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Programmable ARTificial immune systems to fight cancer

Total Cost €


EC-Contrib. €






 ARTimmune project word cloud

Explore the words cloud of the ARTimmune project. It provides you a very rough idea of what is the project "ARTimmune" about.

cytotoxic    revolutionary    entered    notwithstanding    immunological    clusters    stage    roadblocks    immune    sponge    advantage    scaffolds    programmable    extend    porosity    vaccinated    single    powerhouses    bursts    systemic    follow    programming    communication    niches    cancer    polymeric    branched    locally    injected    generate    direct    immunotherapies    character    vicinity    accomplished    blueprint    instruct    tumour    mixed    function    patients    injectable    fundamental    obstacles    immunomodulators    chemical    proteolytic    activation    innovative    span    decorated    destruction    dose    immunotherapy    immunosuppression    radically    mimic    revolutionize    node    tolerable    fine    local    synthetic    intelligent    maximal    infiltration    act    powerful    hypothesize    cell    centre    illustrate    lymph    artimmune    molecules    vivo    treatment    tools    overcome    structures    successful    moving    immunomodulating    cells    toxicity    modality    transcriptomics    pressing    ln    life    architecture    toxic    tuning   

Project "ARTimmune" data sheet

The following table provides information about the project.


Organization address
postcode: 6525 EZ

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 2˙500˙000 €
 EC max contribution 2˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-ADG
 Funding Scheme ERC-ADG
 Starting year 2019
 Duration (year-month-day) from 2019-11-01   to  2024-10-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Immunotherapy has entered centre stage as a novel treatment modality for cancer. Notwithstanding this major step forward, toxicity and immunosuppression remain major obstacles, and illustrate the pressing need for more powerful and specific immunotherapies against cancer. To overcome these roadblocks, in ARTimmune, I propose to follow a radically different approach by developing local rather than systemic immunotherapies. Taking advantage of the architecture of a lymph node (LN), I aim to design fully synthetic immune niches to locally instruct immune cell function. I hypothesize that programmable synthetic immune niches, when injected next to a tumour, will act as local powerhouses to generate bursts of cytotoxic T cells for tumour destruction, without toxic side effects. Single cell transcriptomics on LN, obtained from patients that are vaccinated against cancer, will provide unique insight in communication within immune cell clusters and provide a blueprint for the intelligent design of synthetic immune niches. Chemical tools will be used to build branched polymeric structures decorated with immunomodulating molecules to mimic LN architecture. These will be injected, mixed with sponge-like scaffolds to provide porosity needed for immune cell infiltration. Programming of immune cell function will be accomplished by in vivo targeting- and proteolytic activation- of immunomodulators for fine-tuning, and to extend the life span of these local powerhouses. The innovative character of ARTimmune comes from: 1) novel fundamental immunological insight in complex communication within LN cell clusters, 2) a revolutionary new approach in immunotherapy, by the development of 3) injectable- and 4) programmable- synthetic immune niches by state-of-the-art chemical technology. When successful, it will revolutionize cancer immunotherapy, moving from maximal tolerable dose systemic treatment with significant toxicity to local low dose treatment in the direct vicinity of a tumour

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The information about "ARTIMMUNE" are provided by the European Opendata Portal: CORDIS opendata.

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