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GLYCO-WAY SIGNED

Glycomics of Winery Antimicrobial Yeast

Total Cost €

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EC-Contrib. €

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Partnership

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 GLYCO-WAY project word cloud

Explore the words cloud of the GLYCO-WAY project. It provides you a very rough idea of what is the project "GLYCO-WAY" about.

barrier    unravel    modulating    structure    significantly    hypothesis    expert    internationally    glucan    microbiota    food    amr    microbial    antibiotic    implementing    technological    uc    serious    molecules    mostly    infections    strategy    analytical    challenged    nature    mitigating    spread    line    center    action    anti    insights    toolsets    spain    burden    subsequently    underlying    primitive    strains    combination    reference    mannan    effectiveness    deaths    25k    usa    prebiotics    hinders    yeast    rudimentary    positive    transferred    independence    lacking    madrid    heterogeneous    characterization    structures    feed    healthcare    barile    employ    cerevisiae    industry    fine    generates    strengthen    mechanism    annually    supplements    cutting    gained    identification    polysaccharides    saccharomyces    resistance    edge    productive    biological    intestinal    mainly    showed    lab    csic    isolated    breakthroughs    billion    walls    wine    gut    professional    glycomics    davis    delays    science    emergence    reveal    cell    mechanistic   

Project "GLYCO-WAY" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 263˙732 €
 EC max contribution 263˙732 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-GF
 Starting year 2020
 Duration (year-month-day) from 2020-04-29   to  2023-04-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 263˙732.00
2    THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US (OAKLAND CA) partner 0.00

Map

 Project objective

The recent emergence and spread of anti-microbial resistance (AMR) generates serious concerns. AMR related infections result in 25K deaths and €1.5 billion healthcare costs in the EU annually. A promising strategy involves strengthening the intestinal barrier and modulating gut microbiota using prebiotics. Cell walls polysaccharides, mainly from S. cerevisiae, showed great potential for mitigating antibiotic burden. At present however, our understanding of the mechanism of action underlying these biological effects is significantly lacking, mostly due a rudimentary characterization which hinders identification of key molecules and delays the production of effective feed supplements. This primitive characterization is due to the heterogeneous nature of polysaccharides, which have challenged researchers for years. Recent technological breakthroughs now provide analytical toolsets that enable a more comprehensive understanding of the fine structure of large polysaccharides. Based on the hypothesis that other yeast strains will have the same positive effects than S. cerevisiae, this project will employ cutting edge Glycomics approaches to unravel mannan and glucan structures from the most widely used non-saccharomyces yeast strains in the wine industry, and subsequently evaluate their effectiveness, isolated and in combination, to reveal key mechanistic insights. The project will be carried out in The Barile Lab at the UC-Davis (USA), an internationally recognized center with experience in Glycomics applied to Food Science, and in the CSIC (Spain), one of the most productive research institution in EU. The knowledge gained by the applicant in Glycomics for Food Science will be transferred to the EU by implementing a European Reference Center in this field at CSIC (Madrid, Spain). The objectives proposed, will enable the applicant to become an expert in glycomics and strengthen his professional independence. The proposed research is in line with the H2020 objectives.

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The information about "GLYCO-WAY" are provided by the European Opendata Portal: CORDIS opendata.

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