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RegRNA SIGNED

Mechanistic principles of regulation by small RNAs

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 RegRNA project word cloud

Explore the words cloud of the RegRNA project. It provides you a very rough idea of what is the project "RegRNA" about.

feasibility    integration    global    srna    regulatory    regulation    intriguing    assisting    versatile    principles    ribosome    vivo    direct    perceived    cleavage    preliminary    transcriptional    binding    deciphered    employed    power    function    map    exposing    expression    post    implications    manipulate    light    innovative    bacteria    circuits    shed    escherichia    regulated    2400    examples    alluded    regulating    pathogenic    small    manipulation    accumulating    technologies    alternative    exerting    elongation    biology    pausing    termination    interfering    rnas    suggest    gene    site    detection    rho    revealing    seq    mainly    regulators    circuitry    dependent    translation    transcriptome    cellular    latter    coli    basis    srnas    mechanism    advantage    certain    blocking    molecular    ril    underlying    pairing    pairs    trans    network    effect    contexts    base    rna    rnase    modes    few    mature    synthetic    transcription    employs    ways   

Project "RegRNA" data sheet

The following table provides information about the project.

Coordinator
THE HEBREW UNIVERSITY OF JERUSALEM 

Organization address
address: EDMOND J SAFRA CAMPUS GIVAT RAM
city: JERUSALEM
postcode: 91904
website: www.huji.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 2˙278˙125 €
 EC max contribution 2˙278˙125 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2024-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE HEBREW UNIVERSITY OF JERUSALEM IL (JERUSALEM) coordinator 2˙278˙125.00

Map

 Project objective

Small RNAs (sRNAs) are major regulators of gene expression in bacteria, exerting their regulation in trans by base pairing with target RNAs. Traditionally, sRNAs were considered post-transcriptional regulators, mainly regulating translation by blocking or exposing the ribosome binding site. However, accumulating evidence suggest that sRNAs can exploit the base pairing to manipulate their targets in different ways, assisting or interfering with various molecular processes involving the target RNA. Currently there are a few examples of these alternative regulation modes, but their extent and implications in the cellular circuitry have not been assessed. Here we propose to take advantage of the power of RNA-seq-based technologies to develop innovative approaches to address these challenges transcriptome-wide. These approaches will enable us to map the regulatory mechanism a sRNA employs per target through its effect on a certain molecular process. For feasibility we propose studying three processes: RNA cleavage by RNase E, pre-mature Rho-dependent transcription termination, and transcription elongation pausing. Finding targets regulated by sRNA manipulation of the two latter processes would be especially intriguing, as it would suggest that sRNAs can function as gene-specific transcription regulators (alluded to by our preliminary results). As a basis of our research we will use the network of ~2400 sRNA-target pairs in Escherichia coli, deciphered by RIL-seq (a method we recently developed for global in vivo detection of sRNA targets). Revealing the regulatory mechanism(s) employed per target will shed light on the principles underlying the integration of distinct sRNA regulation modes in specific regulatory circuits and cellular contexts, with direct implications to synthetic biology and pathogenic bacteria. Our study may change the way sRNAs are perceived, from post-transcriptional to versatile regulators that apply different regulation modes to different targets.

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The information about "REGRNA" are provided by the European Opendata Portal: CORDIS opendata.

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