Opendata, web and dolomites

EVER SIGNED

Evolution of VEnom Regulation

Total Cost €

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EC-Contrib. €

0

Partnership

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 EVER project word cloud

Explore the words cloud of the EVER project. It provides you a very rough idea of what is the project "EVER" about.

overlap    mechanisms    types    transcriptome    de    independent    q1    shed    adaptive    questions    underlying    gland    homologous    prey    q3    neogastropoda    cone    lineage    answer    convergent    regulatory    establishing    innovative    bioinformatics    cell    developmental    phyla    convergence    snail    omics    restarting    structurally    training    transcriptomes    revolution    tissue    light    trait    lineages    eacute    anatomical    emergence    possess    expression    biochemical    intensive    venomous    specialized    leader    animal    biodiscovery    q2    integration    predators    explosion    tissues    unknown    kingdom    groups    area    mainly    animals    gene    career    ensured    potent    weapon    devo    ground    independently    lausanne    hosting    analysing    pioneer    experts    evolution    functionally    myself    venom    breaking    hierarchical    evolutionary    patterns    evo    novelty    universit    develop    pattern    emerge    subdue    structures    remarkable    original    traits    molecular    transcriptomic    repeatedly    organs   

Project "EVER" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE LAUSANNE 

Organization address
address: Quartier Unil-Centre Bâtiment Unicentre
city: LAUSANNE
postcode: 1015
website: www.unil.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 286˙724 €
 EC max contribution 286˙724 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2019
 Duration (year-month-day) from 2019-07-01   to  2022-08-06

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LAUSANNE CH (LAUSANNE) coordinator 286˙724.00

Map

 Project objective

Animal venom is a remarkable example of convergent evolutionary novelty - it has independently evolved across all phyla of the animal kingdom to subdue prey and predators. To produce and deliver this potent biochemical weapon, venomous animals possess specialized anatomical structures which emerge from different developmental tissues in the various lineages. How animals have repeatedly evolved this key adaptive trait is unknown. The recent omics revolution has generated an explosion of venom-gland transcriptomes mainly for biodiscovery. However, the mechanisms underlying the emergence and regulatory evolution of venom have not been investigated. In this ambitious and ground-breaking project, I will use a hierarchical approach and large-scale comparative transcriptomic analyses to shed light on the following open questions: Q1) To what extent is the independent evolution of novel adaptive traits associated with convergence in transcriptome evolution? Q2) Which molecular processes contribute to the evolution of these innovative traits? Q3) To what extent does the expression pattern of new specialized cell types overlap the original tissue from which they develop? I will answer Q1 by comparing non-homologous venom-gland transcriptomes across the major lineages of the animal kingdom. I will answer Q2 by focusing on one lineage (Neogastropoda) and comparing the venom-gland with homologous, non-venomous organs. Finally, I will answer Q3 by analysing gene expression patterns between structurally and functionally different cell types within the venom-gland. The success of this project is ensured by the integration in top hosting bioinformatics groups at the Université de Lausanne and collaboration with leading experts in cone snail evolution. This project will provide intensive training which is crucial for restarting my research career and establishing myself as a pioneer and leader in a new research area, venom evo-devo.

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The information about "EVER" are provided by the European Opendata Portal: CORDIS opendata.

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