Opendata, web and dolomites

EVER SIGNED

Evolution of VEnom Regulation

Total Cost €

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EC-Contrib. €

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Partnership

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 EVER project word cloud

Explore the words cloud of the EVER project. It provides you a very rough idea of what is the project "EVER" about.

analysing    functionally    kingdom    innovative    de    cell    emerge    shed    q1    pattern    structures    hierarchical    developmental    gland    weapon    regulatory    transcriptomic    evolutionary    training    types    possess    evolution    overlap    pioneer    career    develop    independently    traits    patterns    novelty    transcriptomes    independent    predators    bioinformatics    intensive    organs    emergence    lineages    mainly    q3    lineage    trait    devo    restarting    snail    breaking    light    underlying    potent    neogastropoda    hosting    groups    structurally    unknown    universit    expression    prey    anatomical    animal    omics    ensured    myself    phyla    gene    adaptive    animals    mechanisms    questions    tissues    specialized    venomous    venom    convergence    ground    explosion    q2    biochemical    convergent    lausanne    subdue    eacute    integration    tissue    original    revolution    answer    evo    transcriptome    leader    area    homologous    remarkable    molecular    cone    biodiscovery    establishing    repeatedly    experts   

Project "EVER" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE LAUSANNE 

Organization address
address: Quartier Unil-Centre Bâtiment Unicentre
city: LAUSANNE
postcode: 1015
website: www.unil.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 286˙724 €
 EC max contribution 286˙724 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2022-08-06

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LAUSANNE CH (LAUSANNE) coordinator 286˙724.00

Map

 Project objective

Animal venom is a remarkable example of convergent evolutionary novelty - it has independently evolved across all phyla of the animal kingdom to subdue prey and predators. To produce and deliver this potent biochemical weapon, venomous animals possess specialized anatomical structures which emerge from different developmental tissues in the various lineages. How animals have repeatedly evolved this key adaptive trait is unknown. The recent omics revolution has generated an explosion of venom-gland transcriptomes mainly for biodiscovery. However, the mechanisms underlying the emergence and regulatory evolution of venom have not been investigated. In this ambitious and ground-breaking project, I will use a hierarchical approach and large-scale comparative transcriptomic analyses to shed light on the following open questions: Q1) To what extent is the independent evolution of novel adaptive traits associated with convergence in transcriptome evolution? Q2) Which molecular processes contribute to the evolution of these innovative traits? Q3) To what extent does the expression pattern of new specialized cell types overlap the original tissue from which they develop? I will answer Q1 by comparing non-homologous venom-gland transcriptomes across the major lineages of the animal kingdom. I will answer Q2 by focusing on one lineage (Neogastropoda) and comparing the venom-gland with homologous, non-venomous organs. Finally, I will answer Q3 by analysing gene expression patterns between structurally and functionally different cell types within the venom-gland. The success of this project is ensured by the integration in top hosting bioinformatics groups at the Université de Lausanne and collaboration with leading experts in cone snail evolution. This project will provide intensive training which is crucial for restarting my research career and establishing myself as a pioneer and leader in a new research area, venom evo-devo.

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The information about "EVER" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2022-10-01 11:46:30) correctly updated