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Programmable ARTificial immune systems to fight cancer

Total Cost €


EC-Contrib. €






 ARTimmune project word cloud

Explore the words cloud of the ARTimmune project. It provides you a very rough idea of what is the project "ARTimmune" about.

character    notwithstanding    fundamental    immunomodulators    immunotherapies    tolerable    immunomodulating    infiltration    toxic    destruction    decorated    systemic    scaffolds    sponge    revolutionize    powerhouses    innovative    hypothesize    moving    architecture    vaccinated    dose    centre    single    immune    tools    follow    programmable    accomplished    tuning    entered    cancer    revolutionary    instruct    synthetic    chemical    treatment    patients    porosity    intelligent    pressing    act    direct    powerful    stage    lymph    injected    niches    node    polymeric    local    vicinity    cytotoxic    vivo    immunotherapy    generate    maximal    structures    roadblocks    span    fine    injectable    overcome    immunosuppression    artimmune    blueprint    toxicity    tumour    advantage    obstacles    function    locally    cells    extend    radically    communication    ln    successful    bursts    programming    modality    cell    proteolytic    clusters    mixed    life    branched    molecules    immunological    illustrate    activation    transcriptomics    mimic   

Project "ARTimmune" data sheet

The following table provides information about the project.


Organization address
postcode: 6525 EZ

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2024-10-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Immunotherapy has entered centre stage as a novel treatment modality for cancer. Notwithstanding this major step forward, toxicity and immunosuppression remain major obstacles, and illustrate the pressing need for more powerful and specific immunotherapies against cancer. To overcome these roadblocks, in ARTimmune, I propose to follow a radically different approach by developing local rather than systemic immunotherapies. Taking advantage of the architecture of a lymph node (LN), I aim to design fully synthetic immune niches to locally instruct immune cell function. I hypothesize that programmable synthetic immune niches, when injected next to a tumour, will act as local powerhouses to generate bursts of cytotoxic T cells for tumour destruction, without toxic side effects. Single cell transcriptomics on LN, obtained from patients that are vaccinated against cancer, will provide unique insight in communication within immune cell clusters and provide a blueprint for the intelligent design of synthetic immune niches. Chemical tools will be used to build branched polymeric structures decorated with immunomodulating molecules to mimic LN architecture. These will be injected, mixed with sponge-like scaffolds to provide porosity needed for immune cell infiltration. Programming of immune cell function will be accomplished by in vivo targeting- and proteolytic activation- of immunomodulators for fine-tuning, and to extend the life span of these local powerhouses. The innovative character of ARTimmune comes from: 1) novel fundamental immunological insight in complex communication within LN cell clusters, 2) a revolutionary new approach in immunotherapy, by the development of 3) injectable- and 4) programmable- synthetic immune niches by state-of-the-art chemical technology. When successful, it will revolutionize cancer immunotherapy, moving from maximal tolerable dose systemic treatment with significant toxicity to local low dose treatment in the direct vicinity of a tumour

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The information about "ARTIMMUNE" are provided by the European Opendata Portal: CORDIS opendata.

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