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Linking Functional impact and Microstructural properties of fiber tract demyelination and remyelination in a rodent model of multiple sclerosis

Total Cost €


EC-Contrib. €






 LinkFM project word cloud

Explore the words cloud of the LinkFM project. It provides you a very rough idea of what is the project "LinkFM" about.

rat    treatment    remyelination    central    prospectively    dysfunction    multimodal    combine    calcium    personalized    myelin    network    recording    lines    functional    sensitive    neurodegenerative    scales    trigger    neuronal    damage    biomarkers    perform    optimized    integrates    multiple    delays    membrane    sheaths    inter    disentangle    biophysical    axonal    impairing    connectivity    blocks    sequences    intracellular    re    signal    voltage    amount    degeneration    destroys    exact    nervous    models    mapping    ing    trans    relationship    tract    building    cortical    temporal    wrapped    tracts    primary    content    demyelination    lesioned    create    diffusion    diffuse    circuits    cellular    myelination    disease    resting    brain    quantitative    monitoring    poorly    ms    inflammatory    framework    informing    axons    drcmr    trace    myelinisation    expertise    mr    de    sclerosis    patients    neuroinflammation    model    leads    dynamics    cell    propagation    integration    diameter    parallel    bridge    connected    reparatory    optimize    white    simultaneous    mri    leveraging    optogenetics    yield    microstructural    repair    axon   

Project "LinkFM" data sheet

The following table provides information about the project.


Organization address
postcode: 3400

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 219˙312 €
 EC max contribution 219˙312 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    REGION HOVEDSTADEN DK (HILLEROD) coordinator 219˙312.00


 Project objective

Multiple sclerosis (MS) is a diffuse inflammatory and neurodegenerative disease of the central nervous system. Neuroinflammation destroys the myelin sheaths wrapped around the axons and may lead to axon degeneration. Repair processes trigger re-myelinisation. Myelin loss delays or blocks signal propagation along axons in white matter tracts, impairing neuronal integration within the affected brain network. The exact relationship between the amount of axonal de- and re-myelination and the resulting network dysfunction is still poorly understood. Using a rat MS model, I will bridge the scales from the cellular to the network level, to disentangle how myelin loss and axonal degeneration leads to network dysfunction. My approach integrates three lines of research: (i) I will prospectively perform diffusion MRI and quantitative MRI to assess the temporal dynamics of microstructural changes in axon diameter and myelin content in the lesioned white matter tract. Leveraging state-of-art expertise at DRCMR, I will optimize MR sequences and biophysical models to create an optimized axon diameter and myelin mapping framework. (ii) In parallel, I will perform resting-state and task-based functional MRI to trace the resulting changes in functional connectivity at the network level. (iii) Building on my expertise, I will combine functional MRI with optogenetics and simultaneous intracellular calcium (and trans-membrane voltage) recording to characterize in detail the functional impact of axonal damage in the lesioned white matter tract on well-defined cell circuits in the inter-connected cortical areas. This unique multimodal approach will yield novel MRI-based biomarkers that are sensitive and specific to primary demyelination and axonal degeneration on the one hand and reparatory processes such as remyelination on the other hand. These biomarkers will have great potential for monitoring disease activity, informing personalized treatment in patients with MS.

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The information about "LINKFM" are provided by the European Opendata Portal: CORDIS opendata.

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