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EMPAtHy SIGNED

Endothelial Cell Molecular and Metabolic Heterogeneity in Pulmonary Arterial Hypertension

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 EMPAtHy project word cloud

Explore the words cloud of the EMPAtHy project. It provides you a very rough idea of what is the project "EMPAtHy" about.

stimuli    poor    pressure    background    never    arterial    profiles    goals    output    ec    pulmonary    time    forces    insights    environment    basis    arteries    survival    disease    metabolically    vivo    animal    isolated    rewiring    microenvironments    thesis    patients    ph    lay    expertise    host    frontline    intrapulmonary    successful    me    heterogeneity    expression    scrna    cells    model    cell    incurable    validated    therapy    disciplinary    overlooked    phenotypic    devastating    career    heterogeneous    promises    sequencing    international    endothelial    competitive    subpopulations    combining    lung    gene    clinically    phd    paradigm    scientific    foundation    single    phenotypically    pathophysiology    ameliorative    pah    curative    though    metabolic    academia    promotes    yield    remodeling    innovative    replacement    rna    achievement    vascular    intense    exposed    dramatic    driving    ecs    metabolism    lab    unbiased    experimental    hemodynamic    seq    freshly    science    1st    diverse    small    exception    proof    shown    hypertension   

Project "EMPAtHy" data sheet

The following table provides information about the project.

Coordinator
VIB VZW 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 166˙320 €
 EC max contribution 166˙320 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB VZW BE (ZWIJNAARDE - GENT) coordinator 166˙320.00

Map

 Project objective

BACKGROUND: Pulmonary arterial hypertension (PAH) is a devastating disease, characterized by a dramatic increase in pulmonary arterial pressure and an intense remodeling of small intrapulmonary arteries. With the exception of the lung replacement therapy, PAH remains an incurable disease with poor survival. Recent studies have shown that in PAH, rewiring of the metabolism of the lung endothelial cells (ECs) promotes vascular remodeling. However, these studies overlooked that lung ECs are exposed to diverse microenvironments in vivo (various hemodynamic forces and stimuli), which might result in their phenotypic and metabolic heterogeneity, though this has never been investigated. OBJECTIVES & EXPERIMENTAL APPROACH: In order to characterize, for the 1st time, the lung EC heterogeneity in PAH, identify EC subsets, and determine in an unbiased way the metabolic gene expression profiles of these EC subsets, I will use single-cell RNA-sequencing (scRNA-seq) on freshly isolated lung ECs from PAH patients and from an animal model of PH. As proof-of-concept, I will evaluate the effects of a new metabolic therapy on these EC subsets, in vivo, in comparison to a clinically-used, ameliorative but not curative, PAH therapy. This approach, already validated in the host lab, promises to lay the foundation of a new paradigm in PAH where lung ECs are phenotypically and metabolically heterogeneous. It will yield novel insights into PAH pathophysiology, identify specific EC subpopulations driving the vascular remodeling process as well as new potential metabolic targets. CAREER DEVELOPMENT: Combining my expertise on PAH (PhD thesis) together with state-of-the-art frontline technology (scRNA-seq) and innovative science (EC metabolism) (within the host lab) in a multi-disciplinary project and international research environment will ensure successful achievement of the project goals, enhance my scientific output and offer me a highly competitive basis for my future career in academia.

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The information about "EMPATHY" are provided by the European Opendata Portal: CORDIS opendata.

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