Opendata, web and dolomites

LinkFM SIGNED

Linking Functional impact and Microstructural properties of fiber tract demyelination and remyelination in a rodent model of multiple sclerosis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 LinkFM project word cloud

Explore the words cloud of the LinkFM project. It provides you a very rough idea of what is the project "LinkFM" about.

diameter    resting    myelin    integration    cortical    network    propagation    leveraging    mri    neuronal    lesioned    biomarkers    sensitive    temporal    multimodal    inter    mr    exact    treatment    drcmr    amount    dysfunction    trace    multiple    bridge    perform    signal    neurodegenerative    patients    impairing    demyelination    framework    content    tract    connectivity    relationship    parallel    optimize    destroys    primary    axonal    de    disentangle    cell    monitoring    rat    cellular    optogenetics    simultaneous    sheaths    biophysical    personalized    tracts    building    trigger    diffuse    model    myelinisation    degeneration    nervous    ing    disease    delays    microstructural    central    sclerosis    diffusion    integrates    blocks    axon    recording    remyelination    neuroinflammation    expertise    mapping    white    sequences    brain    myelination    create    damage    functional    combine    re    connected    poorly    leads    trans    yield    informing    optimized    axons    inflammatory    scales    models    intracellular    calcium    voltage    wrapped    ms    quantitative    prospectively    repair    reparatory    circuits    dynamics    lines    membrane   

Project "LinkFM" data sheet

The following table provides information about the project.

Coordinator
REGION HOVEDSTADEN 

Organization address
address: KONGENS VAENGE 2
city: HILLEROD
postcode: 3400
website: www.regionh.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 219˙312 €
 EC max contribution 219˙312 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    REGION HOVEDSTADEN DK (HILLEROD) coordinator 219˙312.00

Map

 Project objective

Multiple sclerosis (MS) is a diffuse inflammatory and neurodegenerative disease of the central nervous system. Neuroinflammation destroys the myelin sheaths wrapped around the axons and may lead to axon degeneration. Repair processes trigger re-myelinisation. Myelin loss delays or blocks signal propagation along axons in white matter tracts, impairing neuronal integration within the affected brain network. The exact relationship between the amount of axonal de- and re-myelination and the resulting network dysfunction is still poorly understood. Using a rat MS model, I will bridge the scales from the cellular to the network level, to disentangle how myelin loss and axonal degeneration leads to network dysfunction. My approach integrates three lines of research: (i) I will prospectively perform diffusion MRI and quantitative MRI to assess the temporal dynamics of microstructural changes in axon diameter and myelin content in the lesioned white matter tract. Leveraging state-of-art expertise at DRCMR, I will optimize MR sequences and biophysical models to create an optimized axon diameter and myelin mapping framework. (ii) In parallel, I will perform resting-state and task-based functional MRI to trace the resulting changes in functional connectivity at the network level. (iii) Building on my expertise, I will combine functional MRI with optogenetics and simultaneous intracellular calcium (and trans-membrane voltage) recording to characterize in detail the functional impact of axonal damage in the lesioned white matter tract on well-defined cell circuits in the inter-connected cortical areas. This unique multimodal approach will yield novel MRI-based biomarkers that are sensitive and specific to primary demyelination and axonal degeneration on the one hand and reparatory processes such as remyelination on the other hand. These biomarkers will have great potential for monitoring disease activity, informing personalized treatment in patients with MS.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "LINKFM" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "LINKFM" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

ReSOLeS (2019)

New Reconfigurable Spectrum Optical Fibre Laser Sources

Read More  

ICARUS (2020)

Information Content of locAlisation: fRom classical to qUantum Systems

Read More  

EVOMET (2019)

The rise and fall of metastatic clones under immune attack

Read More