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Linking Functional impact and Microstructural properties of fiber tract demyelination and remyelination in a rodent model of multiple sclerosis

Total Cost €


EC-Contrib. €






 LinkFM project word cloud

Explore the words cloud of the LinkFM project. It provides you a very rough idea of what is the project "LinkFM" about.

propagation    repair    ing    monitoring    nervous    bridge    re    rat    inflammatory    diameter    parallel    axonal    lines    myelinisation    create    membrane    scales    amount    sclerosis    prospectively    degeneration    axons    calcium    perform    connected    demyelination    diffusion    central    leveraging    remyelination    neurodegenerative    optimize    sequences    informing    recording    content    myelin    models    impairing    delays    multimodal    functional    trans    circuits    optimized    trigger    de    lesioned    treatment    drcmr    quantitative    personalized    yield    damage    myelination    combine    mr    white    expertise    axon    building    trace    biophysical    disease    wrapped    integrates    inter    cell    biomarkers    integration    diffuse    network    poorly    ms    mapping    blocks    disentangle    neuroinflammation    connectivity    patients    simultaneous    dynamics    exact    multiple    optogenetics    reparatory    microstructural    framework    sensitive    temporal    cortical    neuronal    relationship    resting    tracts    destroys    leads    mri    signal    intracellular    tract    cellular    voltage    dysfunction    primary    brain    sheaths    model   

Project "LinkFM" data sheet

The following table provides information about the project.


Organization address
postcode: 3400

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 219˙312 €
 EC max contribution 219˙312 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    REGION HOVEDSTADEN DK (HILLEROD) coordinator 219˙312.00


 Project objective

Multiple sclerosis (MS) is a diffuse inflammatory and neurodegenerative disease of the central nervous system. Neuroinflammation destroys the myelin sheaths wrapped around the axons and may lead to axon degeneration. Repair processes trigger re-myelinisation. Myelin loss delays or blocks signal propagation along axons in white matter tracts, impairing neuronal integration within the affected brain network. The exact relationship between the amount of axonal de- and re-myelination and the resulting network dysfunction is still poorly understood. Using a rat MS model, I will bridge the scales from the cellular to the network level, to disentangle how myelin loss and axonal degeneration leads to network dysfunction. My approach integrates three lines of research: (i) I will prospectively perform diffusion MRI and quantitative MRI to assess the temporal dynamics of microstructural changes in axon diameter and myelin content in the lesioned white matter tract. Leveraging state-of-art expertise at DRCMR, I will optimize MR sequences and biophysical models to create an optimized axon diameter and myelin mapping framework. (ii) In parallel, I will perform resting-state and task-based functional MRI to trace the resulting changes in functional connectivity at the network level. (iii) Building on my expertise, I will combine functional MRI with optogenetics and simultaneous intracellular calcium (and trans-membrane voltage) recording to characterize in detail the functional impact of axonal damage in the lesioned white matter tract on well-defined cell circuits in the inter-connected cortical areas. This unique multimodal approach will yield novel MRI-based biomarkers that are sensitive and specific to primary demyelination and axonal degeneration on the one hand and reparatory processes such as remyelination on the other hand. These biomarkers will have great potential for monitoring disease activity, informing personalized treatment in patients with MS.

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The information about "LINKFM" are provided by the European Opendata Portal: CORDIS opendata.

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