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Linking Functional impact and Microstructural properties of fiber tract demyelination and remyelination in a rodent model of multiple sclerosis

Total Cost €


EC-Contrib. €






 LinkFM project word cloud

Explore the words cloud of the LinkFM project. It provides you a very rough idea of what is the project "LinkFM" about.

leveraging    scales    neuronal    circuits    drcmr    relationship    mapping    degeneration    sensitive    inflammatory    blocks    myelination    trace    connected    cortical    axons    dysfunction    lines    propagation    monitoring    patients    rat    microstructural    integration    destroys    tracts    reparatory    central    calcium    poorly    signal    demyelination    temporal    content    resting    membrane    biomarkers    remyelination    biophysical    repair    neuroinflammation    axon    combine    exact    ms    parallel    building    perform    brain    lesioned    informing    disease    model    damage    multimodal    mr    optimized    connectivity    diffuse    re    delays    trans    integrates    amount    expertise    cellular    framework    voltage    optimize    de    optogenetics    models    mri    network    primary    axonal    sequences    yield    inter    white    intracellular    quantitative    neurodegenerative    sclerosis    prospectively    myelin    tract    diffusion    personalized    trigger    leads    treatment    impairing    wrapped    dynamics    cell    ing    recording    bridge    nervous    myelinisation    create    simultaneous    diameter    multiple    functional    disentangle    sheaths   

Project "LinkFM" data sheet

The following table provides information about the project.


Organization address
postcode: 3400

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 219˙312 €
 EC max contribution 219˙312 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2019
 Duration (year-month-day) from 2019-05-01   to  2021-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    REGION HOVEDSTADEN DK (HILLEROD) coordinator 219˙312.00


 Project objective

Multiple sclerosis (MS) is a diffuse inflammatory and neurodegenerative disease of the central nervous system. Neuroinflammation destroys the myelin sheaths wrapped around the axons and may lead to axon degeneration. Repair processes trigger re-myelinisation. Myelin loss delays or blocks signal propagation along axons in white matter tracts, impairing neuronal integration within the affected brain network. The exact relationship between the amount of axonal de- and re-myelination and the resulting network dysfunction is still poorly understood. Using a rat MS model, I will bridge the scales from the cellular to the network level, to disentangle how myelin loss and axonal degeneration leads to network dysfunction. My approach integrates three lines of research: (i) I will prospectively perform diffusion MRI and quantitative MRI to assess the temporal dynamics of microstructural changes in axon diameter and myelin content in the lesioned white matter tract. Leveraging state-of-art expertise at DRCMR, I will optimize MR sequences and biophysical models to create an optimized axon diameter and myelin mapping framework. (ii) In parallel, I will perform resting-state and task-based functional MRI to trace the resulting changes in functional connectivity at the network level. (iii) Building on my expertise, I will combine functional MRI with optogenetics and simultaneous intracellular calcium (and trans-membrane voltage) recording to characterize in detail the functional impact of axonal damage in the lesioned white matter tract on well-defined cell circuits in the inter-connected cortical areas. This unique multimodal approach will yield novel MRI-based biomarkers that are sensitive and specific to primary demyelination and axonal degeneration on the one hand and reparatory processes such as remyelination on the other hand. These biomarkers will have great potential for monitoring disease activity, informing personalized treatment in patients with MS.

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The information about "LINKFM" are provided by the European Opendata Portal: CORDIS opendata.

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