and implications in the cellular circuitry have not been assessed. Here we propose to take advantage of the power of RNA-seq-based technologies to develop innovative approaches to address these challenges transcriptome-wide. These approaches will enable us to map the regulatory mechanism a sRNA employs per target through its effect on a certain molecular process. For feasibility we propose studying three processes: RNA cleavage by RNase E, pre-mature Rho-dependent transcription termination, and transcription elongation pausing. Finding targets regulated by sRNA manipulation of the two latter processes would be especially intriguing, as it would suggest that sRNAs can function as gene-specific transcription regulators (alluded to by our preliminary results). As a basis of our research we will use the network of ~2400 sRNA-target pairs in Escherichia coli, deciphered by RIL-seq (a method we recently developed for global in vivo detection of sRNA targets). Revealing the regulatory mechanism(s) employed per target will shed light on the principles underlying the integration of distinct sRNA regulation modes in specific regulatory circuits and cellular contexts, with direct implications to synthetic biology and pathogenic bacteria. Our study may change the way sRNAs are perceived, from post-transcriptional to versatile regulators that apply different regulation modes to different targets.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "REGRNA" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "REGRNA" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

LO-KMOF (2019)

Vapour-deposited metal-organic frameworks as high-performance gap-filling dielectrics for nanoelectronics

Read More  

PLAT_ACE (2019)

A new platform technology for the on-demand access to large acenes

Read More  

TRUST (2018)

Truth and Semantics

Read More